Abstract
Purpose: To investigate the effects of titanium implants functionalised with collagen type I (TiColl) on bone regeneration and osteointegration in a healthy and osteopenic rat animal model. Method: TiColl screws were implanted into the femoral condyles of healthy and osteopenic rats and compared with acid-etched titanium (Ti) screws. The osteointegration process was evaluated by a complementary approach combining microtomographic, histological, histomorphometric and biomechanical investigations at four and 12 weeks. Results: The TiColl screw also ensured a greater mechanical stability; the push-out values for TiColl screws increased from four to 12 weeks (+28 %). The energy necessary to detach the bone from the screw was significantly higher for TiColl-functionalised screws in comparison to Ti screws (+23 %) at 12 weeks. Histomorphometric investigation revealed that total bone-to-implant contact was higher in TiColl screws in comparison to Ti screws (P <0.05) and at epiphyseal level, increased bone-to-implant contact was found with TiColl screws in comparison to Ti screws (P <0.05) in an ovariectomy (OVX) condition. A significant increase in the measured total bone ingrowth from four to 12 weeks was detected for both materials, but more significant for the TiColl material (P <0.0005). Finally, bone ingrowth in the TiColl group was significantly higher (P <0.005) in comparison to that of Ti screws in the SHAM condition at metaphyseal level at 12 weeks. Conclusion: The present results showed that TiColl is effective in promoting implant osteointegration even in compromised bone.
| Original language | English |
|---|---|
| Pages (from-to) | 2041-2052 |
| Number of pages | 12 |
| Journal | International Orthopaedics |
| Volume | 39 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Jul 25 2015 |
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Keywords
- Collagen type I
- Implants
- Osteointegration
- Osteopenic condition
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
Cite this
Collagen type I coating stimulates bone regeneration and osteointegration of titanium implants in the osteopenic rat. / Sartori, Maria; Giavaresi, Gianluca; Parrilli, Annapaola; Ferrari, Andrea; Aldini, Nicolò Nicoli; Morra, Marco; Cassinelli, Clara; Bollati, Daniele; Fini, Milena.
In: International Orthopaedics, Vol. 39, No. 10, 25.07.2015, p. 2041-2052.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Collagen type I coating stimulates bone regeneration and osteointegration of titanium implants in the osteopenic rat
AU - Sartori, Maria
AU - Giavaresi, Gianluca
AU - Parrilli, Annapaola
AU - Ferrari, Andrea
AU - Aldini, Nicolò Nicoli
AU - Morra, Marco
AU - Cassinelli, Clara
AU - Bollati, Daniele
AU - Fini, Milena
PY - 2015/7/25
Y1 - 2015/7/25
N2 - Purpose: To investigate the effects of titanium implants functionalised with collagen type I (TiColl) on bone regeneration and osteointegration in a healthy and osteopenic rat animal model. Method: TiColl screws were implanted into the femoral condyles of healthy and osteopenic rats and compared with acid-etched titanium (Ti) screws. The osteointegration process was evaluated by a complementary approach combining microtomographic, histological, histomorphometric and biomechanical investigations at four and 12 weeks. Results: The TiColl screw also ensured a greater mechanical stability; the push-out values for TiColl screws increased from four to 12 weeks (+28 %). The energy necessary to detach the bone from the screw was significantly higher for TiColl-functionalised screws in comparison to Ti screws (+23 %) at 12 weeks. Histomorphometric investigation revealed that total bone-to-implant contact was higher in TiColl screws in comparison to Ti screws (P <0.05) and at epiphyseal level, increased bone-to-implant contact was found with TiColl screws in comparison to Ti screws (P <0.05) in an ovariectomy (OVX) condition. A significant increase in the measured total bone ingrowth from four to 12 weeks was detected for both materials, but more significant for the TiColl material (P <0.0005). Finally, bone ingrowth in the TiColl group was significantly higher (P <0.005) in comparison to that of Ti screws in the SHAM condition at metaphyseal level at 12 weeks. Conclusion: The present results showed that TiColl is effective in promoting implant osteointegration even in compromised bone.
AB - Purpose: To investigate the effects of titanium implants functionalised with collagen type I (TiColl) on bone regeneration and osteointegration in a healthy and osteopenic rat animal model. Method: TiColl screws were implanted into the femoral condyles of healthy and osteopenic rats and compared with acid-etched titanium (Ti) screws. The osteointegration process was evaluated by a complementary approach combining microtomographic, histological, histomorphometric and biomechanical investigations at four and 12 weeks. Results: The TiColl screw also ensured a greater mechanical stability; the push-out values for TiColl screws increased from four to 12 weeks (+28 %). The energy necessary to detach the bone from the screw was significantly higher for TiColl-functionalised screws in comparison to Ti screws (+23 %) at 12 weeks. Histomorphometric investigation revealed that total bone-to-implant contact was higher in TiColl screws in comparison to Ti screws (P <0.05) and at epiphyseal level, increased bone-to-implant contact was found with TiColl screws in comparison to Ti screws (P <0.05) in an ovariectomy (OVX) condition. A significant increase in the measured total bone ingrowth from four to 12 weeks was detected for both materials, but more significant for the TiColl material (P <0.0005). Finally, bone ingrowth in the TiColl group was significantly higher (P <0.005) in comparison to that of Ti screws in the SHAM condition at metaphyseal level at 12 weeks. Conclusion: The present results showed that TiColl is effective in promoting implant osteointegration even in compromised bone.
KW - Collagen type I
KW - Implants
KW - Osteointegration
KW - Osteopenic condition
UR - http://www.scopus.com/inward/record.url?scp=84942295890&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84942295890&partnerID=8YFLogxK
U2 - 10.1007/s00264-015-2926-0
DO - 10.1007/s00264-015-2926-0
M3 - Article
C2 - 26206261
AN - SCOPUS:84942295890
VL - 39
SP - 2041
EP - 2052
JO - International Orthopaedics
JF - International Orthopaedics
SN - 0341-2695
IS - 10
ER -