Cognitive impairment and risk of cardiovascular events and mortality.

Martin O'Donnell, Koon Teo, Peggy Gao, Craig Anderson, Peter Sleight, Antonio Dans, Irene Marzona, Jackie Bosch, Jeff Probstfield, Salim Yusuf

Research output: Contribution to journalArticlepeer-review


Cognitive impairment may increase the risk of all cardiovascular (CV) events. We prospectively evaluated the independent association between Mini-Mental State Examination (MMSE) score and myocardial infarction, stroke, hospital admission for heart failure and mortality, and their CV composite (major CV events), in a large high-risk CV population. Mini-Mental State Examination was recorded at baseline in 30 959 individuals enrolled into two large parallel trials of patients with prior cardiovascular disease or high-risk diabetes and followed for a median of 56 months. We used a Cox regression model to determine the association between MMSE score and incident CV events and non-CV mortality, adjusted for age, sex, education, history of vascular events, dietary factors, blood pressure, smoking, glucose, low-density lipoprotein, high-density lipoprotein, CV medications, exercise, alcohol intake pattern, depression, and psychosocial stress. Patients were categorized into four groups based on baseline MMSE; 30 (reference), 29-27, 26-24, and

Original languageEnglish
Pages (from-to)1777-1786
Number of pages10
JournalEuropean Heart Journal
Issue number14
Publication statusPublished - Jul 2012

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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