Cognitive function in primary progressive and transitional progressive multiple sclerosis. A controlled study with MRI correlates

S. J. Camp, V. L. Stevenson, A. J. Thompson, D. H. Miller, C. Borras, S. Auriacombe, B. Brochet, M. Falautano, M. Filippi, L. Hérissé-Dulo, X. Montalban, E. Parrcira, C. H. Polman, J. De Sa, D. W. Langdon

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Abstract

The relative rarity of primary progressive (PP) and transitional progressive (TP) multiple sclerosis has meant that little documentation of cognitive function in such patients is currently available. The aim of this study was to investigate the cognitive skills of patients with PP and TP multiple sclerosis relative to matched healthy controls, and to examine the relationship of this impairment to MRI parameters. Sixty-three patients (43 PP, 20 TP) were individually matched with healthy controls, who undertook the same cognitive tasks as the patient group. The neuropsychological assessment comprised Rao's brief repeatable battery, a reasoning test, and a measure of depression. Patients also underwent T1- and T2-weighted brain MRI. These patients were taken from a larger cohort (158 PP, 33 TP) in whom it had been demonstrated that there were no significant differences between the mean scores of the PP and TP groups on any of the cognitive variables. The 63 patients were therefore taken as one group for comparison with the healthy controls. These patients performed significantly worse than the controls in tests of verbal memory, attention, verbal fluency and spatial reasoning. An impairment index was constructed and applied to the patient data. This correlated modestly with T2-lesion load (r = 0.45, P = 0.01), T1-hypointensity load (r = 0.45, P = 0.01), and cerebral volume (r = -0.35, P = 0.01). Thus, PP and TP multiple sclerosis patients demonstrate significant cognitive dysfunction when compared with matched healthy controls. The relationship between this impairment and MRI parameters is moderate, suggesting that cognitive dysfunction in PP and TP multiple sclerosis has a complex and multifactorial aetiology, which is not adequately explained by pathology as demonstrated on conventional MRI.

Original languageEnglish
Pages (from-to)1341-1348
Number of pages8
JournalBrain
Volume122
Issue number7
DOIs
Publication statusPublished - Jul 1999

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Cognition
Multiple Sclerosis
Documentation
Depression
Pathology
Brain

Keywords

  • Cognitive function
  • MRI
  • Multiple sclerosis
  • Primary progressive
  • Transitional progressive

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Camp, S. J., Stevenson, V. L., Thompson, A. J., Miller, D. H., Borras, C., Auriacombe, S., ... Langdon, D. W. (1999). Cognitive function in primary progressive and transitional progressive multiple sclerosis. A controlled study with MRI correlates. Brain, 122(7), 1341-1348. https://doi.org/10.1093/brain/122.7.1341

Cognitive function in primary progressive and transitional progressive multiple sclerosis. A controlled study with MRI correlates. / Camp, S. J.; Stevenson, V. L.; Thompson, A. J.; Miller, D. H.; Borras, C.; Auriacombe, S.; Brochet, B.; Falautano, M.; Filippi, M.; Hérissé-Dulo, L.; Montalban, X.; Parrcira, E.; Polman, C. H.; De Sa, J.; Langdon, D. W.

In: Brain, Vol. 122, No. 7, 07.1999, p. 1341-1348.

Research output: Contribution to journalArticle

Camp, SJ, Stevenson, VL, Thompson, AJ, Miller, DH, Borras, C, Auriacombe, S, Brochet, B, Falautano, M, Filippi, M, Hérissé-Dulo, L, Montalban, X, Parrcira, E, Polman, CH, De Sa, J & Langdon, DW 1999, 'Cognitive function in primary progressive and transitional progressive multiple sclerosis. A controlled study with MRI correlates', Brain, vol. 122, no. 7, pp. 1341-1348. https://doi.org/10.1093/brain/122.7.1341
Camp, S. J. ; Stevenson, V. L. ; Thompson, A. J. ; Miller, D. H. ; Borras, C. ; Auriacombe, S. ; Brochet, B. ; Falautano, M. ; Filippi, M. ; Hérissé-Dulo, L. ; Montalban, X. ; Parrcira, E. ; Polman, C. H. ; De Sa, J. ; Langdon, D. W. / Cognitive function in primary progressive and transitional progressive multiple sclerosis. A controlled study with MRI correlates. In: Brain. 1999 ; Vol. 122, No. 7. pp. 1341-1348.
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