Abstract
Colorectal carcinogenesis is a multistep process with an apparently orderly progression from benign tissue to invasive malignancy and metastases. Yet at the genome level, a considerably more chaotic situation exists, with order arising through the process of natural selection in the midst of genomic instability. Major pathways for colorectal carcinogenesis begin with suppressor loss or acquisition of a mutator phenotype, but there are other pathways known and yet to be described. These pathways result in the natural selection of cells with unstable genomes leading to malignancy and metastases.
| Original language | English |
|---|---|
| Pages (from-to) | 643-652 |
| Number of pages | 10 |
| Journal | Surgical Oncology Clinics of North America |
| Volume | 9 |
| Issue number | 4 |
| Publication status | Published - 2000 |
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ASJC Scopus subject areas
- Oncology
- Surgery
Cite this
Colorectal cancer : How does it start? How does it metastasize? / Rodriguez-Bigas, M. A.; Stoler, D. L.; Bertario, L.; Anderson, G. R.; Baba, S.
In: Surgical Oncology Clinics of North America, Vol. 9, No. 4, 2000, p. 643-652.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Colorectal cancer
T2 - How does it start? How does it metastasize?
AU - Rodriguez-Bigas, M. A.
AU - Stoler, D. L.
AU - Bertario, L.
AU - Anderson, G. R.
AU - Baba, S.
PY - 2000
Y1 - 2000
N2 - Colorectal carcinogenesis is a multistep process with an apparently orderly progression from benign tissue to invasive malignancy and metastases. Yet at the genome level, a considerably more chaotic situation exists, with order arising through the process of natural selection in the midst of genomic instability. Major pathways for colorectal carcinogenesis begin with suppressor loss or acquisition of a mutator phenotype, but there are other pathways known and yet to be described. These pathways result in the natural selection of cells with unstable genomes leading to malignancy and metastases.
AB - Colorectal carcinogenesis is a multistep process with an apparently orderly progression from benign tissue to invasive malignancy and metastases. Yet at the genome level, a considerably more chaotic situation exists, with order arising through the process of natural selection in the midst of genomic instability. Major pathways for colorectal carcinogenesis begin with suppressor loss or acquisition of a mutator phenotype, but there are other pathways known and yet to be described. These pathways result in the natural selection of cells with unstable genomes leading to malignancy and metastases.
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UR - http://www.scopus.com/inward/citedby.url?scp=0033809169&partnerID=8YFLogxK
M3 - Article
VL - 9
SP - 643
EP - 652
JO - Surgical Oncology Clinics of North America
JF - Surgical Oncology Clinics of North America
SN - 1055-3207
IS - 4
ER -