Cognitive training is ineffective in hypoxemic COPD: A six-month randomized controlled trial

Raffaele Antonelli Incalzi, Andrea Corsonello, Luigi Trojano, Claudio Pedone, Domenico Acanfora, Aldo Spada, Orsola Izzo, Franco Rengo

Research output: Contribution to journalArticle

Abstract

Cognitive impairment is highly prevalent in chronic obstructive pulmonary disease (COPD) complicated by chronic hypoxemia, but the effect of cognitive training in patients with COPD has not been studied. The aim of the present study was to verify whether cognitive training can preserve cognitive abilities of patients with hypoxemic COPD. Our series consisted of 105 COPD patients with at rest (n = 36) or effort (n = 69) hypoxemia and free from concurrent dementing diseases. Neuropsychologic assessment included a screening test, the Mini Mental State Examination (MMSE), and a standardized confirmatory battery of neuropsychological tests, the Mental Deterioration Battery (MDB). After baseline assessment, patients were randomized to receive standardized multidimensional care (standardization of pharmacological therapy, health education, selection of inhalers according to patient's ability, respiratory rehabilitation, nutritional counseling, oxygen therapy, and control visits) with (n = 53) or without (n = 52) cognitive training aimed at stimulating attention, learning, and logical-deductive thinking. Cognitive performance was reassessed after 1.5, 4, and 6 months. The analysis of variance for repeated measures (ANOVA) having the group membership (study vs. control) as grouping factor was used to assess changes in cognitive performance. Both intervention and control groups showed no significant changes in cognitive performance except for a trend toward improvement in verbal fluency and verbal memory, but cognitive intervention had no significant effect. In conclusion, cognitive training seems ineffective in COPD. However, a multidimensional standardized therapeutic approach, as it was indistinctly provided to all patients, could help to slow or prevent cognitive decline.

Original languageEnglish
Pages (from-to)239-250
Number of pages12
JournalRejuvenation Research
Volume11
Issue number1
DOIs
Publication statusPublished - Feb 1 2008

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Chronic Obstructive Pulmonary Disease
Randomized Controlled Trials
Aptitude
Analysis of Variance
Intelligence Tests
Neuropsychological Tests
Nebulizers and Vaporizers
Health Education
Counseling
Therapeutics
Rehabilitation
Learning
Pharmacology
Oxygen
Control Groups
Cognitive Dysfunction
Hypoxia

ASJC Scopus subject areas

  • Ageing

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Cognitive training is ineffective in hypoxemic COPD : A six-month randomized controlled trial. / Incalzi, Raffaele Antonelli; Corsonello, Andrea; Trojano, Luigi; Pedone, Claudio; Acanfora, Domenico; Spada, Aldo; Izzo, Orsola; Rengo, Franco.

In: Rejuvenation Research, Vol. 11, No. 1, 01.02.2008, p. 239-250.

Research output: Contribution to journalArticle

Incalzi, RA, Corsonello, A, Trojano, L, Pedone, C, Acanfora, D, Spada, A, Izzo, O & Rengo, F 2008, 'Cognitive training is ineffective in hypoxemic COPD: A six-month randomized controlled trial', Rejuvenation Research, vol. 11, no. 1, pp. 239-250. https://doi.org/10.1089/rej.2007.0607
Incalzi, Raffaele Antonelli ; Corsonello, Andrea ; Trojano, Luigi ; Pedone, Claudio ; Acanfora, Domenico ; Spada, Aldo ; Izzo, Orsola ; Rengo, Franco. / Cognitive training is ineffective in hypoxemic COPD : A six-month randomized controlled trial. In: Rejuvenation Research. 2008 ; Vol. 11, No. 1. pp. 239-250.
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