Colorectal cancer: How does it start? How does it metastasize?

M. A. Rodriguez-Bigas, D. L. Stoler, L. Bertario, G. R. Anderson, S. Baba

Research output: Contribution to journalArticlepeer-review


Colorectal carcinogenesis is a multistep process with an apparently orderly progression from benign tissue to invasive malignancy and metastases. Yet at the genome level, a considerably more chaotic situation exists, with order arising through the process of natural selection in the midst of genomic instability. Major pathways for colorectal carcinogenesis begin with suppressor loss or acquisition of a mutator phenotype, but there are other pathways known and yet to be described. These pathways result in the natural selection of cells with unstable genomes leading to malignancy and metastases.

Original languageEnglish
Pages (from-to)643-652
Number of pages10
JournalSurgical Oncology Clinics of North America
Issue number4
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Oncology
  • Surgery


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