Cognitive profile in Duchenne muscular dystrophy boys without intellectual disability: The role of executive functions

R. Battini, D. Chieffo, S. Bulgheroni, G. Piccini, C. Pecini, S. Lucibello, S. Lenzi, F. Moriconi, M. Pane, G. Astrea, G. Baranello, P. Alfieri, S. Vicari, D. Riva, G. Cioni, E. Mercuri

Research output: Contribution to journalArticle

Abstract

The aim of our prospective observational study was to assess profiles of cognitive function and a possible impairment of executive functions in a cohort of boys with Duchenne muscular dystrophy without intellectual and behavior disability. Forty Duchenne boys (range of age: 6 years to 11 years and 6 months) were assessed by Wechsler Intelligence scale and battery of tests including tasks assessing working memory and executive functions (inhibition and switching, problem solving and planning). In our cohort some aspects of cognitive function were often impaired. These included multitasking, problem solving, inhibition and working memory necessary to plan and direct goal oriented behavior. Our results support the suggestion that aspects of cognitive function could be impaired even in boys without intellectual disability and support the hypothesis that executive functions may play an important role in specific aspects of cognitive impairment in Duchenne muscular dystrophy. © 2017 Elsevier B.V.
Original languageEnglish
Pages (from-to)122-128
Number of pages7
JournalNeuromuscular Disorders
Volume28
Issue number2
DOIs
Publication statusPublished - 2018

Keywords

  • Article
  • behavior
  • behavior disorder
  • child
  • clinical article
  • cognition
  • cognitive defect
  • cohort analysis
  • controlled study
  • Duchenne muscular dystrophy
  • executive function
  • human
  • inhibition (psychology)
  • intellectual impairment
  • language
  • male
  • mental task
  • observational study
  • planning
  • priority journal
  • problem solving
  • prospective study
  • Wechsler intelligence scale for children
  • working memory

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