TY - JOUR
T1 - Cognitive correlates of impulsive aggression in youth with pediatric bipolar disorder and bipolar offspring
AU - Simonetti, Alessio
AU - Kurian, Sherin
AU - Saxena, Johanna
AU - Verrico, Christopher D.
AU - Soares, Jair C.
AU - Sani, Gabriele
AU - Saxena, Kirti
N1 - Funding Information:
This research was supported by the John S. Dunn Foundation. All the funding sources were not directly involved in the study design, data collection, analyses and interpretation of data, the writing of the article, and in the decision to submit the article to this Journal.
Funding Information:
Alessio Simonetti, Christopher D. Verrico and Gabriele Sani have no conflict of interest. Sherin Kurian, Johanna Saxena and Kirti Saxena were supported by the John S. Dunn Foundation. Jair C. Soares has received grants/research support from BMS, Forrest, J&J, Merck, Stanley Medical Research Institute, NIH and has been a speaker for Pfizer and Abbott.
Publisher Copyright:
© 2021
PY - 2021/5/15
Y1 - 2021/5/15
N2 - Background: Youth with bipolar disorder (BD) and offspring of individuals with BD (BD-OFF) are characterized by higher levels of impulsive and overt aggression. The cognitive basis underlying these aggressive behaviors are not clarified in this population. The aim of this study was to investigate the relationship between cognitive alterations and aggressive behavior in youth with BD and BD-OFF. Methods: Forty-two youth with BD, 17 BD-OFF and 57 healthy controls (HCs) were administered the Modified Overt Aggression Scale (MOAS), the Cambridge Neuropsychological Test Automated Battery (CANTAB), the Young Mania Rating Scale (YMRS) and the Children's Depression Rating Scale (CDRS). Multiple linear regression analyses were performed in the three groups separately. In each group, tests scores from the CANTAB were predictors. MOAS subscale scores and MOAS total scores were dependent variables. Results are corrected for age, IQ and mood state. Results: Both youth with BD and BD-OFF showed positive correlations between impairment in executive functions and levels of verbal aggression. In youth with BD, altered processing of either positive and negative stimuli positively correlated with MOAS total scores, whereas in BD-OFF, such relationship was negative. Conclusions: Impulsive aggressive behaviors in youth with BD arise from a combination of altered affective processing and executive dysfunction. The negative relationship between affective processing and aggression in BD-OFF suggested the presence of possible mechanisms of resilience in this population.
AB - Background: Youth with bipolar disorder (BD) and offspring of individuals with BD (BD-OFF) are characterized by higher levels of impulsive and overt aggression. The cognitive basis underlying these aggressive behaviors are not clarified in this population. The aim of this study was to investigate the relationship between cognitive alterations and aggressive behavior in youth with BD and BD-OFF. Methods: Forty-two youth with BD, 17 BD-OFF and 57 healthy controls (HCs) were administered the Modified Overt Aggression Scale (MOAS), the Cambridge Neuropsychological Test Automated Battery (CANTAB), the Young Mania Rating Scale (YMRS) and the Children's Depression Rating Scale (CDRS). Multiple linear regression analyses were performed in the three groups separately. In each group, tests scores from the CANTAB were predictors. MOAS subscale scores and MOAS total scores were dependent variables. Results are corrected for age, IQ and mood state. Results: Both youth with BD and BD-OFF showed positive correlations between impairment in executive functions and levels of verbal aggression. In youth with BD, altered processing of either positive and negative stimuli positively correlated with MOAS total scores, whereas in BD-OFF, such relationship was negative. Conclusions: Impulsive aggressive behaviors in youth with BD arise from a combination of altered affective processing and executive dysfunction. The negative relationship between affective processing and aggression in BD-OFF suggested the presence of possible mechanisms of resilience in this population.
KW - Aggression
KW - Bipolar offspring
KW - Cognition
KW - Pediatric bipolar disorder
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U2 - 10.1016/j.jad.2021.03.044
DO - 10.1016/j.jad.2021.03.044
M3 - Article
C2 - 33838473
AN - SCOPUS:85103980286
VL - 287
SP - 387
EP - 396
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -