Colorectal cancer and 18FDG-PET/CT

What about adding the T to the N parameter in loco-regional staging?

Pier Paolo Mainenti, Delfina Iodice, Sabrina Segreto, Giovanni Storto, Mario Magliulo, Giovanni D. De Palma, Marco Salvatore, Leonardo Pace

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

AIM: To evaluate whether FDG-positron emission tomography (PET)/computed tomography (CT) may be an accurate technique in the assessment of the T stage in patients with colorectal cancer. METHODS: Thirty four consecutive patients (20 men and 14 women; mean age: 63 years) with a histologically proven diagnosis of colorectal adenocarcinoma and scheduled for surgery in our hospital were enrolled in this study. All patients underwent FDG-PET/CT preoperatively. The primary tumor site and extent were evaluated on PET/CT images. Colorectal wall invasion was analysed according to a modified T classification that considers only three stages (≤ T2, T3, T4). Assessment of accuracy was carried out using 95% confidence intervals for T. RESULTS: Thirty five/37 (94.6%) adenocarcinomas were identified and correctly located on PET/CT images. PET/CT correctly staged the T of 33/35 lesions identified showing an accuracy of 94.3% (95% CI: 87%-100%). All T1, T3 and T4 lesions were correctly staged, while two T2 neoplasms were overstated as T3. CONCLUSION: Our data suggest that FDG-PET/CT may be an accurate modality for identifying primary tumor and defining its local extent in patients with colorectal cancer.

Original languageEnglish
Pages (from-to)1427-1433
Number of pages7
JournalWorld Journal of Gastroenterology
Volume17
Issue number11
DOIs
Publication statusPublished - Mar 21 2011

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Fluorodeoxyglucose F18
Colorectal Neoplasms
Adenocarcinoma
Neoplasms
Positron Emission Tomography Computed Tomography
Confidence Intervals

Keywords

  • Cancer
  • Colorectal
  • Positron emission tomography/computed tomography
  • Staging

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Colorectal cancer and 18FDG-PET/CT : What about adding the T to the N parameter in loco-regional staging? / Mainenti, Pier Paolo; Iodice, Delfina; Segreto, Sabrina; Storto, Giovanni; Magliulo, Mario; De Palma, Giovanni D.; Salvatore, Marco; Pace, Leonardo.

In: World Journal of Gastroenterology, Vol. 17, No. 11, 21.03.2011, p. 1427-1433.

Research output: Contribution to journalArticle

Mainenti, Pier Paolo ; Iodice, Delfina ; Segreto, Sabrina ; Storto, Giovanni ; Magliulo, Mario ; De Palma, Giovanni D. ; Salvatore, Marco ; Pace, Leonardo. / Colorectal cancer and 18FDG-PET/CT : What about adding the T to the N parameter in loco-regional staging?. In: World Journal of Gastroenterology. 2011 ; Vol. 17, No. 11. pp. 1427-1433.
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abstract = "AIM: To evaluate whether FDG-positron emission tomography (PET)/computed tomography (CT) may be an accurate technique in the assessment of the T stage in patients with colorectal cancer. METHODS: Thirty four consecutive patients (20 men and 14 women; mean age: 63 years) with a histologically proven diagnosis of colorectal adenocarcinoma and scheduled for surgery in our hospital were enrolled in this study. All patients underwent FDG-PET/CT preoperatively. The primary tumor site and extent were evaluated on PET/CT images. Colorectal wall invasion was analysed according to a modified T classification that considers only three stages (≤ T2, T3, T4). Assessment of accuracy was carried out using 95{\%} confidence intervals for T. RESULTS: Thirty five/37 (94.6{\%}) adenocarcinomas were identified and correctly located on PET/CT images. PET/CT correctly staged the T of 33/35 lesions identified showing an accuracy of 94.3{\%} (95{\%} CI: 87{\%}-100{\%}). All T1, T3 and T4 lesions were correctly staged, while two T2 neoplasms were overstated as T3. CONCLUSION: Our data suggest that FDG-PET/CT may be an accurate modality for identifying primary tumor and defining its local extent in patients with colorectal cancer.",
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