Cognitive Rehabilitation in Parkinson's Disease: Is it Feasible?

Roberta Biundo, Luca Weis, Eleonora Fiorenzato, Angelo Antonini

Research output: Contribution to journalReview articlepeer-review


Parkinson's disease (PD) is a common neurodegenerative disorder, characterized by motor and non-motor symptoms. Dementia is one of the most relevant non-motor symptoms considering its functional affect on PD patients' activities of daily living and family members' wellbeing. Cognitive abnormalities in PD are heterogeneous and reliable biomarkers to detect patients at risk for dementia early on remain to be identified. Pharmacological treatments specifically for PD dementia and mild cognitive impairment are lacking, and alternative approaches have recently been implemented, including cognitive rehabilitation. The state of the art indicates that cognitive rehabilitation is feasible in PD and may either improve or preserve cognitive performance over time. Advances in this area depend on selection of patients with a homogeneous cognitive phenotype as well as definition of appropriate timing of intervention and clinical variables. This review also discusses the application of non-invasive brain stimulation (NIBS) techniques, including transcranial direct current stimulation (tDCS), to enhance the effect of cognitive rehabilitation. However, there is need for a broad consensus about standard treatment guidelines to properly compare efficacy of these procedures and implement them in routine clinical practice.

Original languageEnglish
Pages (from-to)840-860
Number of pages21
JournalArchives of Clinical Neuropsychology
Issue number7
Publication statusPublished - Nov 1 2017


  • Computer-based cognitive training
  • Dementia
  • Mild cognitive impairment
  • Parkinson's disease
  • Rehabilitation
  • Transcranial stimulation

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Clinical Psychology
  • Psychiatry and Mental health


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