Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing-remitting multiple sclerosis

Baseline results from the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study

F. Patti, M. P. Amato, M. Trojano, S. Bastianello, M. R. Tola, B. Goretti, L. Caniatti, E. Di Monte, P. Ferrazza, V. Brescia Morra, S. Lo Fermo, O. Picconi, G. Luccichenti, R. Vecchio, D. Maimone, S. Messina, C. Gasperini, V. Orefice, C. Florio, E. Portaccio & 39 others V. Zipoli, A. Bertolotto, P. Bramanti, E. Sessa, D. Centonze, S. Cottone, G. Salemi, M. Falcini, P. Gallo, P. Perini, G. L. Gigli, G. Giuliani, L. M. Grimaldi, L. Murri, A. Lugaresi, F. Monaco, E. Montanari, L. Motti, S. Neri, M. Paciello, L. Provinciali, M. Ragno, G. Rosati, S. Ruggieri, M. R. Tola, P. Tonali, A. P. Batocchi, M. F. De Caro, A. Ghezzi, M. Zaffaroni, P. Zolo, M. Zorzon, M. Signorino, E. Scarpini, L. Durelli, A. Carolei, M. Todaro, D. Spitaleri, A. Tartaglione

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Background: Cognitive impairment is a common symptom of multiple sclerosis (MS), but the association between cognitive impairment and magnetic resonance imaging (MRI) disease measures in patients with relapsing-remitting (RR) MS is unclear. Objectives: To study the prevalence of cognitive impairment and its relation with MRI disease measures in mildly disabled patients with RRMS. Methods: Patients aged 18-50 years with RRMS (McDonald criteria) and an Expanded Disability Status Scale (EDSS) score ≤4.0, who were enrolled in the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study, underwent baseline standardized MRI complete neurological examination and neuropsychological testing. Results: A total of 550 patients were enrolled, 327 of whom underwent MRI assessments. Cognitive impairment (impaired performance in ≥3 cognitive tests) was present in approximately 20% of all patients and in the subgroup who underwent MRI. T2 hyperintense and T1 hypointense lesion volumes were significantly higher in patients with cognitive impairment (defined as impaired performance on at least three tests of the Rao's battery) than those without. EDSS score was also significantly higher in cognitively impaired than in cognitively preserved patients. Disease duration, depression, and years in formal education did not differ significantly between cognitively impaired and cognitively preserved patients. T2 lesion volume, performance intelligence quotient, and age were significant predictors of cognitive impairment in this population. Weak correlations were found between performance on individual cognitive tests and specific MRI measures, with T1 and T2 lesion volumes correlating with performance on most cognitive tests. Conclusions: Cognitive impairment occurs in approximately one-fifth of mildly disabled patients with MS and is associated with specific MRI disease measures. Assessment of cognitive function at diagnosis could facilitate the identification of patients who may benefit from therapeutic intervention with disease-modifying therapies to prevent further lesion development.

Original languageEnglish
Pages (from-to)779-788
Number of pages10
JournalMultiple Sclerosis Journal
Volume15
Issue number7
DOIs
Publication statusPublished - 2009

Fingerprint

Relapsing-Remitting Multiple Sclerosis
Multiple Sclerosis
Magnetic Resonance Imaging
Cognitive Dysfunction
Neurologic Examination
Intelligence
Cognition
Cross-Sectional Studies
Depression
Education

Keywords

  • Cognitive function
  • Cognitive impairment
  • Multiple sclerosis
  • Neuropsychological assessment

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing-remitting multiple sclerosis : Baseline results from the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study. / Patti, F.; Amato, M. P.; Trojano, M.; Bastianello, S.; Tola, M. R.; Goretti, B.; Caniatti, L.; Di Monte, E.; Ferrazza, P.; Brescia Morra, V.; Lo Fermo, S.; Picconi, O.; Luccichenti, G.; Vecchio, R.; Maimone, D.; Messina, S.; Gasperini, C.; Orefice, V.; Florio, C.; Portaccio, E.; Zipoli, V.; Bertolotto, A.; Bramanti, P.; Sessa, E.; Centonze, D.; Cottone, S.; Salemi, G.; Falcini, M.; Gallo, P.; Perini, P.; Gigli, G. L.; Giuliani, G.; Grimaldi, L. M.; Murri, L.; Lugaresi, A.; Monaco, F.; Montanari, E.; Motti, L.; Neri, S.; Paciello, M.; Provinciali, L.; Ragno, M.; Rosati, G.; Ruggieri, S.; Tola, M. R.; Tonali, P.; Batocchi, A. P.; De Caro, M. F.; Ghezzi, A.; Zaffaroni, M.; Zolo, P.; Zorzon, M.; Signorino, M.; Scarpini, E.; Durelli, L.; Carolei, A.; Todaro, M.; Spitaleri, D.; Tartaglione, A.

