Cognitive competence at the onset of West syndrome: Correlation with EEG patterns and visual function

Teresa Randò, Giovanni Baranello, Daniela Ricci, Andrea Guzzetta, Francesca Tinelli, Enrico Biagioni, Giuseppe La Torre, Roberta Epifanio, Sabrina Signorini, Elisa Fazzi, Eugenio Mercuri, Giovanni Cioni, Francesco Guzzetta

Research output: Contribution to journalArticlepeer-review


The aim of this study was to evaluate cognitive development at the onset of West syndrome (WS) with regard to electroencephalogram (EEG) patterns and visual function. Twenty-five patients (14 males, 11 females) at the onset of spasms (T0) in WS and 2 months later (T1) underwent a full clinical evaluation, including neuroimaging, cognitive assessment, video-EEG, and visual function. Mean age of the patients at spasm onset was 5.9 months (SD 2.5; range 2 to 13mo). Cognitive development, assessed with Griffiths Mental Development Scales (GMDS), was generally impaired at T0 and was significantly related to visual function (p0 and T1. In general, there was a specific major impairment in the eye-hand coordination scale of the GMDS which tended to disappear after 2 months in less severe cases. At the onset of spasms, sleep EEG organization seemed to be better related to cognitive abilities than awake hypsarrhythmia. These results support a close link between visual function and cognitive competence in WS and provide additional information to improve the understanding of possible mechanisms underlying cognitive impairment.

Original languageEnglish
Pages (from-to)760-765
Number of pages6
JournalDevelopmental Medicine and Child Neurology
Issue number11
Publication statusPublished - Nov 2005

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neuroscience(all)


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