Cognitive disorders in the elderly. Genetic and epigenetic aspects

C. Vergani, M. Sampietro, L. Caputo, J. Tagliabue, A. Casatta, M. Meregalli, A. Pellegatti, G. Annoni

Research output: Contribution to journalArticle

Abstract

Alzheimer's disease (AD) represents the most prevalent manifestation of the cognitive disorders in the elderly. The dramatic nature and the economic burden of the disease make AD a worl-wide problem. This paper reviews the genetic factors which explain the pathogenesis of AD, i.e., mutations of the genes encoding the amyloid precursor protein (APP), presenilin 1 (PS-1) and 2 (PS-2). Moreover, the polymorphism of the ApoE gene and the mutations of the hemochromatosis gene (HFE) are discussed. HFE mutations may anticipate the clinical manifestation of AD. The epigenetic factors related to AD are also discussed.

Original languageEnglish
Pages (from-to)429-434
Number of pages6
JournalArchives of Gerontology and Geriatrics
Volume33
Issue numberSUPPL.
DOIs
Publication statusPublished - 2001

Keywords

  • Alzheimer's disease
  • ApoE
  • Hemochromatosis
  • HFE gene
  • Iron metabolism

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

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  • Cite this

    Vergani, C., Sampietro, M., Caputo, L., Tagliabue, J., Casatta, A., Meregalli, M., Pellegatti, A., & Annoni, G. (2001). Cognitive disorders in the elderly. Genetic and epigenetic aspects. Archives of Gerontology and Geriatrics, 33(SUPPL.), 429-434. https://doi.org/10.1016/S0167-4943(01)00170-4