In: Multiple Sclerosis Journal, Vol. 15, No. 7, 2009, p. 779-788.

Research output: Contribution to journalArticle

Patti, F, Amato, MP, Trojano, M, Bastianello, S, Tola, MR, Goretti, B, Caniatti, L, Di Monte, E, Ferrazza, P, Brescia Morra, V, Lo Fermo, S, Picconi, O, Luccichenti, G, Vecchio, R, Maimone, D, Messina, S, Gasperini, C, Orefice, V, Florio, C, Portaccio, E, Zipoli, V, Bertolotto, A, Bramanti, P, Sessa, E, Centonze, D, Cottone, S, Salemi, G, Falcini, M, Gallo, P, Perini, P, Gigli, GL, Giuliani, G, Grimaldi, LM, Murri, L, Lugaresi, A, Monaco, F, Montanari, E, Motti, L, Neri, S, Paciello, M, Provinciali, L, Ragno, M, Rosati, G, Ruggieri, S, Tola, MR, Tonali, P, Batocchi, AP, De Caro, MF, Ghezzi, A, Zaffaroni, M, Zolo, P, Zorzon, M, Signorino, M, Scarpini, E, Durelli, L, Carolei, A, Todaro, M, Spitaleri, D & Tartaglione, A 2009, 'Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing-remitting multiple sclerosis: Baseline results from the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study', Multiple Sclerosis Journal, vol. 15, no. 7, pp. 779-788. https://doi.org/10.1177/1352458509105544
Patti, F. ; Amato, M. P. ; Trojano, M. ; Bastianello, S. ; Tola, M. R. ; Goretti, B. ; Caniatti, L. ; Di Monte, E. ; Ferrazza, P. ; Brescia Morra, V. ; Lo Fermo, S. ; Picconi, O. ; Luccichenti, G. ; Vecchio, R. ; Maimone, D. ; Messina, S. ; Gasperini, C. ; Orefice, V. ; Florio, C. ; Portaccio, E. ; Zipoli, V. ; Bertolotto, A. ; Bramanti, P. ; Sessa, E. ; Centonze, D. ; Cottone, S. ; Salemi, G. ; Falcini, M. ; Gallo, P. ; Perini, P. ; Gigli, G. L. ; Giuliani, G. ; Grimaldi, L. M. ; Murri, L. ; Lugaresi, A. ; Monaco, F. ; Montanari, E. ; Motti, L. ; Neri, S. ; Paciello, M. ; Provinciali, L. ; Ragno, M. ; Rosati, G. ; Ruggieri, S. ; Tola, M. R. ; Tonali, P. ; Batocchi, A. P. ; De Caro, M. F. ; Ghezzi, A. ; Zaffaroni, M. ; Zolo, P. ; Zorzon, M. ; Signorino, M. ; Scarpini, E. ; Durelli, L. ; Carolei, A. ; Todaro, M. ; Spitaleri, D. ; Tartaglione, A. / Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing-remitting multiple sclerosis : Baseline results from the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study. In: Multiple Sclerosis Journal. 2009 ; Vol. 15, No. 7. pp. 779-788.
@article{a7bbf01a012641f9b6ad008939f8a3af,
title = "Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing-remitting multiple sclerosis: Baseline results from the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study",
abstract = "Background: Cognitive impairment is a common symptom of multiple sclerosis (MS), but the association between cognitive impairment and magnetic resonance imaging (MRI) disease measures in patients with relapsing-remitting (RR) MS is unclear. Objectives: To study the prevalence of cognitive impairment and its relation with MRI disease measures in mildly disabled patients with RRMS. Methods: Patients aged 18-50 years with RRMS (McDonald criteria) and an Expanded Disability Status Scale (EDSS) score ≤4.0, who were enrolled in the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study, underwent baseline standardized MRI complete neurological examination and neuropsychological testing. Results: A total of 550 patients were enrolled, 327 of whom underwent MRI assessments. Cognitive impairment (impaired performance in ≥3 cognitive tests) was present in approximately 20{\%} of all patients and in the subgroup who underwent MRI. T2 hyperintense and T1 hypointense lesion volumes were significantly higher in patients with cognitive impairment (defined as impaired performance on at least three tests of the Rao's battery) than those without. EDSS score was also significantly higher in cognitively impaired than in cognitively preserved patients. Disease duration, depression, and years in formal education did not differ significantly between cognitively impaired and cognitively preserved patients. T2 lesion volume, performance intelligence quotient, and age were significant predictors of cognitive impairment in this population. Weak correlations were found between performance on individual cognitive tests and specific MRI measures, with T1 and T2 lesion volumes correlating with performance on most cognitive tests. Conclusions: Cognitive impairment occurs in approximately one-fifth of mildly disabled patients with MS and is associated with specific MRI disease measures. Assessment of cognitive function at diagnosis could facilitate the identification of patients who may benefit from therapeutic intervention with disease-modifying therapies to prevent further lesion development.",
keywords = "Cognitive function, Cognitive impairment, Multiple sclerosis, Neuropsychological assessment",
author = "F. Patti and Amato, {M. P.} and M. Trojano and S. Bastianello and Tola, {M. R.} and B. Goretti and L. Caniatti and {Di Monte}, E. and P. Ferrazza and {Brescia Morra}, V. and {Lo Fermo}, S. and O. Picconi and G. Luccichenti and R. Vecchio and D. Maimone and S. Messina and C. Gasperini and V. Orefice and C. Florio and E. Portaccio and V. Zipoli and A. Bertolotto and P. Bramanti and E. Sessa and D. Centonze and S. Cottone and G. Salemi and M. Falcini and P. Gallo and P. Perini and Gigli, {G. L.} and G. Giuliani and Grimaldi, {L. M.} and L. Murri and A. Lugaresi and F. Monaco and E. Montanari and L. Motti and S. Neri and M. Paciello and L. Provinciali and M. Ragno and G. Rosati and S. Ruggieri and Tola, {M. R.} and P. Tonali and Batocchi, {A. P.} and {De Caro}, {M. F.} and A. Ghezzi and M. Zaffaroni and P. Zolo and M. Zorzon and M. Signorino and E. Scarpini and L. Durelli and A. Carolei and M. Todaro and D. Spitaleri and A. Tartaglione",
year = "2009",
doi = "10.1177/1352458509105544",
language = "English",
volume = "15",
pages = "779--788",
journal = "Multiple Sclerosis",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",
number = "7",

