Cognitive dysfunctions and Pathological gambling in patients with Parkinson's disease

Gabriella Santangelo, Carmine Vitale, Luigi Trojano, Francesca Verde, Dario Grossi, Paolo Barone

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

The purpose of this study was to investigate the neuropsychological correlates of pathological gambling (PG) in Parkinson's disease (PD). Fifteen patients with PD affected by PG (identified based on DSM-IV criteria; PD+PG) without clinically evident dementia were compared with 15 nondemented patients with PD not affected by PG (PD-PG). Two groups of patients with PD were matched for age, length of education, and gender. Clinical and neuropsychiatric features were assessed; several cognitive domains, mainly related to executive functions, were explored by means of standardized neuropsychological tasks. PD+PG and PD-PG did not differ on clinical and neuropsychiatric aspects. PD+PG patients performed significantly worse than PD-PG patients on cognitive tasks that evaluated visuo-spatial long-term memory and several frontal lobe functions. After Bonferroni correction, differences remained significant on the Frontal Assessment Battery (FAB) (P = 0.001), on phonological fluency task (P = 0.003), and on the Trail Making Test, part B minus part A (P = 0.002). Logistic regression analysis demonstrated that low scores on the FAB were the only independent predictor of PG (odds ratio, 27.9; 95% CI: 2.82-277.95, P = 0.004). The results indicate an association between PG and frontal lobe dysfunctions in nondemented patients with PD. Low scores on the FAB indicate patients with PD at high risk for PG.

Original languageEnglish
Pages (from-to)899-905
Number of pages7
JournalMovement Disorders
Volume24
Issue number6
DOIs
Publication statusPublished - Apr 30 2009

Fingerprint

Gambling
Parkinson Disease
Frontal Lobe
Cognitive Dysfunction
Trail Making Test
Long-Term Memory
Executive Function
Diagnostic and Statistical Manual of Mental Disorders
Dementia
Logistic Models
Odds Ratio

Keywords

  • Executive functions
  • Frontal lobe
  • Parkinson's disease
  • Pathological gambling

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Santangelo, G., Vitale, C., Trojano, L., Verde, F., Grossi, D., & Barone, P. (2009). Cognitive dysfunctions and Pathological gambling in patients with Parkinson's disease. Movement Disorders, 24(6), 899-905. https://doi.org/10.1002/mds.22472

Cognitive dysfunctions and Pathological gambling in patients with Parkinson's disease. / Santangelo, Gabriella; Vitale, Carmine; Trojano, Luigi; Verde, Francesca; Grossi, Dario; Barone, Paolo.

In: Movement Disorders, Vol. 24, No. 6, 30.04.2009, p. 899-905.

Research output: Contribution to journalArticle

Santangelo, G, Vitale, C, Trojano, L, Verde, F, Grossi, D & Barone, P 2009, 'Cognitive dysfunctions and Pathological gambling in patients with Parkinson's disease', Movement Disorders, vol. 24, no. 6, pp. 899-905. https://doi.org/10.1002/mds.22472
Santangelo G, Vitale C, Trojano L, Verde F, Grossi D, Barone P. Cognitive dysfunctions and Pathological gambling in patients with Parkinson's disease. Movement Disorders. 2009 Apr 30;24(6):899-905. https://doi.org/10.1002/mds.22472
Santangelo, Gabriella ; Vitale, Carmine ; Trojano, Luigi ; Verde, Francesca ; Grossi, Dario ; Barone, Paolo. / Cognitive dysfunctions and Pathological gambling in patients with Parkinson's disease. In: Movement Disorders. 2009 ; Vol. 24, No. 6. pp. 899-905.
@article{d3070f0a4329414d9bd500851f95e051,
title = "Cognitive dysfunctions and Pathological gambling in patients with Parkinson's disease",
abstract = "The purpose of this study was to investigate the neuropsychological correlates of pathological gambling (PG) in Parkinson's disease (PD). Fifteen patients with PD affected by PG (identified based on DSM-IV criteria; PD+PG) without clinically evident dementia were compared with 15 nondemented patients with PD not affected by PG (PD-PG). Two groups of patients with PD were matched for age, length of education, and gender. Clinical and neuropsychiatric features were assessed; several cognitive domains, mainly related to executive functions, were explored by means of standardized neuropsychological tasks. PD+PG and PD-PG did not differ on clinical and neuropsychiatric aspects. PD+PG patients performed significantly worse than PD-PG patients on cognitive tasks that evaluated visuo-spatial long-term memory and several frontal lobe functions. After Bonferroni correction, differences remained significant on the Frontal Assessment Battery (FAB) (P = 0.001), on phonological fluency task (P = 0.003), and on the Trail Making Test, part B minus part A (P = 0.002). Logistic regression analysis demonstrated that low scores on the FAB were the only independent predictor of PG (odds ratio, 27.9; 95{\%} CI: 2.82-277.95, P = 0.004). The results indicate an association between PG and frontal lobe dysfunctions in nondemented patients with PD. Low scores on the FAB indicate patients with PD at high risk for PG.",
keywords = "Executive functions, Frontal lobe, Parkinson's disease, Pathological gambling",
author = "Gabriella Santangelo and Carmine Vitale and Luigi Trojano and Francesca Verde and Dario Grossi and Paolo Barone",
year = "2009",
month = "4",
day = "30",
doi = "10.1002/mds.22472",
language = "English",
volume = "24",
pages = "899--905",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - Cognitive dysfunctions and Pathological gambling in patients with Parkinson's disease

