Cognitive impairment and cardiovascular diseases in the elderly. A heart-brain continuum hypothesis

Pasquale Abete, David Della-Morte, Gaetano Gargiulo, Claudia Basile, Assunta Langellott, Gianluigi Galizia, Gianluca Testa, Canonico Vincenzo, Domenico Bonaduce, Francesco Cacciatore

Research output: Contribution to journalArticle

Abstract

The aging population is increasing and, therefore, a higher prevalence of cardiac disease is emerging; including hypertension, coronary artery disease, atrial fibrillation and chronic heart failure. Large cohort studies have revealed a relationship among increased risk for cognitive impairment and dementia in cardiovascular diseases probably due to embolic stroke or chronic cerebral hypoperfusion. Thus, the aim of the present review is to overview the studies that investigate the presence and/or the development of cognitive impairments and dementia in patients with varied types of cardiovascular disease. Finally, a continuum among hypertension, coronary artery disease, atrial fibrillation and chronic heart failure with to the development of cognitive impairment and progression to dementia has been hypothesized.

Original languageEnglish
Pages (from-to)41-52
Number of pages12
JournalAgeing Research Reviews
Volume18
DOIs
Publication statusPublished - 2014

Keywords

  • Cardiovascular disease
  • Cognitive impairment
  • Dementia

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Biotechnology
  • Molecular Biology
  • Neurology
  • Medicine(all)

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    Abete, P., Della-Morte, D., Gargiulo, G., Basile, C., Langellott, A., Galizia, G., Testa, G., Vincenzo, C., Bonaduce, D., & Cacciatore, F. (2014). Cognitive impairment and cardiovascular diseases in the elderly. A heart-brain continuum hypothesis. Ageing Research Reviews, 18, 41-52. https://doi.org/10.1016/j.arr.2014.07.003