Cold haemagglutinin disease with severe anaemia, reticulocytopenia and erythroid bone marrow

M. Cazzola, G. Barosi, E. Ascari

Research output: Contribution to journalArticlepeer-review

Abstract

A quantitative assessment of total, effective and ineffective erythropoiesis, and mean red cell life-span was performed in 2 patients with idiopathic cold-haemagglutinin disease (CHAD) who had severe anaemia, reticulocytopenia and erythroid bone marrow. In both cases, ineffective erythropoiesis represented the major factor in the pathogenesis of the anaemia. The most likely explanation of this was that cold antibodies had some effect on the maturing red-cell precursors. Ineffective erythropoiesis has already been shown in patients affected by autoimmune haemolytic anaemia due to warm antibodies with reticulocytopenia and erythroid bone marrow. Therefore, it is apparent that both warm and cold antibodies may cause not only peripheral destruction of mature red cells but also intramedullary death of red cell precursors.

Original languageEnglish
Pages (from-to)25-29
Number of pages5
JournalScandinavian Journal of Haematology
Volume30
Issue number1
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Cold haemagglutinin disease with severe anaemia, reticulocytopenia and erythroid bone marrow'. Together they form a unique fingerprint.

Cite this