Cognitive impairment in adult myotonic dystrophies: A longitudinal study

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The clinical relevance and extent of cognitive impairment in adult myotonic dystrophy type 1 (DM1) and 2 (DM2) is still unclear. The aim of this study was to determine whether previously reported cognitive abnormalities progress over time and if this occurs in DM2 as it does in DM1. Fifty-six patients with DM1 and 29 patients with DM2 were subjected to muscle strength assessment, and to a complete battery of neuropsychological tests. Repeated assessment was performed in 20 DM1 and 13 DM2 over time (DM1 mean follow-up: 7.3±2.7 years; DM2 mean follow- up: 9.5±2.4 years). Muscle strength and test scores for frontal lobe functions worsened significantly over time (p

Original languageEnglish
Pages (from-to)9-15
Number of pages7
JournalNeurological Sciences
Volume28
Issue number1
DOIs
Publication statusPublished - Mar 2007

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Myotonic Dystrophy
Longitudinal Studies
Muscle Strength
Neuropsychological Tests
Frontal Lobe
Cognitive Dysfunction

Keywords

  • Dementia
  • Dysexecutive syndrome
  • Follow-up
  • Myotonic dystrophy type 1
  • Myotonic dystrophy type 2

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Cognitive impairment in adult myotonic dystrophies : A longitudinal study. / Sansone, V.; Gandossini, S.; Cotelli, M.; Calabria, M.; Zanetti, O.; Meola, Giovanni.

In: Neurological Sciences, Vol. 28, No. 1, 03.2007, p. 9-15.

Research output: Contribution to journalArticle

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