The resistance of the colonic mucosa to gastric or duodeno-gastric secretions has been evaluated in 120 Wistar rats bY transposing colonic segments to the gastric body or the duodeno-gastric junction. Vagotomy and pyloroplasty have been carried out in half of the animals. The specimens have been removed 4, 8 and 12 months after implantation and examined by light and electron microscopy. The transposed colonic mucosa underwent an adaptation procesS, consisting of: a. enhanced mucus production, b. shifting of mucin secretion patterns (increased amounts of sialomucins and decreased amounts of sulfomucins) and c. gastric-like transformation of the superficial epithelial cells. No damage of the colonic segments has been demonstrated, except for the alteration of the microvili. The greater damage potentiality of combining gastric and duodenal secretions, as well as the protective effects of vagotomy have been shown.
|Translated title of the contribution||Colonic segments as esophageal substitutes in the treatment of reflux stenosis. Long-term effects of the resistance to gastric and gastr-duodenal secretions|
|Number of pages||5|
|Publication status||Published - 1990|
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