TY - JOUR
T1 - Color Doppler quantitative measures to predict outcome of biopsies in prostate cancer
AU - Strigari, Lidia
AU - Marsella, Annelisa
AU - Canitano, Stefano
AU - Gomellini, Sara
AU - Arcangeli, Stefano
AU - Genovese, Elisabetta
AU - Saracino, Biancamaria
AU - Petrongari, Maria Grazia
AU - Sentinelli, Steno
AU - Crecco, Marcello
AU - Benassi, Marcello
AU - Arcangeli, Giorgio
PY - 2008
Y1 - 2008
N2 - Purpose: The aim was to correlate the color Doppler flow activity pre- and postradiotherapy, using transrectal color Doppler ultrasonography (CDUS) and the 2 year positive biopsy rate after radiotherapy in patients with prostate cancer. Methods and materials: Analysis was carried out in 69 out of 160 patients who had undergone treatment with 3D-conformal radiotherapy (3D-CRT) to prostate and seminal vesicles. Patients were randomized to receive 80 Gy in 40 fractions in 8 weeks (arm A) and 62 Gy in 20 fractions in 5 weeks, 4 fractions per week (arm B). Color Doppler flow activity (CDFA) was evaluated calculating the vascularization index (VI), defined as the ratio between the colored and total pixels in the whole and peripheral prostate, delineated by a radiation oncologist on CDUS images, using EcoVasc a home-made software. The difference between the 2 year post- and pre-3D-CRT maximum VI (VImax), named Δ VImax, was calculated in the whole and peripheral prostate for each patient. Then, Δ VImax and the detected 2 year biopsy outcome were analyzed using the receiver operating characteristics (ROC) technique. Results: The VImax increased or decreased in patients with positive or negative biopsies, respectively, compared to the value before RT in both arms. The area under the ROC curve for Δ VImax in the whole and peripheral prostate is equal to 0.790 and 0.884, respectively. Conclusion: The Δ VImax index, comparing CDFA at 2 years compared to that before RT, allows the 2 year postradiotherapy positive biopsy rate to be predicted.
AB - Purpose: The aim was to correlate the color Doppler flow activity pre- and postradiotherapy, using transrectal color Doppler ultrasonography (CDUS) and the 2 year positive biopsy rate after radiotherapy in patients with prostate cancer. Methods and materials: Analysis was carried out in 69 out of 160 patients who had undergone treatment with 3D-conformal radiotherapy (3D-CRT) to prostate and seminal vesicles. Patients were randomized to receive 80 Gy in 40 fractions in 8 weeks (arm A) and 62 Gy in 20 fractions in 5 weeks, 4 fractions per week (arm B). Color Doppler flow activity (CDFA) was evaluated calculating the vascularization index (VI), defined as the ratio between the colored and total pixels in the whole and peripheral prostate, delineated by a radiation oncologist on CDUS images, using EcoVasc a home-made software. The difference between the 2 year post- and pre-3D-CRT maximum VI (VImax), named Δ VImax, was calculated in the whole and peripheral prostate for each patient. Then, Δ VImax and the detected 2 year biopsy outcome were analyzed using the receiver operating characteristics (ROC) technique. Results: The VImax increased or decreased in patients with positive or negative biopsies, respectively, compared to the value before RT in both arms. The area under the ROC curve for Δ VImax in the whole and peripheral prostate is equal to 0.790 and 0.884, respectively. Conclusion: The Δ VImax index, comparing CDFA at 2 years compared to that before RT, allows the 2 year postradiotherapy positive biopsy rate to be predicted.
KW - Biopsies
KW - Color Doppler ultrasonography
KW - Hypo-fractionated radiotherapy
KW - Prostate cancer
KW - Vascularization index
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U2 - 10.1118/1.2990778
DO - 10.1118/1.2990778
M3 - Article
C2 - 19070211
AN - SCOPUS:54949108276
VL - 35
SP - 4793
EP - 4799
JO - Medical Physics
JF - Medical Physics
SN - 0094-2405
IS - 11
ER -