AU - Santangelo, Gabriella

AU - Vitale, Carmine

AU - Trojano, Luigi

AU - Verde, Francesca

AU - Grossi, Dario

AU - Barone, Paolo

PY - 2009/4/30

Y1 - 2009/4/30

N2 - The purpose of this study was to investigate the neuropsychological correlates of pathological gambling (PG) in Parkinson's disease (PD). Fifteen patients with PD affected by PG (identified based on DSM-IV criteria; PD+PG) without clinically evident dementia were compared with 15 nondemented patients with PD not affected by PG (PD-PG). Two groups of patients with PD were matched for age, length of education, and gender. Clinical and neuropsychiatric features were assessed; several cognitive domains, mainly related to executive functions, were explored by means of standardized neuropsychological tasks. PD+PG and PD-PG did not differ on clinical and neuropsychiatric aspects. PD+PG patients performed significantly worse than PD-PG patients on cognitive tasks that evaluated visuo-spatial long-term memory and several frontal lobe functions. After Bonferroni correction, differences remained significant on the Frontal Assessment Battery (FAB) (P = 0.001), on phonological fluency task (P = 0.003), and on the Trail Making Test, part B minus part A (P = 0.002). Logistic regression analysis demonstrated that low scores on the FAB were the only independent predictor of PG (odds ratio, 27.9; 95% CI: 2.82-277.95, P = 0.004). The results indicate an association between PG and frontal lobe dysfunctions in nondemented patients with PD. Low scores on the FAB indicate patients with PD at high risk for PG.

AB - The purpose of this study was to investigate the neuropsychological correlates of pathological gambling (PG) in Parkinson's disease (PD). Fifteen patients with PD affected by PG (identified based on DSM-IV criteria; PD+PG) without clinically evident dementia were compared with 15 nondemented patients with PD not affected by PG (PD-PG). Two groups of patients with PD were matched for age, length of education, and gender. Clinical and neuropsychiatric features were assessed; several cognitive domains, mainly related to executive functions, were explored by means of standardized neuropsychological tasks. PD+PG and PD-PG did not differ on clinical and neuropsychiatric aspects. PD+PG patients performed significantly worse than PD-PG patients on cognitive tasks that evaluated visuo-spatial long-term memory and several frontal lobe functions. After Bonferroni correction, differences remained significant on the Frontal Assessment Battery (FAB) (P = 0.001), on phonological fluency task (P = 0.003), and on the Trail Making Test, part B minus part A (P = 0.002). Logistic regression analysis demonstrated that low scores on the FAB were the only independent predictor of PG (odds ratio, 27.9; 95% CI: 2.82-277.95, P = 0.004). The results indicate an association between PG and frontal lobe dysfunctions in nondemented patients with PD. Low scores on the FAB indicate patients with PD at high risk for PG.

KW - Executive functions

KW - Frontal lobe

KW - Parkinson's disease

KW - Pathological gambling

UR - http://www.scopus.com/inward/record.url?scp=67651154454&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67651154454&partnerID=8YFLogxK

U2 - 10.1002/mds.22472

DO - 10.1002/mds.22472

M3 - Article

C2 - 19205072

AN - SCOPUS:67651154454

VL - 24

SP - 899

EP - 905

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

IS - 6

ER -