Cognitive Stimulation Modulates Platelet Total Phospholipases A2 Activity in Subjects with Mild Cognitive Impairment

Research output: Contribution to journalArticle

Abstract

We evaluated the effect of cognitive stimulation (CS) on platelet total phospholipases A2 activity (tPLA2A) in patients with mild cognitive impairment (MCI-P). At baseline, tPLA2A negatively correlated with Mini-Mental State Examination score (MMSE-s): patients with MMSE-s 2A reduction, whereas Subgroup 2 did not significantly changes after training. Our results showed for the first time that tPLA2A correlates with the cognitive conditions of MCI-P, and that CS acts selectively on subjects with a dysregulated tPLA2A.

Original languageEnglish
Pages (from-to)957-962
Number of pages6
JournalJournal of Alzheimer's Disease
Volume50
Issue number4
DOIs
Publication statusPublished - Feb 22 2016

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Phospholipases A2
Blood Platelets
Cognitive Dysfunction

Keywords

  • Blood platelets
  • cognitive stimulation
  • mild cognitive impairment
  • phospholipases A2

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

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title = "Cognitive Stimulation Modulates Platelet Total Phospholipases A2 Activity in Subjects with Mild Cognitive Impairment",
abstract = "We evaluated the effect of cognitive stimulation (CS) on platelet total phospholipases A2 activity (tPLA2A) in patients with mild cognitive impairment (MCI-P). At baseline, tPLA2A negatively correlated with Mini-Mental State Examination score (MMSE-s): patients with MMSE-s 2A reduction, whereas Subgroup 2 did not significantly changes after training. Our results showed for the first time that tPLA2A correlates with the cognitive conditions of MCI-P, and that CS acts selectively on subjects with a dysregulated tPLA2A.",
keywords = "Blood platelets, cognitive stimulation, mild cognitive impairment, phospholipases A2",
author = "Marta Balietti and Cinzia Giuli and Patrizia Fattoretti and Paolo Fabbietti and Demetrio Postacchini and Fiorenzo Conti",
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AU - Balietti, Marta

AU - Giuli, Cinzia

AU - Fattoretti, Patrizia

AU - Fabbietti, Paolo

AU - Postacchini, Demetrio

AU - Conti, Fiorenzo

PY - 2016/2/22

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AB - We evaluated the effect of cognitive stimulation (CS) on platelet total phospholipases A2 activity (tPLA2A) in patients with mild cognitive impairment (MCI-P). At baseline, tPLA2A negatively correlated with Mini-Mental State Examination score (MMSE-s): patients with MMSE-s 2A reduction, whereas Subgroup 2 did not significantly changes after training. Our results showed for the first time that tPLA2A correlates with the cognitive conditions of MCI-P, and that CS acts selectively on subjects with a dysregulated tPLA2A.

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