Cognitive function in young and adult IL (interleukin)-6 deficient mice

Daniela Braida, Paola Sacerdote, Alberto E. Panerai, Mauro Bianchi, Anna Maria Aloisi, Stefania Iosuè, Mariaelvina Sala

Research output: Contribution to journalArticlepeer-review

Abstract

Interleukin-6 (IL-6) is a cytokine shown to affect brain function and to be involved in pathological neurodegenerative disorders such as Alzheimer's disease (AD). In the present study we investigated the cognitive function in transgenic mice not expressing IL-6 (IL-6 KO) and in wild type (WT) genotype at 4 and 12 months of age, using a passive avoidance and an eight-arm radial maze tasks. Motor function was quantified using an Animex apparatus. Hippocampal choline acetyltransferase (ChAT) activity was evaluated in both genotypes. No difference was observed in both genotypes for spontaneous motor activity. The mean latency (s) to re-enter the shock box, was similar in both young mutant and WT mice. However, a decreased sensitivity (50%) to scopolamine (1 mg/kg) in mutant compared to WT mice, was obtained. IL-6 KO mice exhibited a facilitation of radial maze learning over 30 days, in terms of a lower number of working memory errors and a higher percentage of animals reaching the criterion as compared with WT genotype tested at both ages. Furthermore, mutant mice, at the age of 12 months, showed a faster acquisition (22 days versus 30 days to reach the criterion). The pattern of arm entry exhibited by IL-6 KO mice showed a robust tendency to enter an adjacent arm at both ages, while WT only at the age of 4 months. ChAT activity was inversely correlated with memory performance. These findings suggest a possible involvement of IL-6 on memory processes, even if the mechanism remains still unclear.

Original languageEnglish
Pages (from-to)423-429
Number of pages7
JournalBehavioural Brain Research
Volume153
Issue number2
DOIs
Publication statusPublished - Aug 31 2004

Keywords

  • Interleukin-6
  • Knock out mice
  • Reference memory
  • Working memory

ASJC Scopus subject areas

  • Behavioral Neuroscience

Fingerprint

Dive into the research topics of 'Cognitive function in young and adult IL (interleukin)-6 deficient mice'. Together they form a unique fingerprint.

Cite this