}

TY - JOUR

T1 - Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing-remitting multiple sclerosis

T2 - Baseline results from the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study

AU - Patti, F.

AU - Amato, M. P.

AU - Trojano, M.

AU - Bastianello, S.

AU - Tola, M. R.

AU - Goretti, B.

AU - Caniatti, L.

AU - Di Monte, E.

AU - Ferrazza, P.

AU - Brescia Morra, V.

AU - Lo Fermo, S.

AU - Picconi, O.

AU - Luccichenti, G.

AU - Vecchio, R.

AU - Maimone, D.

AU - Messina, S.

AU - Gasperini, C.

AU - Orefice, V.

AU - Florio, C.

AU - Portaccio, E.

AU - Zipoli, V.

AU - Bertolotto, A.

AU - Bramanti, P.

AU - Sessa, E.

AU - Centonze, D.

AU - Cottone, S.

AU - Salemi, G.

AU - Falcini, M.

AU - Gallo, P.

AU - Perini, P.

AU - Gigli, G. L.

AU - Giuliani, G.

AU - Grimaldi, L. M.

AU - Murri, L.

AU - Lugaresi, A.

AU - Monaco, F.

AU - Montanari, E.

AU - Motti, L.

AU - Neri, S.

AU - Paciello, M.

AU - Provinciali, L.

AU - Ragno, M.

AU - Rosati, G.

AU - Ruggieri, S.

AU - Tola, M. R.

AU - Tonali, P.

AU - Batocchi, A. P.

