Color Doppler imaging of liver metastases. The value phase-III of a US contrast agent: SH U 508 A (Levovist®) Schering

R. Campani, A. Bozzini, F. Calliada, O. Bottinelli, R. Anguissola, M. P. Conti, G. Corsi

Research output: Contribution to journalArticlepeer-review


In a phase-III multicenter clinical trial, the color Doppler vascular patterns were studied of 34 liver metastases in 18 patients before and after the i.v. injection of SH U 508 A (Levovist®), with different US units and probes. The patients were selected as having poor color Doppler signals at unenhanced examinations. Lesion size ranged .8 to 9 cm (mean: 3.5 cm). The primary lesion site was the colon in 14 cases, the breast in 8 cases, the lung in 4, the stomach in 4 cases, the ovary in 3 and finally unknown in 4 cases. Each patient received two to four contrast agent injections, with suggested doses and concentrations (10 ml x 300 mg/ml, 8 ml x 400 mgr/ml). No adverse reactions were observed. Thirteen of 34 lesions exhibited no vascular signals at baseline examinations, 10 exhibited some perilesional color spots or small vessel branches, 5 some internal color spots or vessels and 4 small internal and peripheral vessels. After contrast agent infusion, the vascular patterns were better demonstrated in 28/34 lesions and the signal-to-noise ratio was markedly improved, in a concentration-dependent manner, from 40 to 240 s. Five lesions remained avascular, 11 exhibited 'basket'-like vascular patterns, 10 'internal flow' patterns and finally 10 lesions exhibited both. No major correlation was observed between vascular pattern and lesion size. To conclude, the use of the intravenous contrast agent SH U 508 A (Levovist®) appears to be a promising technique to improve the color Doppler demonstration of focal metastatic liver lesions. Nonetheless, further studies on larger series of cases are needed to differentiate the different primary sites of the metastases.

Original languageEnglish
Pages (from-to)32-40
Number of pages9
JournalRadiologia Medica
Issue number5 SUPPL. 1
Publication statusPublished - 1994


  • color Doppler US, SH U 508 A (Levovist®), Schering
  • liver metastases, color Doppler US
  • liver, metastases

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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