Colorectal cancer microenvironment: Among nutrition, gut microbiota, inflammation and epigenetics

Paolo Garagnani, Chiara Pirazzini, Claudio Franceschi

Research output: Contribution to journalArticlepeer-review

Abstract

Colorectal cancer (CRC) is a major health problem causing significant morbidity and mortality. During the last decade, results from different studies indicate that the pathogenetic mechanisms of CRC encompass tumour microenvironment, emphasizing a tight correlation with aging, inflammation, nutrition, gut microbiome composition and epigenetic modifications. Aging is one of the most important risk factors for the development of a wide range of neoplasies, including CRC, as it represents the general framework in which the tumor environment evolves. Together, these elements likely contribute to the carcinogenic process with specific effects, impacts and roles in the different stages of the tumor progression. CRCs evolve through loops of deregulated inflammatory stimuli which are sustained by DNA damage signaling pathways, dysbiosis of gut microbiota (GM) and epigenetic re-modelling (DNA methylation). To date no studies address those elements simultaneously. The synergic analysis of such parameters could provide new biological insights and effective biomarkers that could have applications in prevention, molecular diagnosis, prognosis and treatment of CRC.

Original languageEnglish
Pages (from-to)765-778
Number of pages14
JournalCurrent Pharmaceutical Design
Volume19
Issue number4
Publication statusPublished - 2013

Keywords

  • Aging
  • Colorectal cancer
  • Epigenetic
  • Gut microbiota
  • Inflammation
  • Nutrition

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

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