Cognitive functions in adult down's syndrome

Research output: Contribution to journalArticle

Abstract

Cognitive profiles of performances were obtained from a selected group of adult Down syndrome (DS) subjects (n = 20; mean age: 34.5 years; s.d.: 7.7) by means of an ad hoc neuropsychological battery. With the aim of examining, from a neuropsychological point of view, the modifications that increasing age produces in this group of patients, cognitive performances of younger DS subjects (mean age: 28 years; s.d.: 4.77) were compared with analogous performances obtained by the older ones (mean age: 39.8 years; s.d.: 5.11). Subsequently, to clarify qualitative aspects of cognitive patterns in the subgroups of young and old DS subjects, two different groups of control patients were utilised. Neuropsychological data collected from a group of adult mentally retarded subjects were compared with cognitive performances demonstrated by young DS subjects, while the old group of DS subjects was analyzed in comparison with a group of patients affected by initial form of Alzheimer disease (AD). Altogether, the results of our study do not seem to support, from a neuropsychological point of view, the hypothesis that mental decline observed in DS subjects reproduces the cognitive patterns of impairment observed in AD patients.

Original languageEnglish
Pages (from-to)221-230
Number of pages10
JournalInternational Journal of Neuroscience
Volume54
Issue number3-4
DOIs
Publication statusPublished - 1990

Fingerprint

Down Syndrome
Cognition
Alzheimer Disease
Mentally Disabled Persons
Control Groups

Keywords

  • Aging
  • Alzheimer disease
  • Cognition
  • Down syndrome
  • Mental retardation
  • Neuropsychological assessment

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cognitive functions in adult down's syndrome. / Caltagirone, Carlo; Nocentini, Ugo; Vicari, Stefano.

In: International Journal of Neuroscience, Vol. 54, No. 3-4, 1990, p. 221-230.

Research output: Contribution to journalArticle

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