Colorectal cancer metastatic phenotype stimulates production by fibroblasts of N-terminal peptide of type III collagen: Clinical implications for prognosis

Daniela Basso, Claudio Belluco, Saverio Mazza, Eliana Greco, Fosca Della Rocca, Paolo Pauletto, Donato Nitti, Mario Lise, Mario Plebani

Research output: Contribution to journalArticlepeer-review

Abstract

In this study we assessed whether the serum levels of the N-terminal peptide of type III collagen (PIIIP), an index of type III collagen synthesis, are influenced by colorectal cancer stage, and whether "in vitro" fibroblast growth and PIIIP production could be altered by tumor tissues obtained from metastatic and nonmetastatic colorectal cancer. 208 colorectal cancer patients (115 colon and 93 rectum) were studied; 54 were stage I, 62 stage II, 37 stage III and 55 stage IV. PIIIP serum levels were significantly higher in stage IV as compared to all other patient groups. The 5-year survival of stage I, stage II, stage III and stage IV patients were 87%, 88%, 32% and 20%, respectively. In the subgroup of stage I and stage II patients considered together, PIIIP (>0.5 U/ml), but not CEA (>5 μg/l) serum levels, were predictive for survival. Fibroblast growth was significantly inhibited, while PIIIP production was significantly enhanced, when these cells were conditioned with colorectal cancer homogenates obtained from patients with distant metastases, than from those without distant metastases. In conclusion, colorectal tumors, when metastatic, stimulate fibroblasts' PIIIP synthesis and the serum levels of this peptide might predict patients' outcome after radical surgery.

Original languageEnglish
Pages (from-to)135-142
Number of pages8
JournalClinica Chimica Acta
Volume312
Issue number1-2
DOIs
Publication statusPublished - 2001

Keywords

  • CEA
  • Colorectal cancer
  • Fibroblasts
  • Prognosis
  • Type III collagen

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

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