Cognitive training in Alzheimer’s disease: a controlled randomized study

A. R. Giovagnoli, V. Manfredi, A. Parente, L. Schifano, S. Oliveri, G. Avanzini

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

This controlled randomized single-blind study evaluated the effects of cognitive training (CT), compared to active music therapy (AMT) and neuroeducation (NE), on initiative in patients with mild to moderate Alzheimer’s disease (AD). Secondarily, we explored the effects of CT on episodic memory, mood, and social relationships. Thirty-nine AD patients were randomly assigned to CT, AMT, or NE. Each treatment lasted 3 months. Before, at the end, and 3 months after treatment, neuropsychological tests and self-rated scales assessed initiative, episodic memory, depression, anxiety, and social relationships. At the end of the CT, initiative significantly improved, whereas, at the end of AMT and NE, it was unchanged. Episodic memory showed no changes at the end of CT or AMT and a worsening after NE. The rates of the patients with clinically significant improvement of initiative were greater after CT (about 62%) than after AMT (about 8%) or NE (none). At the 3-month follow-up, initiative and episodic memory declined in all patients. Mood and social relationships improved in the three groups, with greater changes after AMT or NE. In patients with mild to moderate AD, CT can improve initiative and stabilize memory, while the non-cognitive treatments can ameliorate the psychosocial aspects. The combining of CT and non-cognitive treatments may have useful clinical implications.

Original languageEnglish
Pages (from-to)1485-1493
Number of pages9
JournalNeurological Sciences
Volume38
Issue number8
DOIs
Publication statusPublished - Aug 1 2017

Fingerprint

Music Therapy
Alzheimer Disease
Episodic Memory
Single-Blind Method
Neuropsychological Tests
Therapeutics
Anxiety
Depression

Keywords

  • Alzheimer’s disease
  • Cognitive training
  • Initiative
  • Memory
  • Music therapy

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Cognitive training in Alzheimer’s disease : a controlled randomized study. / Giovagnoli, A. R.; Manfredi, V.; Parente, A.; Schifano, L.; Oliveri, S.; Avanzini, G.

In: Neurological Sciences, Vol. 38, No. 8, 01.08.2017, p. 1485-1493.

Research output: Contribution to journalArticle

Giovagnoli, A. R. ; Manfredi, V. ; Parente, A. ; Schifano, L. ; Oliveri, S. ; Avanzini, G. / Cognitive training in Alzheimer’s disease : a controlled randomized study. In: Neurological Sciences. 2017 ; Vol. 38, No. 8. pp. 1485-1493.
@article{8b47c4ba0e1e4fa086fe5cb202d09e35,
title = "Cognitive training in Alzheimer’s disease: a controlled randomized study",
abstract = "This controlled randomized single-blind study evaluated the effects of cognitive training (CT), compared to active music therapy (AMT) and neuroeducation (NE), on initiative in patients with mild to moderate Alzheimer’s disease (AD). Secondarily, we explored the effects of CT on episodic memory, mood, and social relationships. Thirty-nine AD patients were randomly assigned to CT, AMT, or NE. Each treatment lasted 3 months. Before, at the end, and 3 months after treatment, neuropsychological tests and self-rated scales assessed initiative, episodic memory, depression, anxiety, and social relationships. At the end of the CT, initiative significantly improved, whereas, at the end of AMT and NE, it was unchanged. Episodic memory showed no changes at the end of CT or AMT and a worsening after NE. The rates of the patients with clinically significant improvement of initiative were greater after CT (about 62{\%}) than after AMT (about 8{\%}) or NE (none). At the 3-month follow-up, initiative and episodic memory declined in all patients. Mood and social relationships improved in the three groups, with greater changes after AMT or NE. In patients with mild to moderate AD, CT can improve initiative and stabilize memory, while the non-cognitive treatments can ameliorate the psychosocial aspects. The combining of CT and non-cognitive treatments may have useful clinical implications.",
keywords = "Alzheimer’s disease, Cognitive training, Initiative, Memory, Music therapy",
author = "Giovagnoli, {A. R.} and V. Manfredi and A. Parente and L. Schifano and S. Oliveri and G. Avanzini",
year = "2017",
month = "8",
day = "1",
doi = "10.1007/s10072-017-3003-9",
language = "English",
volume = "38",
pages = "1485--1493",
journal = "Neurological Sciences",
issn = "1590-1874",
publisher = "Springer-Verlag Italia s.r.l.",
number = "8",

}

TY - JOUR

T1 - Cognitive training in Alzheimer’s disease

T2 - a controlled randomized study

AU - Giovagnoli, A. R.

AU - Manfredi, V.

AU - Parente, A.

AU - Schifano, L.

AU - Oliveri, S.

AU - Avanzini, G.

PY - 2017/8/1

Y1 - 2017/8/1

N2 - This controlled randomized single-blind study evaluated the effects of cognitive training (CT), compared to active music therapy (AMT) and neuroeducation (NE), on initiative in patients with mild to moderate Alzheimer’s disease (AD). Secondarily, we explored the effects of CT on episodic memory, mood, and social relationships. Thirty-nine AD patients were randomly assigned to CT, AMT, or NE. Each treatment lasted 3 months. Before, at the end, and 3 months after treatment, neuropsychological tests and self-rated scales assessed initiative, episodic memory, depression, anxiety, and social relationships. At the end of the CT, initiative significantly improved, whereas, at the end of AMT and NE, it was unchanged. Episodic memory showed no changes at the end of CT or AMT and a worsening after NE. The rates of the patients with clinically significant improvement of initiative were greater after CT (about 62%) than after AMT (about 8%) or NE (none). At the 3-month follow-up, initiative and episodic memory declined in all patients. Mood and social relationships improved in the three groups, with greater changes after AMT or NE. In patients with mild to moderate AD, CT can improve initiative and stabilize memory, while the non-cognitive treatments can ameliorate the psychosocial aspects. The combining of CT and non-cognitive treatments may have useful clinical implications.

AB - This controlled randomized single-blind study evaluated the effects of cognitive training (CT), compared to active music therapy (AMT) and neuroeducation (NE), on initiative in patients with mild to moderate Alzheimer’s disease (AD). Secondarily, we explored the effects of CT on episodic memory, mood, and social relationships. Thirty-nine AD patients were randomly assigned to CT, AMT, or NE. Each treatment lasted 3 months. Before, at the end, and 3 months after treatment, neuropsychological tests and self-rated scales assessed initiative, episodic memory, depression, anxiety, and social relationships. At the end of the CT, initiative significantly improved, whereas, at the end of AMT and NE, it was unchanged. Episodic memory showed no changes at the end of CT or AMT and a worsening after NE. The rates of the patients with clinically significant improvement of initiative were greater after CT (about 62%) than after AMT (about 8%) or NE (none). At the 3-month follow-up, initiative and episodic memory declined in all patients. Mood and social relationships improved in the three groups, with greater changes after AMT or NE. In patients with mild to moderate AD, CT can improve initiative and stabilize memory, while the non-cognitive treatments can ameliorate the psychosocial aspects. The combining of CT and non-cognitive treatments may have useful clinical implications.

KW - Alzheimer’s disease

KW - Cognitive training

KW - Initiative

KW - Memory

KW - Music therapy

UR - http://www.scopus.com/inward/record.url?scp=85020107194&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020107194&partnerID=8YFLogxK

U2 - 10.1007/s10072-017-3003-9

DO - 10.1007/s10072-017-3003-9

M3 - Article

AN - SCOPUS:85020107194

VL - 38

SP - 1485

EP - 1493

JO - Neurological Sciences

JF - Neurological Sciences

SN - 1590-1874

IS - 8

ER -