Colistin in combination with rifampin and imipenem for treating a blaVIM-1 metallo-β-lactamase-producing Enterobacter cloacae disseminated infection in a liver transplant patient

C. Tascini, L. Urbani, G. Biancofiore, G. M. Rossolini, A. Leonildi, G. Gemignani, M. L. Bindi, C. Mugnaioli, F. Filipponi, F. Menichetti

Research output: Contribution to journalArticle

Abstract

A case of blavVIM-1 producing E. cloacae disseminated infection in a patient submitted to orthotopic liver transplantation is described. Synergism between colistin, rifampin and imipenem was studied in vitro and this combination of three drugs was used to treat E. cloacae infection. The synergistic activity of this combination was demonstrated showing an increased activity of the serum bactericidal activity in comparison with the bactericidal activity of the serum taken during the previous therapy.

Original languageEnglish
Pages (from-to)47-49
Number of pages3
JournalMinerva Anestesiologica
Volume74
Issue number1-2
Publication statusPublished - Jan 2008

Keywords

  • Anti-bacterial agents
  • Colistin
  • Imipenem
  • Liver transplantation
  • Rifampin

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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    Tascini, C., Urbani, L., Biancofiore, G., Rossolini, G. M., Leonildi, A., Gemignani, G., Bindi, M. L., Mugnaioli, C., Filipponi, F., & Menichetti, F. (2008). Colistin in combination with rifampin and imipenem for treating a blaVIM-1 metallo-β-lactamase-producing Enterobacter cloacae disseminated infection in a liver transplant patient. Minerva Anestesiologica, 74(1-2), 47-49.