Abstract
The view that the neocortex is remotely recruited for long-term episodic memory recall is challenged by data showing that an intense transcriptional and synaptic activity is detected in this region immediately after training. By measuring markers of synaptic activity at recent and remote time points from contextual fear conditioning (CFC), we could show that pre-synaptic changes are selectively detected 1 day post-training when the memory is anchored to the training context. Differently, pre- and post-synaptic changes are detected 14 days post-training when the memory generalizes to other contexts. Confirming that coincident pre- and post-synaptic remodelling mediates the disengagement of memory from its original context, DREADDs-mediated enhancement of cortical neuron activity during CFC training anticipates expression of a schematic memory and observation of bilateral synaptic remodelling. Together, our data show that the plastic properties of cortical synapses vary over time and specialise in relation to the quality of memory.
| Original language | English |
|---|---|
| Journal | Molecular Neurobiology |
| DOIs | |
| Publication status | Published - Jan 1 2019 |
Fingerprint
Keywords
- Dendritic spines
- DREADDs
- Episodic memory
- Miniature EPSC
- Neocortex
- Synaptic proteins
- Systems consolidation
ASJC Scopus subject areas
- Neuroscience (miscellaneous)
- Neurology
- Cellular and Molecular Neuroscience
Cite this
Coincident Pre- and Post-Synaptic Cortical Remodelling Disengages Episodic Memory from Its Original Context. / Vetere, Gisella; Borreca, Antonella; Pignataro, Annabella; Conforto, Giulia; Giustizieri, Michela; Marinelli, Silvia; Ammassari-Teule, Martine.
In: Molecular Neurobiology, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Coincident Pre- and Post-Synaptic Cortical Remodelling Disengages Episodic Memory from Its Original Context
AU - Vetere, Gisella
AU - Borreca, Antonella
AU - Pignataro, Annabella
AU - Conforto, Giulia
AU - Giustizieri, Michela
AU - Marinelli, Silvia
AU - Ammassari-Teule, Martine
PY - 2019/1/1
Y1 - 2019/1/1
N2 - The view that the neocortex is remotely recruited for long-term episodic memory recall is challenged by data showing that an intense transcriptional and synaptic activity is detected in this region immediately after training. By measuring markers of synaptic activity at recent and remote time points from contextual fear conditioning (CFC), we could show that pre-synaptic changes are selectively detected 1 day post-training when the memory is anchored to the training context. Differently, pre- and post-synaptic changes are detected 14 days post-training when the memory generalizes to other contexts. Confirming that coincident pre- and post-synaptic remodelling mediates the disengagement of memory from its original context, DREADDs-mediated enhancement of cortical neuron activity during CFC training anticipates expression of a schematic memory and observation of bilateral synaptic remodelling. Together, our data show that the plastic properties of cortical synapses vary over time and specialise in relation to the quality of memory.
AB - The view that the neocortex is remotely recruited for long-term episodic memory recall is challenged by data showing that an intense transcriptional and synaptic activity is detected in this region immediately after training. By measuring markers of synaptic activity at recent and remote time points from contextual fear conditioning (CFC), we could show that pre-synaptic changes are selectively detected 1 day post-training when the memory is anchored to the training context. Differently, pre- and post-synaptic changes are detected 14 days post-training when the memory generalizes to other contexts. Confirming that coincident pre- and post-synaptic remodelling mediates the disengagement of memory from its original context, DREADDs-mediated enhancement of cortical neuron activity during CFC training anticipates expression of a schematic memory and observation of bilateral synaptic remodelling. Together, our data show that the plastic properties of cortical synapses vary over time and specialise in relation to the quality of memory.
KW - Dendritic spines
KW - DREADDs
KW - Episodic memory
KW - Miniature EPSC
KW - Neocortex
KW - Synaptic proteins
KW - Systems consolidation
UR - http://www.scopus.com/inward/record.url?scp=85068790527&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85068790527&partnerID=8YFLogxK
U2 - 10.1007/s12035-019-01652-3
DO - 10.1007/s12035-019-01652-3
M3 - Article
AN - SCOPUS:85068790527
JO - Molecular Neurobiology
JF - Molecular Neurobiology
SN - 0893-7648
ER -