Coincidence between fragile site expression and interstitial deletion of chromosome 11 in a case of myelofibrosis

M. Sessarego, F. Ajmar, R. Ravazzolo, G. L Bianchi Scarrà, C. Garrè, P. Boccaccio

Research output: Contribution to journalArticlepeer-review

Abstract

Cytogenetic examination of multiple peripheral blood cultures of a patient with myelofibrosis with myeloid metaplasia revealed the presence of an interstitial deletion of the long arm of chromosome 11, del(11)(q13q21). A folic acid dependent fragile site fra(11)(q13) was found in about 12% of the cells. The possible correlation between constitutional fragile site and acquired chromosomal alteration is discussed briefly.

Original languageEnglish
Pages (from-to)299-301
Number of pages3
JournalHuman Genetics
Volume63
Issue number3
DOIs
Publication statusPublished - May 1983

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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