Cognitive impairment in paediatric multiple sclerosis patients is not related to cortical lesions

Maria A. Rocca; Ermelinda De Meo; Maria P. Amato; Massimiliano Copetti; Lucia Moiola; Angelo Ghezzi; Pierangelo Veggiotti; Ruggero Capra; Agnese Fiorino; Lorena Pippolo; Maria C. Pera; Andrea Falini; Giancarlo Comi; Massimo Filippi

doi:10.1177/1352458514557303

Cognitive impairment in paediatric multiple sclerosis patients is not related to cortical lesions

Maria A. Rocca, Ermelinda De Meo, Maria P. Amato, Massimiliano Copetti, Lucia Moiola, Angelo Ghezzi, Pierangelo Veggiotti, Ruggero Capra, Agnese Fiorino, Lorena Pippolo, Maria C. Pera, Andrea Falini, Giancarlo Comi, Massimo Filippi

Research output: Contribution to journal › Article

Abstract

We investigated the contribution of cortical lesions to cognitive impairment in 41 paediatric MS patients. Thirteen (32%) paediatric MS patients were considered as cognitively impaired. T2-hyperintense and T1-hypointense white matter lesion volumes did not differ between cognitively impaired and cognitively preserved MS patients. Cortical lesions number, cortical lesions volume and grey matter volume did not differ between cognitively impaired and cognitively preserved patients, whereas white matter volume was significantly lower in cognitively impaired versus cognitively preserved MS patients (p=0.01). Contrary to adult MS, cortical lesions do not seem to contribute to cognitive impairment in paediatric MS patients, which is likely driven by white matter damage.

Original language	English
Pages (from-to)	956-959
Number of pages	4
Journal	Multiple Sclerosis Journal
Volume	21
Issue number	7
DOIs	https://doi.org/10.1177/1352458514557303
Publication status	Published - Jun 6 2015

Keywords

cortical lesions
double inversion recovery
grey matter
MRI
Paediatric multiple sclerosis

ASJC Scopus subject areas

Clinical Neurology
Neurology

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Rocca, M. A., De Meo, E., Amato, M. P., Copetti, M., Moiola, L., Ghezzi, A., Veggiotti, P., Capra, R., Fiorino, A., Pippolo, L., Pera, M. C., Falini, A., Comi, G., & Filippi, M. (2015). Cognitive impairment in paediatric multiple sclerosis patients is not related to cortical lesions. Multiple Sclerosis Journal, 21(7), 956-959. https://doi.org/10.1177/1352458514557303

Cognitive impairment in paediatric multiple sclerosis patients is not related to cortical lesions. / Rocca, Maria A.; De Meo, Ermelinda; Amato, Maria P.; Copetti, Massimiliano ; Moiola, Lucia; Ghezzi, Angelo; Veggiotti, Pierangelo; Capra, Ruggero; Fiorino, Agnese; Pippolo, Lorena; Pera, Maria C.; Falini, Andrea ; Comi, Giancarlo ; Filippi, Massimo.

In: Multiple Sclerosis Journal, Vol. 21, No. 7, 06.06.2015, p. 956-959.

Research output: Contribution to journal › Article

Rocca, Maria A. ; De Meo, Ermelinda ; Amato, Maria P. ; Copetti, Massimiliano ; Moiola, Lucia ; Ghezzi, Angelo ; Veggiotti, Pierangelo ; Capra, Ruggero ; Fiorino, Agnese ; Pippolo, Lorena ; Pera, Maria C. ; Falini, Andrea ; Comi, Giancarlo ; Filippi, Massimo. / Cognitive impairment in paediatric multiple sclerosis patients is not related to cortical lesions. In: Multiple Sclerosis Journal. 2015 ; Vol. 21, No. 7. pp. 956-959.

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abstract = "We investigated the contribution of cortical lesions to cognitive impairment in 41 paediatric MS patients. Thirteen (32%) paediatric MS patients were considered as cognitively impaired. T2-hyperintense and T1-hypointense white matter lesion volumes did not differ between cognitively impaired and cognitively preserved MS patients. Cortical lesions number, cortical lesions volume and grey matter volume did not differ between cognitively impaired and cognitively preserved patients, whereas white matter volume was significantly lower in cognitively impaired versus cognitively preserved MS patients (p=0.01). Contrary to adult MS, cortical lesions do not seem to contribute to cognitive impairment in paediatric MS patients, which is likely driven by white matter damage.",

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