Cognitive reserve is a determinant of social and occupational attainment in patients with pediatric and adult onset multiple sclerosis: Multiple Sclerosis and Related Disorders

P. E; S. M; B. A; P. L; N. M; R. L; F. R; T. L; F. M; G. A; M. MG; C. E; F. G; P. F; C. C; M. L; M. E; V. RG; G. B; A. MP; Monica Falautano

doi:10.1016/j.msard.2020.102145

Cognitive reserve is a determinant of social and occupational attainment in patients with pediatric and adult onset multiple sclerosis: Multiple Sclerosis and Related Disorders

P. E, S. M, B. A, P. L, N. M, R. L, F. R, T. L, F. M, G. A, M. MG, C. E, F. G, P. F, C. C, M. L, M. E, V. RG, G. B, A. MPMonica Falautano

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Background: There is limited information on socio-professional attainment in pediatric-onset multiple sclerosis (POMS) compared with adult-onset MS (AOMS). Objectives: To assess socio-professional outcomes in POMS and AOMS and variables influencing these outcomes. Methods: One-hundred-fifteen AOMS and 111 POMS patients underwent neuropsychological testing (Brief Repeatable Battery, Stroop test), assessment of cognitive reserve (CR) (education, National Adult reading Test –NART, Barratt Simplified Measure of Social Status), fatigue (Fatigue Severity Scale), depression (Montgomery-Åsberg Depression Rating Scale), socio-professional performance (Work and Social Adjustment Scale -WSAS). Prognostic factors were assessed using logistic and linear multivariable regression analyses. Results: 34.5% of patients showed CI without significant differences between AOMS and POMS. Cognitively impaired patients were older (p=0.024), had higher EDSS scores (p=0.041) and lower IQ (p

Original language	English
Journal	Mult. Scler. Relat. Disord.
Volume	42
DOIs	https://doi.org/10.1016/j.msard.2020.102145
Publication status	Published - 2020

Keywords

Adult onset multiple sclerosis
Cognitive performances
Cognitive reserve
Pediatric onset multiple sclerosis
Socio-professional outcomes
adult
Article
Barratt Simplified Measure of Social Status
Brief Repeatable Battery
cognitive reserve
comorbidity
controlled study
disease duration
Expanded Disability Status Scale
Fatigue Severity Scale
female
human
intelligence quotient
major clinical study
male
mental capacity
mental performance
Montgomery Asberg Depression Rating Scale
multiple sclerosis
national adult reading test
neuropsychological test
occupational health
onset age
social behavior
Stroop test

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10.1016/j.msard.2020.102145

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85084377359&doi=10.1016%2fj.msard.2020.102145&partnerID=40&md5=f9bc7d62a54743244ce529d3bddabcaf

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E, P., M, S., A, B., L, P., M, N., L, R., R, F., L, T., M, F., A, G., MG, M., E, C., G, F., F, P., C, C., L, M., E, M., RG, V., B, G., ... Falautano, M. (2020). Cognitive reserve is a determinant of social and occupational attainment in patients with pediatric and adult onset multiple sclerosis: Multiple Sclerosis and Related Disorders. Mult. Scler. Relat. Disord., 42. https://doi.org/10.1016/j.msard.2020.102145

E, P, M, S, A, B, L, P, M, N, L, R, R, F, L, T, M, F, A, G, MG, M, E, C, G, F, F, P, C, C, L, M, E, M, RG, V, B, G, MP, A & Falautano, M 2020, 'Cognitive reserve is a determinant of social and occupational attainment in patients with pediatric and adult onset multiple sclerosis: Multiple Sclerosis and Related Disorders', Mult. Scler. Relat. Disord., vol. 42. https://doi.org/10.1016/j.msard.2020.102145

@article{b9584c7326ca40a6aa66105e841275d6,

title = "Cognitive reserve is a determinant of social and occupational attainment in patients with pediatric and adult onset multiple sclerosis: Multiple Sclerosis and Related Disorders",

abstract = "Background: There is limited information on socio-professional attainment in pediatric-onset multiple sclerosis (POMS) compared with adult-onset MS (AOMS). Objectives: To assess socio-professional outcomes in POMS and AOMS and variables influencing these outcomes. Methods: One-hundred-fifteen AOMS and 111 POMS patients underwent neuropsychological testing (Brief Repeatable Battery, Stroop test), assessment of cognitive reserve (CR) (education, National Adult reading Test –NART, Barratt Simplified Measure of Social Status), fatigue (Fatigue Severity Scale), depression (Montgomery-{\AA}sberg Depression Rating Scale), socio-professional performance (Work and Social Adjustment Scale -WSAS). Prognostic factors were assessed using logistic and linear multivariable regression analyses. Results: 34.5% of patients showed CI without significant differences between AOMS and POMS. Cognitively impaired patients were older (p=0.024), had higher EDSS scores (p=0.041) and lower IQ (p",

keywords = "Adult onset multiple sclerosis, Cognitive performances, Cognitive reserve, Pediatric onset multiple sclerosis, Socio-professional outcomes, adult, Article, Barratt Simplified Measure of Social Status, Brief Repeatable Battery, cognitive reserve, comorbidity, controlled study, disease duration, Expanded Disability Status Scale, Fatigue Severity Scale, female, human, intelligence quotient, major clinical study, male, mental capacity, mental performance, Montgomery Asberg Depression Rating Scale, multiple sclerosis, national adult reading test, neuropsychological test, occupational health, onset age, social behavior, Stroop test",

