Cognitive reserve is a determinant of social and occupational attainment in patients with pediatric and adult onset multiple sclerosis: Multiple Sclerosis and Related Disorders

P. E, S. M, B. A, P. L, N. M, R. L, F. R, T. L, F. M, G. A, M. MG, C. E, F. G, P. F, C. C, M. L, M. E, V. RG, G. B, A. MPMonica Falautano

Research output: Contribution to journalArticlepeer-review

Abstract

Background: There is limited information on socio-professional attainment in pediatric-onset multiple sclerosis (POMS) compared with adult-onset MS (AOMS). Objectives: To assess socio-professional outcomes in POMS and AOMS and variables influencing these outcomes. Methods: One-hundred-fifteen AOMS and 111 POMS patients underwent neuropsychological testing (Brief Repeatable Battery, Stroop test), assessment of cognitive reserve (CR) (education, National Adult reading Test –NART, Barratt Simplified Measure of Social Status), fatigue (Fatigue Severity Scale), depression (Montgomery-Åsberg Depression Rating Scale), socio-professional performance (Work and Social Adjustment Scale -WSAS). Prognostic factors were assessed using logistic and linear multivariable regression analyses. Results: 34.5% of patients showed CI without significant differences between AOMS and POMS. Cognitively impaired patients were older (p=0.024), had higher EDSS scores (p=0.041) and lower IQ (p
Original languageEnglish
JournalMult. Scler. Relat. Disord.
Volume42
DOIs
Publication statusPublished - 2020

Keywords

  • Adult onset multiple sclerosis
  • Cognitive performances
  • Cognitive reserve
  • Pediatric onset multiple sclerosis
  • Socio-professional outcomes
  • adult
  • Article
  • Barratt Simplified Measure of Social Status
  • Brief Repeatable Battery
  • cognitive reserve
  • comorbidity
  • controlled study
  • disease duration
  • Expanded Disability Status Scale
  • Fatigue Severity Scale
  • female
  • human
  • intelligence quotient
  • major clinical study
  • male
  • mental capacity
  • mental performance
  • Montgomery Asberg Depression Rating Scale
  • multiple sclerosis
  • national adult reading test
  • neuropsychological test
  • occupational health
  • onset age
  • social behavior
  • Stroop test

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