Cognitive Reserve in Granulin-Related Frontotemporal Dementia

From Preclinical to Clinical Stages

Enrico Premi, Stefano Gazzina, Marco Bozzali, Silvana Archetti, Antonella Alberici, Mara Cercignani, Angelo Bianchetti, Roberto Gasparotti, Marinella Turla, Carlo Caltagirone, Alessandro Padovani, Barbara Borroni

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective:Consistent with the cognitive reserve hypothesis, higher education and occupation attainments may help persons with neurodegenerative dementias to better withstand neuropathology before developing cognitive impairment. We tested here the cognitive reserve hypothesis in patients with frontotemporal dementia (FTD), with or without pathogenetic granulin mutations (GRN+ and GRN-), and in presymptomatic GRN mutation carriers (aGRN+).Methods:Education and occupation attainments were assessed and combined to define Reserve Index (RI) in 32 FTD patients, i.e. 12 GRN+ and 20 GRN-, and in 17 aGRN+. Changes in functional connectivity were estimated by resting state fMRI, focusing on the salience network (SN), executive network (EN) and bilateral frontoparietal networks (FPNs). Cognitive status was measured by FTD-modified Clinical Dementia Rating Scale.Results:In FTD patients higher level of premorbid cognitive reserve was associated with reduced connectivity within the SN and the EN. EN was more involved in FTD patients without GRN mutations, while SN was more affected in GRN pathology. In aGRN+, cognitive reserve was associated with reduced SN.Conclusions:This study suggests that cognitive reserve modulates functional connectivity in patients with FTD, even in monogenic disease. In GRN inherited FTD, cognitive reserve mechanisms operate even in presymptomatic to clinical stages.

Original languageEnglish
Article numbere74762
JournalPLoS One
Volume8
Issue number9
DOIs
Publication statusPublished - Sep 9 2013

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Cognitive Reserve
Frontotemporal Dementia
dementia
Education
Pathology
Occupations
Mutation
Dementia
mutation
neuropathology
granulin precursor protein
rating scales
higher education
Magnetic Resonance Imaging
education

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Cognitive Reserve in Granulin-Related Frontotemporal Dementia : From Preclinical to Clinical Stages. / Premi, Enrico; Gazzina, Stefano; Bozzali, Marco; Archetti, Silvana; Alberici, Antonella; Cercignani, Mara; Bianchetti, Angelo; Gasparotti, Roberto; Turla, Marinella; Caltagirone, Carlo; Padovani, Alessandro; Borroni, Barbara.

In: PLoS One, Vol. 8, No. 9, e74762, 09.09.2013.

Research output: Contribution to journalArticle

Premi, E, Gazzina, S, Bozzali, M, Archetti, S, Alberici, A, Cercignani, M, Bianchetti, A, Gasparotti, R, Turla, M, Caltagirone, C, Padovani, A & Borroni, B 2013, 'Cognitive Reserve in Granulin-Related Frontotemporal Dementia: From Preclinical to Clinical Stages', PLoS One, vol. 8, no. 9, e74762. https://doi.org/10.1371/journal.pone.0074762
Premi, Enrico ; Gazzina, Stefano ; Bozzali, Marco ; Archetti, Silvana ; Alberici, Antonella ; Cercignani, Mara ; Bianchetti, Angelo ; Gasparotti, Roberto ; Turla, Marinella ; Caltagirone, Carlo ; Padovani, Alessandro ; Borroni, Barbara. / Cognitive Reserve in Granulin-Related Frontotemporal Dementia : From Preclinical to Clinical Stages. In: PLoS One. 2013 ; Vol. 8, No. 9.
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