Cognitive impairment in multiple system atrophy: A position statement by the neuropsychology task force of the MDS multiple system atrophy (MODIMSA) study group

Iva Stankovic, Florian Krismer, Aleksandar Jesic, Angelo Antonini, Thomas Benke, Richard G. Brown, David J. Burn, Janice L. Holton, Horacio Kaufmann, Vladimir S. Kostic, Helen Ling, Wassilios G. Meissner, Werner Poewe, Marija Semnic, Klaus Seppi, Atsushi Takeda, Daniel Weintraub, Gregor K. Wenning

Research output: Contribution to journalArticle

Abstract

Consensus diagnostic criteria for multiple system atrophy consider dementia as a nonsupporting feature, despite emerging evidence demonstrating that cognitive impairments are an integral part of the disease. Cognitive disturbances in multiple system atrophy occur across a wide spectrum from mild single domain deficits to impairments in multiple domains and even to frank dementia in some cases. Frontal-executive dysfunction is the most common presentation, while memory and visuospatial functions also may be impaired. Imaging and neuropathological findings support the concept that cognitive impairments in MSA originate from striatofrontal deafferentation, with additional contributions from intrinsic cortical degeneration and cerebellar pathology. Based on a comprehensive evidence-based review, the authors propose future avenues of research that ultimately may lead to diagnostic criteria for cognitive impairment and dementia associated with multiple system atrophy.

Original languageEnglish
Pages (from-to)857-867
Number of pages11
JournalMovement Disorders
Volume29
Issue number7
DOIs
Publication statusPublished - 2014

Keywords

  • Cognition
  • Multiple system atrophy
  • Neuropsychology

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

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    Stankovic, I., Krismer, F., Jesic, A., Antonini, A., Benke, T., Brown, R. G., Burn, D. J., Holton, J. L., Kaufmann, H., Kostic, V. S., Ling, H., Meissner, W. G., Poewe, W., Semnic, M., Seppi, K., Takeda, A., Weintraub, D., & Wenning, G. K. (2014). Cognitive impairment in multiple system atrophy: A position statement by the neuropsychology task force of the MDS multiple system atrophy (MODIMSA) study group. Movement Disorders, 29(7), 857-867. https://doi.org/10.1002/mds.25880