Cohort study of association of risk of breast cancer with cyst type in women with gross cystic disease of the breast

Paolo Bruzzi, Luigi Dogliotti, Carlo Naldoni, Lauro Bucchi, Massimo Costantini, Alessandra Cicognani, Mirella Torta, Gian Franco Buzzi, Alberto Angeli

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Abstract

Objective: To assess correlation between type of breast cyst and risk of breast cancer in women with gross cystic disease of the breast. Design: Cohort study of women with breast cysts aspirated between 1983 and 1993 who were followed up until December 1994 for occurrence of breast cancer. Setting: Major cancer prevention centre. Subjects: 802 women with aspirated breast cysts. Main outcome measures: Type of breast cyst based on cationic content of cyst fluid: type I (potassium:sodium ratio > 1.5), type II (potassium:sodium ratio <1.5), or mixed (both types). Subsequent occurrence and type of breast cancer. Results: After median follow up of six years (range 2-12 years) 15 cases of invasive breast cancer and two ductal carcinomas in situ were diagnosed in the cohort: 12 invasive cancers (and two carcinomas in situ) among the 417 women with type I cysts, two cancers among the 325 women with type II cysts, and one among the 60 women with mixed cysts. The incidence of breast cancer in women with type I cysts was significantly higher than that in women with type II cysts (relative risk 4.62 (95% confidence interval 1.26 to 29.7)). These results were confirmed after adjustment for several risk factors for breast cancer (relative risk 4.24 (1.12 to 27.5)). Conclusions: The increased risk of breast cancer of women with breast cysts seems to be concentrated among women with type I breast cysts.

Original languageEnglish
Pages (from-to)925-928
Number of pages4
JournalBritish Medical Journal
Volume314
Issue number7085
Publication statusPublished - 1997

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Fibrocystic Breast Disease
Breast Cyst
Cysts
Cohort Studies
Breast Neoplasms
Potassium
Sodium
Cyst Fluid
Neoplasms
Carcinoma, Intraductal, Noninfiltrating
Carcinoma in Situ
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Medicine(all)

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Cohort study of association of risk of breast cancer with cyst type in women with gross cystic disease of the breast. / Bruzzi, Paolo; Dogliotti, Luigi; Naldoni, Carlo; Bucchi, Lauro; Costantini, Massimo; Cicognani, Alessandra; Torta, Mirella; Buzzi, Gian Franco; Angeli, Alberto.

In: British Medical Journal, Vol. 314, No. 7085, 1997, p. 925-928.

Research output: Contribution to journalArticle

Bruzzi, P, Dogliotti, L, Naldoni, C, Bucchi, L, Costantini, M, Cicognani, A, Torta, M, Buzzi, GF & Angeli, A 1997, 'Cohort study of association of risk of breast cancer with cyst type in women with gross cystic disease of the breast', British Medical Journal, vol. 314, no. 7085, pp. 925-928.
Bruzzi, Paolo ; Dogliotti, Luigi ; Naldoni, Carlo ; Bucchi, Lauro ; Costantini, Massimo ; Cicognani, Alessandra ; Torta, Mirella ; Buzzi, Gian Franco ; Angeli, Alberto. / Cohort study of association of risk of breast cancer with cyst type in women with gross cystic disease of the breast. In: British Medical Journal. 1997 ; Vol. 314, No. 7085. pp. 925-928.
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