Colistin enhances therapeutic efficacy of daptomycin or teicoplanin in a murine model of multiresistant Acinetobacter baumannii sepsis

Oscar Cirioni, Oriana Simonetti, Elisa Pierpaoli, Alessandra Barucca, Roberto Ghiselli, Fiorenza Orlando, Maria Pelloni, Maria Michela Cappelletti Trombettoni, Mario Guerrieri, Annamaria Offidani, Andrea Giacometti, Mauro Provinciali

Research output: Contribution to journalArticle

Abstract

We investigated the efficacy of colistin combined with teicoplanin or daptomycin in an experimental mouse model of multiresistant Acinetobacter baumannii infection. Animal received intraperitoneally 1 ml saline containing 2 × 1010 CFU of A. baumannii. Colistin, daptomycin, teicoplanin, and colistin plus daptomycin or teicoplanin were given by intraperitoneal administration 2 h after bacterial challenge. A control group received sodium chloride solution. In the in vitro study A. baumannii showed to be susceptible only to colistin with MIC of 2 mg/l. In the in vivo study, colistin alone showed a good antimicrobial efficacy. When combined with teicoplanin or daptomycin, colistin produced the lowest bacterial and the best survival rates. In immunological studies, when colistin was associated to daptomycin or teicoplanin, both the number and the cytotoxic activity of NK cells increased. In conclusion, colistin combined with teicoplanin or daptomycin may improve the therapy of multiresistant A. baumannii infection.

Original languageEnglish
Pages (from-to)392-398
Number of pages7
JournalDiagnostic Microbiology and Infectious Disease
Volume86
Issue number4
DOIs
Publication statusPublished - Dec 1 2016

Keywords

  • A. baumannii
  • Animal model
  • Multiresistant organisms
  • Sepsis
  • Synergy

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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