Cognitive reserve in dementia: Implications for cognitive training

Sara Mondini, Ileana Madella, Andrea Zangrossi, Angela Bigolin, Claudia Tomasi, Marta Michieletto, Daniele Villani, Giuseppina Di Giovanni, Daniela Mapelli

Research output: Contribution to journalArticlepeer-review


Cognitive reserve (CR) is a potential mechanism to cope with brain damage. The aim of this study was to evaluate the effect of CR on a cognitive training (CT) in a group of patients with dementia. Eighty six participants with mild to moderate dementia were identified by their level of CR quantified by the CR Index questionnaire (CRIq) and underwent a cycle of CT. A global measure of cognition mini mental state examination (MMSE) was obtained before (T0) and after (T1) the training. Multiple linear regression analyses highlighted CR as a significant factor able to predict changes in cognitive performance after the CT. In particular, patients with lower CR benefited from a CT program more than those with high CR. These data show that CR can modulate the outcome of a CT program and that it should be considered as a predictive factor of neuropsychological rehabilitation training efficacy in people with dementia.

Original languageEnglish
Article number84
JournalFrontiers in Aging Neuroscience
Issue numberAPR
Publication statusPublished - 2016


  • Alzheimer's disease
  • Cognitive reserve
  • Cognitive training
  • Dementia
  • Rehabilitation

ASJC Scopus subject areas

  • Ageing
  • Cognitive Neuroscience

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