Collagenase Clostridium histolyticum: emerging practice patterns and treatment advances

David Warwick, José M. Arandes-Renú, Giorgio Pajardi, Jörg Witthaut, Lawrence C. Hurst

Research output: Contribution to journalArticlepeer-review


Objective: This study aims to provide a comprehensive review of the role of Collagenase Clostridium histolyticum (CCH). Methods: This review is based on a literature review and practical experience. Results: This review provides practical management strategies for using collagenase by sharing clinical experiences over the past few years; logistical aspects of in-clinic treatment, lessons learned, and novel approaches to correct traditionally hard-to-treat contractures are discussed. In addition a brief, yet comprehensive overview is provided on the pathophysiology of the disease, the mechanism of collagenase action and results of clinical studies. Conclusion: CCH has an evolving role as one of the tools available for treating Dupuytren's disease.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalJournal of Plastic Surgery and Hand Surgery
Publication statusAccepted/In press - Mar 31 2016


  • clinical practice
  • clinical trial
  • Clostridium histolyticum
  • collagenase
  • dupuytren’s disease
  • xiaflex
  • xiapex

ASJC Scopus subject areas

  • Surgery


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