author = "P. E and S. M and B. A and P. L and N. M and R. L and F. R and T. L and F. M and G. A and M. MG and C. E and F. G and P. F and C. C and M. L and M. E and V. RG and G. B and A. MP and Monica Falautano",

note = "Export Date: 11 March 2021 Correspondence Address: M, S.; Child Neuropsychiatric Unit, Policlinico Piazza G. Cesare, 11, Italy; email: marta.simone@uniba.it Funding details: Fondazione Italiana Sclerosi Multipla, FISM Funding text 1: the study was funded by the Italian Multiple Sclerosis Foundation (FISM).",

year = "2020",

doi = "10.1016/j.msard.2020.102145",

language = "English",

volume = "42",

journal = "Mult. Scler. Relat. Disord.",

issn = "2211-0348",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Cognitive reserve is a determinant of social and occupational attainment in patients with pediatric and adult onset multiple sclerosis

T2 - Multiple Sclerosis and Related Disorders

AU - E, P.

AU - M, S.

AU - A, B.

AU - L, P.

AU - M, N.

AU - L, R.

AU - R, F.

AU - L, T.

AU - M, F.

AU - A, G.

AU - MG, M.

AU - E, C.

AU - G, F.

AU - F, P.

AU - C, C.

AU - L, M.

AU - E, M.

AU - RG, V.

AU - B, G.

AU - MP, A.

AU - Falautano, Monica

N1 - Export Date: 11 March 2021 Correspondence Address: M, S.; Child Neuropsychiatric Unit, Policlinico Piazza G. Cesare, 11, Italy; email: marta.simone@uniba.it Funding details: Fondazione Italiana Sclerosi Multipla, FISM Funding text 1: the study was funded by the Italian Multiple Sclerosis Foundation (FISM).

PY - 2020

Y1 - 2020

N2 - Background: There is limited information on socio-professional attainment in pediatric-onset multiple sclerosis (POMS) compared with adult-onset MS (AOMS). Objectives: To assess socio-professional outcomes in POMS and AOMS and variables influencing these outcomes. Methods: One-hundred-fifteen AOMS and 111 POMS patients underwent neuropsychological testing (Brief Repeatable Battery, Stroop test), assessment of cognitive reserve (CR) (education, National Adult reading Test –NART, Barratt Simplified Measure of Social Status), fatigue (Fatigue Severity Scale), depression (Montgomery-Åsberg Depression Rating Scale), socio-professional performance (Work and Social Adjustment Scale -WSAS). Prognostic factors were assessed using logistic and linear multivariable regression analyses. Results: 34.5% of patients showed CI without significant differences between AOMS and POMS. Cognitively impaired patients were older (p=0.024), had higher EDSS scores (p=0.041) and lower IQ (p

AB - Background: There is limited information on socio-professional attainment in pediatric-onset multiple sclerosis (POMS) compared with adult-onset MS (AOMS). Objectives: To assess socio-professional outcomes in POMS and AOMS and variables influencing these outcomes. Methods: One-hundred-fifteen AOMS and 111 POMS patients underwent neuropsychological testing (Brief Repeatable Battery, Stroop test), assessment of cognitive reserve (CR) (education, National Adult reading Test –NART, Barratt Simplified Measure of Social Status), fatigue (Fatigue Severity Scale), depression (Montgomery-Åsberg Depression Rating Scale), socio-professional performance (Work and Social Adjustment Scale -WSAS). Prognostic factors were assessed using logistic and linear multivariable regression analyses. Results: 34.5% of patients showed CI without significant differences between AOMS and POMS. Cognitively impaired patients were older (p=0.024), had higher EDSS scores (p=0.041) and lower IQ (p

KW - Adult onset multiple sclerosis

KW - Cognitive performances

KW - Cognitive reserve

KW - Pediatric onset multiple sclerosis

KW - Socio-professional outcomes

KW - adult

KW - Article

KW - Barratt Simplified Measure of Social Status

KW - Brief Repeatable Battery

KW - cognitive reserve

KW - comorbidity

KW - controlled study

KW - disease duration

KW - Expanded Disability Status Scale

KW - Fatigue Severity Scale

KW - female

KW - human

KW - intelligence quotient

KW - major clinical study

KW - male

KW - mental capacity

KW - mental performance

KW - Montgomery Asberg Depression Rating Scale

KW - multiple sclerosis

KW - national adult reading test

KW - neuropsychological test

KW - occupational health

KW - onset age

KW - social behavior

KW - Stroop test

U2 - 10.1016/j.msard.2020.102145

DO - 10.1016/j.msard.2020.102145

M3 - Article

VL - 42

JO - Mult. Scler. Relat. Disord.

JF - Mult. Scler. Relat. Disord.

SN - 2211-0348

ER -

Cognitive reserve is a determinant of social and occupational attainment in patients with pediatric and adult onset multiple sclerosis: Multiple Sclerosis and Related Disorders

Abstract

Keywords

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