TY - JOUR
T1 - ANALISI DELLA COERENZA NELLA MALATTIA DI ALZHEIMER
AU - Comi, G.
AU - Locatelli, T.
AU - Cursi, M.
AU - Mauri, M.
AU - Elia, A.
AU - Liberati, D.
PY - 1994
Y1 - 1994
N2 - The analysis of EEG coherence allows to study coupling of bioelectrical activity of different cerebral areas and gives informations about inter and intra-hemispheric connections. EEG coherence, at rest, has been evaluated with an AutoRegressive parametric model in 10 patients affected by probable Alzheimer's Disease. Six patients presented a decreased alpha band coherence, more prounounced over temporo-parietal region in 3 patients and in frontal region in other 2 patients. In 2 out of these 6 patients, there was a significant increase of delta coherence, without phase shift, more pronounced over regions far from the examined electrode. These two changes are probably related to different pathophysiologic events: alpha coherence decrease is due to alterations of cortico-cortical connections while delta coherence increase is secondary to the involvement of cholinergic pathways projecting diffusely to cortical areas.
AB - The analysis of EEG coherence allows to study coupling of bioelectrical activity of different cerebral areas and gives informations about inter and intra-hemispheric connections. EEG coherence, at rest, has been evaluated with an AutoRegressive parametric model in 10 patients affected by probable Alzheimer's Disease. Six patients presented a decreased alpha band coherence, more prounounced over temporo-parietal region in 3 patients and in frontal region in other 2 patients. In 2 out of these 6 patients, there was a significant increase of delta coherence, without phase shift, more pronounced over regions far from the examined electrode. These two changes are probably related to different pathophysiologic events: alpha coherence decrease is due to alterations of cortico-cortical connections while delta coherence increase is secondary to the involvement of cholinergic pathways projecting diffusely to cortical areas.
KW - Alzheimer's disease
KW - coherence
KW - cortico-cortical connections
KW - dementia
KW - electroencephalography
UR - http://www.scopus.com/inward/record.url?scp=0028685263&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028685263&partnerID=8YFLogxK
M3 - Articolo
AN - SCOPUS:0028685263
VL - 40
SP - 505
EP - 508
JO - Rivista Italiana di Neurobiologia
JF - Rivista Italiana di Neurobiologia
SN - 0035-6336
IS - 5-6
ER -