AU - De Caro, M. F.

AU - Ghezzi, A.

AU - Zaffaroni, M.

AU - Zolo, P.

AU - Zorzon, M.

AU - Signorino, M.

AU - Scarpini, E.

AU - Durelli, L.

AU - Carolei, A.

AU - Todaro, M.

AU - Spitaleri, D.

AU - Tartaglione, A.

PY - 2009

Y1 - 2009

N2 - Background: Cognitive impairment is a common symptom of multiple sclerosis (MS), but the association between cognitive impairment and magnetic resonance imaging (MRI) disease measures in patients with relapsing-remitting (RR) MS is unclear. Objectives: To study the prevalence of cognitive impairment and its relation with MRI disease measures in mildly disabled patients with RRMS. Methods: Patients aged 18-50 years with RRMS (McDonald criteria) and an Expanded Disability Status Scale (EDSS) score ≤4.0, who were enrolled in the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study, underwent baseline standardized MRI complete neurological examination and neuropsychological testing. Results: A total of 550 patients were enrolled, 327 of whom underwent MRI assessments. Cognitive impairment (impaired performance in ≥3 cognitive tests) was present in approximately 20% of all patients and in the subgroup who underwent MRI. T2 hyperintense and T1 hypointense lesion volumes were significantly higher in patients with cognitive impairment (defined as impaired performance on at least three tests of the Rao's battery) than those without. EDSS score was also significantly higher in cognitively impaired than in cognitively preserved patients. Disease duration, depression, and years in formal education did not differ significantly between cognitively impaired and cognitively preserved patients. T2 lesion volume, performance intelligence quotient, and age were significant predictors of cognitive impairment in this population. Weak correlations were found between performance on individual cognitive tests and specific MRI measures, with T1 and T2 lesion volumes correlating with performance on most cognitive tests. Conclusions: Cognitive impairment occurs in approximately one-fifth of mildly disabled patients with MS and is associated with specific MRI disease measures. Assessment of cognitive function at diagnosis could facilitate the identification of patients who may benefit from therapeutic intervention with disease-modifying therapies to prevent further lesion development.

AB - Background: Cognitive impairment is a common symptom of multiple sclerosis (MS), but the association between cognitive impairment and magnetic resonance imaging (MRI) disease measures in patients with relapsing-remitting (RR) MS is unclear. Objectives: To study the prevalence of cognitive impairment and its relation with MRI disease measures in mildly disabled patients with RRMS. Methods: Patients aged 18-50 years with RRMS (McDonald criteria) and an Expanded Disability Status Scale (EDSS) score ≤4.0, who were enrolled in the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study, underwent baseline standardized MRI complete neurological examination and neuropsychological testing. Results: A total of 550 patients were enrolled, 327 of whom underwent MRI assessments. Cognitive impairment (impaired performance in ≥3 cognitive tests) was present in approximately 20% of all patients and in the subgroup who underwent MRI. T2 hyperintense and T1 hypointense lesion volumes were significantly higher in patients with cognitive impairment (defined as impaired performance on at least three tests of the Rao's battery) than those without. EDSS score was also significantly higher in cognitively impaired than in cognitively preserved patients. Disease duration, depression, and years in formal education did not differ significantly between cognitively impaired and cognitively preserved patients. T2 lesion volume, performance intelligence quotient, and age were significant predictors of cognitive impairment in this population. Weak correlations were found between performance on individual cognitive tests and specific MRI measures, with T1 and T2 lesion volumes correlating with performance on most cognitive tests. Conclusions: Cognitive impairment occurs in approximately one-fifth of mildly disabled patients with MS and is associated with specific MRI disease measures. Assessment of cognitive function at diagnosis could facilitate the identification of patients who may benefit from therapeutic intervention with disease-modifying therapies to prevent further lesion development.

KW - Cognitive function

KW - Cognitive impairment

KW - Multiple sclerosis

KW - Neuropsychological assessment

UR - http://www.scopus.com/inward/record.url?scp=67649311963&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649311963&partnerID=8YFLogxK

U2 - 10.1177/1352458509105544

DO - 10.1177/1352458509105544

M3 - Article

VL - 15

SP - 779

EP - 788

JO - Multiple Sclerosis

JF - Multiple Sclerosis

SN - 1352-4585

IS - 7

ER -