Cognitive functions in striato-nigral and olivo-ponto-cerebellar-type muttisystem atrophy

P. Soliveri, D. Monza, D. Paridi, S. Genitrini, D. Testa, F. Carella, T. Caraceni, F. Girotti

Research output: Contribution to journalArticlepeer-review


Deficit in frontal functions is well documented in striato-nigral-degeneration (SND) type multisystem atrophy (MSA). Other studies have shown deficits in planning, visuospatial, and linguistic functions in patients with cerebellar diseases. However no studies have compared cognitive functions in SND type and olivo-ponto-cerebellar (OPCA) type multisystem atrophy. We compared 7 SND patients, 7 OPCA patients, and 7 controls on a comprehensive neuropsychological battery. The groups did not differ in age or education; the OPCA and SND patients did not differ in disease duration or motor disability as assessed by NUDS. Non-parametric ANOVA showed significant differences between the groups in intelligence and reasoning (MMSE and Raven test), attention, constructive apraxia, ideomotor apraxia and executive functions. Post-hoc analysis showed that SND patients were worse than controls in reasoning, attention and ideomotor apraxia tests (although mean scores were not apraxic). OPCA patients were worse than controls in these measures, and also in the executive function and constructive apraxia tests. The SND and OPCA patients did not differ significantly in any cognitive functions. Lack of different cognitive profile in these two diseases could be due to the presence of subclinical signs of one disease in patients diagnosed with the other, or perhaps to small sample size. We are currently testing more patients to improve the power of our study.

Original languageEnglish
Pages (from-to)269
Number of pages1
JournalItalian Journal of Neurological Sciences
Issue number4
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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