Cognitive Impairment and Celiac Disease: Is Transcranial Magnetic Stimulation a Trait d'Union between Gut and Brain?

Giuseppe Lanza, Rita Bella, Mariagiovanna Cantone, Giovanni Pennisi, Raffaele Ferri, Manuela Pennisi

Research output: Contribution to journalReview article

Abstract

Celiac disease is a systemic disorder with multifactorial pathogenesis and multifaceted symptomatology. In response to gluten exposure, a significant part of the general population produces antibodies that have been hypothesized to be deleterious to the brain. Among the well-known neurological manifestations, adult celiac patients often complain cognitive symptoms, ranging from the so-called "brain fog" till an overt dementia. Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique that can contribute to the assessment and monitoring of celiac patients, even in those without a clear neurological involvement. The studies here reviewed seem to converge on an impaired central motor conductivity and a "hyperexcitable celiac brain" to TMS, which partially reverts back after a long-term gluten restriction. Notably, a clear hyperexcitability is a stably reported feature of both degenerative and vascular dementia. Therefore, given its potential neuroprotective effect, the gluten-free diet should be introduced as early as possible, although the overall response of neurological symptoms (and cognition in particular) is still controversial. Identifying new and possibly modifiable risk factors may be of crucial importance for patients, clinicians, and researchers.

Original languageEnglish
JournalInternational Journal of Molecular Sciences
Volume19
Issue number8
DOIs
Publication statusPublished - Jul 31 2018

Fingerprint

Transcranial Magnetic Stimulation
impairment
Celiac Disease
stimulation
brain
Glutens
Brain
Abdomen
cognition
Gluten-Free Diet
pathogenesis
diets
Neurobehavioral Manifestations
Vascular Dementia
fog
Weather
Physiologic Monitoring
Neuroprotective Agents
Fog
Nutrition

Keywords

  • Animals
  • Celiac Disease/metabolism
  • Cognitive Dysfunction/metabolism
  • Evoked Potentials, Motor/physiology
  • Humans
  • Transcranial Magnetic Stimulation

Cite this

Cognitive Impairment and Celiac Disease : Is Transcranial Magnetic Stimulation a Trait d'Union between Gut and Brain? / Lanza, Giuseppe; Bella, Rita; Cantone, Mariagiovanna; Pennisi, Giovanni; Ferri, Raffaele; Pennisi, Manuela.

In: International Journal of Molecular Sciences, Vol. 19, No. 8, 31.07.2018.

Research output: Contribution to journalReview article

Lanza, Giuseppe ; Bella, Rita ; Cantone, Mariagiovanna ; Pennisi, Giovanni ; Ferri, Raffaele ; Pennisi, Manuela. / Cognitive Impairment and Celiac Disease : Is Transcranial Magnetic Stimulation a Trait d'Union between Gut and Brain?. In: International Journal of Molecular Sciences. 2018 ; Vol. 19, No. 8.
@article{3bf9cd13e58a4c7f848c1f02ff67fa5a,
title = "Cognitive Impairment and Celiac Disease: Is Transcranial Magnetic Stimulation a Trait d'Union between Gut and Brain?",
abstract = "Celiac disease is a systemic disorder with multifactorial pathogenesis and multifaceted symptomatology. In response to gluten exposure, a significant part of the general population produces antibodies that have been hypothesized to be deleterious to the brain. Among the well-known neurological manifestations, adult celiac patients often complain cognitive symptoms, ranging from the so-called {"}brain fog{"} till an overt dementia. Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique that can contribute to the assessment and monitoring of celiac patients, even in those without a clear neurological involvement. The studies here reviewed seem to converge on an impaired central motor conductivity and a {"}hyperexcitable celiac brain{"} to TMS, which partially reverts back after a long-term gluten restriction. Notably, a clear hyperexcitability is a stably reported feature of both degenerative and vascular dementia. Therefore, given its potential neuroprotective effect, the gluten-free diet should be introduced as early as possible, although the overall response of neurological symptoms (and cognition in particular) is still controversial. Identifying new and possibly modifiable risk factors may be of crucial importance for patients, clinicians, and researchers.",
keywords = "Animals, Celiac Disease/metabolism, Cognitive Dysfunction/metabolism, Evoked Potentials, Motor/physiology, Humans, Transcranial Magnetic Stimulation",
author = "Giuseppe Lanza and Rita Bella and Mariagiovanna Cantone and Giovanni Pennisi and Raffaele Ferri and Manuela Pennisi",
year = "2018",
month = "7",
day = "31",
doi = "10.3390/ijms19082243",
language = "English",
volume = "19",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "MDPI AG",
number = "8",

}

TY - JOUR

T1 - Cognitive Impairment and Celiac Disease

T2 - Is Transcranial Magnetic Stimulation a Trait d'Union between Gut and Brain?

AU - Lanza, Giuseppe

AU - Bella, Rita

AU - Cantone, Mariagiovanna

AU - Pennisi, Giovanni

AU - Ferri, Raffaele

AU - Pennisi, Manuela

PY - 2018/7/31

Y1 - 2018/7/31

N2 - Celiac disease is a systemic disorder with multifactorial pathogenesis and multifaceted symptomatology. In response to gluten exposure, a significant part of the general population produces antibodies that have been hypothesized to be deleterious to the brain. Among the well-known neurological manifestations, adult celiac patients often complain cognitive symptoms, ranging from the so-called "brain fog" till an overt dementia. Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique that can contribute to the assessment and monitoring of celiac patients, even in those without a clear neurological involvement. The studies here reviewed seem to converge on an impaired central motor conductivity and a "hyperexcitable celiac brain" to TMS, which partially reverts back after a long-term gluten restriction. Notably, a clear hyperexcitability is a stably reported feature of both degenerative and vascular dementia. Therefore, given its potential neuroprotective effect, the gluten-free diet should be introduced as early as possible, although the overall response of neurological symptoms (and cognition in particular) is still controversial. Identifying new and possibly modifiable risk factors may be of crucial importance for patients, clinicians, and researchers.

AB - Celiac disease is a systemic disorder with multifactorial pathogenesis and multifaceted symptomatology. In response to gluten exposure, a significant part of the general population produces antibodies that have been hypothesized to be deleterious to the brain. Among the well-known neurological manifestations, adult celiac patients often complain cognitive symptoms, ranging from the so-called "brain fog" till an overt dementia. Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique that can contribute to the assessment and monitoring of celiac patients, even in those without a clear neurological involvement. The studies here reviewed seem to converge on an impaired central motor conductivity and a "hyperexcitable celiac brain" to TMS, which partially reverts back after a long-term gluten restriction. Notably, a clear hyperexcitability is a stably reported feature of both degenerative and vascular dementia. Therefore, given its potential neuroprotective effect, the gluten-free diet should be introduced as early as possible, although the overall response of neurological symptoms (and cognition in particular) is still controversial. Identifying new and possibly modifiable risk factors may be of crucial importance for patients, clinicians, and researchers.

KW - Animals

KW - Celiac Disease/metabolism

KW - Cognitive Dysfunction/metabolism

KW - Evoked Potentials, Motor/physiology

KW - Humans

KW - Transcranial Magnetic Stimulation

U2 - 10.3390/ijms19082243

DO - 10.3390/ijms19082243

M3 - Review article

C2 - 30065211

VL - 19

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 8

ER -