Cognitive decline after carotid endarterectomy: Systematic review and meta-analysis

Paola Aceto, Carlo Lai, Franco De Crescenzo, Maria A Crea, Valeria Di Franco, Gaia R Pellicano, Valter Perilli, Silvia Lai, Domenico Papanice, Liliana Sollazzi

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BACKGROUND: Postoperative cognitive decline (pCD) occurs frequently (6 to 30%) after carotid endarterectomy (CEA), although there are no exact estimates and risk factors are still unclear.OBJECTIVE: The objective of this study was to determine pCD incidence and risk factors in CEA patients.DESIGN: We performed a systematic review and meta-analysis of both randomised and nonrandomised trials following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.DATA SOURCES: We searched Cochrane, PubMed/Medline and Embase databases from the date of database inception to 1 December 2018.ELIGIBILITY CRITERIA: We selected longitudinal studies including CEA patients with both pre-operative and postoperative cognitive assessments. Primary outcome was pCD incidence, differentiating delayed neurocognitive recovery (dNCR) and postoperative neurocognitive disorder (pNCD). dNCR and pNCD incidences were expressed as proportions of cases on total CEA sample and pooled as weighted estimates from proportions. Postoperative delirium was excluded from the study design. Secondary outcomes were patient-related (i.e. age, sex, diabetes, hypertension, contralateral stenosis, pre-operative symptoms, dyslipidaemia and statin use) and procedure-related (i.e. hyperperfusion, cross-clamping duration and shunting placement) risk factors for pCD. We estimated odds ratios (ORs) and mean differences through a random effects model by using STATA 13.1 and RevMan 5.3.RESULTS: Our search identified 5311 publications and 60 studies met inclusion criteria reporting a total of 4823 CEA patients. dNCR and pNCD incidence were 20.5% [95% confidence interval (CI), 17.1 to 24.0] and 14.1% (95% CI, 9.5 to 18.6), respectively. pCD risk was higher in patients experiencing hyperperfusion during surgery (OR, 35.68; 95% CI, 16.64 to 76.51; P 
Original languageEnglish
JournalEuropean Journal of Anaesthesiology
Publication statusPublished - Dec 12 2019


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