Cognitive-behavioral longitudinal assessment in ALS

the Italian Edinburgh Cognitive and Behavioral ALS screen (ECAS)

Barbara Poletti, Federica Solca, Laura Carelli, Andrea Faini, Fabiana Madotto, Annalisa Lafronza, Alessia Monti, Stefano Zago, Andrea Ciammola, Antonia Ratti, Nicola Ticozzi, Sharon Abrahams, Vincenzo Silani

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: The study presents data on the longitudinal administration of the Italian Edinburgh Cognitive and Behavioral ALS Screen (ECAS). We investigated cognitive-behavioral performance in a group of ALS patients over time and the feasibility of repeating the ECAS longitudinally compared with standard neuropsychological tests. Finally, correlations between clinical/genetic and cognitive/behavioral data were considered.

METHODS: One hundred and sixty-eight ALS patients were tested at baseline (T0). Among these, 48 patients performed the ECAS after 6 months (T1), 18 patients performed it at T2 (12 months), and five patients were assessed after 24 months (T3). Participants were also administered two cognitive test (FAB; MoCA) and psychological questionnaires (BDI; STAI/Y). The FBI was carried out with caregivers.

RESULTS: No cognitive deterioration was found across follow-ups. In contrast, although scores did not change between T0 and T1, scores improved significantly for ECAS Total/ALS Non-specific and Memory domains when the ECAS was repeated on three occasions (T0, T1, T2). Apathy/Inertia was the most common behavioral symptom, but no worsening of behavioral scores was detected over time. After 12-24 months, patients were still able to perform the ECAS in total, in contrast to FAB and MoCA, which were only partially administrable.

CONCLUSIONS: The significant improvement of some ECAS scores over time supports the presence of possible practice effects, particularly in the memory domain, highlighting the need to accommodate for these in longitudinal assessments, through healthy controls groups or alternate versions. This work represents the first Italian ECAS follow-up study and confirms ECAS feasibility in patients with increasing physical disability.

Original languageEnglish
Pages (from-to)387-395
Number of pages9
JournalAmyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Volume19
Issue number5-6
DOIs
Publication statusPublished - Aug 2018

Fingerprint

Behavioral Genetics
Apathy
Behavioral Symptoms
Neuropsychological Tests
Caregivers
Psychology
Control Groups
Surveys and Questionnaires
Practice (Psychology)

Cite this

Cognitive-behavioral longitudinal assessment in ALS : the Italian Edinburgh Cognitive and Behavioral ALS screen (ECAS). / Poletti, Barbara; Solca, Federica; Carelli, Laura; Faini, Andrea; Madotto, Fabiana; Lafronza, Annalisa; Monti, Alessia; Zago, Stefano; Ciammola, Andrea; Ratti, Antonia; Ticozzi, Nicola; Abrahams, Sharon; Silani, Vincenzo.

In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Vol. 19, No. 5-6, 08.2018, p. 387-395.

Research output: Contribution to journalArticle

@article{440f5885a0e14da692f9d68cc0833d66,
title = "Cognitive-behavioral longitudinal assessment in ALS: the Italian Edinburgh Cognitive and Behavioral ALS screen (ECAS)",
abstract = "OBJECTIVE: The study presents data on the longitudinal administration of the Italian Edinburgh Cognitive and Behavioral ALS Screen (ECAS). We investigated cognitive-behavioral performance in a group of ALS patients over time and the feasibility of repeating the ECAS longitudinally compared with standard neuropsychological tests. Finally, correlations between clinical/genetic and cognitive/behavioral data were considered.METHODS: One hundred and sixty-eight ALS patients were tested at baseline (T0). Among these, 48 patients performed the ECAS after 6 months (T1), 18 patients performed it at T2 (12 months), and five patients were assessed after 24 months (T3). Participants were also administered two cognitive test (FAB; MoCA) and psychological questionnaires (BDI; STAI/Y). The FBI was carried out with caregivers.RESULTS: No cognitive deterioration was found across follow-ups. In contrast, although scores did not change between T0 and T1, scores improved significantly for ECAS Total/ALS Non-specific and Memory domains when the ECAS was repeated on three occasions (T0, T1, T2). Apathy/Inertia was the most common behavioral symptom, but no worsening of behavioral scores was detected over time. After 12-24 months, patients were still able to perform the ECAS in total, in contrast to FAB and MoCA, which were only partially administrable.CONCLUSIONS: The significant improvement of some ECAS scores over time supports the presence of possible practice effects, particularly in the memory domain, highlighting the need to accommodate for these in longitudinal assessments, through healthy controls groups or alternate versions. This work represents the first Italian ECAS follow-up study and confirms ECAS feasibility in patients with increasing physical disability.",
author = "Barbara Poletti and Federica Solca and Laura Carelli and Andrea Faini and Fabiana Madotto and Annalisa Lafronza and Alessia Monti and Stefano Zago and Andrea Ciammola and Antonia Ratti and Nicola Ticozzi and Sharon Abrahams and Vincenzo Silani",
year = "2018",
month = "8",
doi = "10.1080/21678421.2018.1473443",
language = "English",
volume = "19",
pages = "387--395",
journal = "Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration",
issn = "2167-8421",
publisher = "Informa Healthcare",
number = "5-6",

