Colorectal cancer

How does it start? How does it metastasize?

M. A. Rodriguez-Bigas, D. L. Stoler, L. Bertario, G. R. Anderson, S. Baba

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Colorectal carcinogenesis is a multistep process with an apparently orderly progression from benign tissue to invasive malignancy and metastases. Yet at the genome level, a considerably more chaotic situation exists, with order arising through the process of natural selection in the midst of genomic instability. Major pathways for colorectal carcinogenesis begin with suppressor loss or acquisition of a mutator phenotype, but there are other pathways known and yet to be described. These pathways result in the natural selection of cells with unstable genomes leading to malignancy and metastases.

Original languageEnglish
Pages (from-to)643-652
Number of pages10
JournalSurgical Oncology Clinics of North America
Volume9
Issue number4
Publication statusPublished - 2000

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Genetic Selection
Colorectal Neoplasms
Carcinogenesis
Genome
Neoplasm Metastasis
Genomic Instability
Neoplasms
Phenotype

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

Rodriguez-Bigas, M. A., Stoler, D. L., Bertario, L., Anderson, G. R., & Baba, S. (2000). Colorectal cancer: How does it start? How does it metastasize? Surgical Oncology Clinics of North America, 9(4), 643-652.

Colorectal cancer : How does it start? How does it metastasize? / Rodriguez-Bigas, M. A.; Stoler, D. L.; Bertario, L.; Anderson, G. R.; Baba, S.

In: Surgical Oncology Clinics of North America, Vol. 9, No. 4, 2000, p. 643-652.

Research output: Contribution to journalArticle

Rodriguez-Bigas, MA, Stoler, DL, Bertario, L, Anderson, GR & Baba, S 2000, 'Colorectal cancer: How does it start? How does it metastasize?', Surgical Oncology Clinics of North America, vol. 9, no. 4, pp. 643-652.
Rodriguez-Bigas MA, Stoler DL, Bertario L, Anderson GR, Baba S. Colorectal cancer: How does it start? How does it metastasize? Surgical Oncology Clinics of North America. 2000;9(4):643-652.
Rodriguez-Bigas, M. A. ; Stoler, D. L. ; Bertario, L. ; Anderson, G. R. ; Baba, S. / Colorectal cancer : How does it start? How does it metastasize?. In: Surgical Oncology Clinics of North America. 2000 ; Vol. 9, No. 4. pp. 643-652.
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