}

TY - JOUR

T1 - Cognitive-behavioral longitudinal assessment in ALS

T2 - the Italian Edinburgh Cognitive and Behavioral ALS screen (ECAS)

AU - Poletti, Barbara

AU - Solca, Federica

AU - Carelli, Laura

AU - Faini, Andrea

AU - Madotto, Fabiana

AU - Lafronza, Annalisa

AU - Monti, Alessia

AU - Zago, Stefano

AU - Ciammola, Andrea

AU - Ratti, Antonia

AU - Ticozzi, Nicola

AU - Abrahams, Sharon

AU - Silani, Vincenzo

PY - 2018/8

Y1 - 2018/8

N2 - OBJECTIVE: The study presents data on the longitudinal administration of the Italian Edinburgh Cognitive and Behavioral ALS Screen (ECAS). We investigated cognitive-behavioral performance in a group of ALS patients over time and the feasibility of repeating the ECAS longitudinally compared with standard neuropsychological tests. Finally, correlations between clinical/genetic and cognitive/behavioral data were considered.METHODS: One hundred and sixty-eight ALS patients were tested at baseline (T0). Among these, 48 patients performed the ECAS after 6 months (T1), 18 patients performed it at T2 (12 months), and five patients were assessed after 24 months (T3). Participants were also administered two cognitive test (FAB; MoCA) and psychological questionnaires (BDI; STAI/Y). The FBI was carried out with caregivers.RESULTS: No cognitive deterioration was found across follow-ups. In contrast, although scores did not change between T0 and T1, scores improved significantly for ECAS Total/ALS Non-specific and Memory domains when the ECAS was repeated on three occasions (T0, T1, T2). Apathy/Inertia was the most common behavioral symptom, but no worsening of behavioral scores was detected over time. After 12-24 months, patients were still able to perform the ECAS in total, in contrast to FAB and MoCA, which were only partially administrable.CONCLUSIONS: The significant improvement of some ECAS scores over time supports the presence of possible practice effects, particularly in the memory domain, highlighting the need to accommodate for these in longitudinal assessments, through healthy controls groups or alternate versions. This work represents the first Italian ECAS follow-up study and confirms ECAS feasibility in patients with increasing physical disability.

AB - OBJECTIVE: The study presents data on the longitudinal administration of the Italian Edinburgh Cognitive and Behavioral ALS Screen (ECAS). We investigated cognitive-behavioral performance in a group of ALS patients over time and the feasibility of repeating the ECAS longitudinally compared with standard neuropsychological tests. Finally, correlations between clinical/genetic and cognitive/behavioral data were considered.METHODS: One hundred and sixty-eight ALS patients were tested at baseline (T0). Among these, 48 patients performed the ECAS after 6 months (T1), 18 patients performed it at T2 (12 months), and five patients were assessed after 24 months (T3). Participants were also administered two cognitive test (FAB; MoCA) and psychological questionnaires (BDI; STAI/Y). The FBI was carried out with caregivers.RESULTS: No cognitive deterioration was found across follow-ups. In contrast, although scores did not change between T0 and T1, scores improved significantly for ECAS Total/ALS Non-specific and Memory domains when the ECAS was repeated on three occasions (T0, T1, T2). Apathy/Inertia was the most common behavioral symptom, but no worsening of behavioral scores was detected over time. After 12-24 months, patients were still able to perform the ECAS in total, in contrast to FAB and MoCA, which were only partially administrable.CONCLUSIONS: The significant improvement of some ECAS scores over time supports the presence of possible practice effects, particularly in the memory domain, highlighting the need to accommodate for these in longitudinal assessments, through healthy controls groups or alternate versions. This work represents the first Italian ECAS follow-up study and confirms ECAS feasibility in patients with increasing physical disability.

U2 - 10.1080/21678421.2018.1473443

DO - 10.1080/21678421.2018.1473443

M3 - Article

VL - 19

SP - 387

EP - 395

JO - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

JF - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

SN - 2167-8421

IS - 5-6

ER -