Colorectal cancer treatment in elderly patients: Results of a retrospective analysis addressed to the chiefs of medical oncology units in Italy

Lara Maria Pasetto, Cristina Falci, Umberto Basso, Giampietro Gasparini, Mario D'Andrea, Paola Bonginelli, Emilio Bajetta, Marco Platania, Oscar Alabisio, Stefania Miraglia, Erica Bertona, Francesco Oniga, Rita Biason, Maria Concetta Chetrì, Palma Fedele, Giovanna Massara, Incoronata Romaniello, Maria Emanuela Negru, Monica Giordano, Giovanna LuchenaFranco Buzzi, Riccardo Ricotta, Salvatore Siena, Silvio Monfardini

Research output: Contribution to journalArticle

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Abstract

Background: The aim of this retrospective analysis was to evaluate the differences of 1-year treatment and chemotherapy related-toxicity in elderly colorectal cancer (CRC) patients in different Italian medical oncology units. Patients and Methods: An open questionnaire on the management of CRC patients over 70 years of age, from January to December 2004, was sent to Italian centres. One hundred and seventy-five files from 10 centres were analysed. Variables considered were age, gender, educational level, comorbidities and modality of therapy administration. Results: In only a minority of units were there some staff specifically dedicated to the older patients in close cooperation with geriatricians and the Multidimensional Geriatric Assessment (MGA) was not routinely used (11.2%-16.8% of cases). Only 5.7% patients were routinely enrolled in a protocol. In total, 95 out of 175 (54.3%) of CRC underwent adjuvant chemotherapy and 80 out of 175 (45.7%) received palliative chemotherapy. Of the patients who underwent adjuvant chemotherapy, 75.6% immediately accepted postoperative treatment while 12.2% were initially dubious but subsequently agreed. Only 5.5 and 9.7% of these patients reported very bad or bad tolerability, respectively. At disease progression, 62.5% patients accepted chemotherapy instantly while 33.3% accepted subsequently. Only 1.3% cases reported very bad and 1.3% bad tolerability. Conclusion: In those units in which the problem of the elderly is actually recognised, CRC treatment is adequate, not influenced by age discrimination but inhomogeneous. In the future, standardizing treatment in different oncology units could prove to be beneficial to this population.

Original languageEnglish
Pages (from-to)3601-3608
Number of pages8
JournalAnticancer Research
Volume27
Issue number5 B
Publication statusPublished - Sep 2007

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Medical Oncology
Italy
Colorectal Neoplasms
Therapeutics
Adjuvant Chemotherapy
Drug Therapy
Ageism
Geriatric Assessment
Disease Progression
Comorbidity

Keywords

  • Adjuvant
  • Colorectal cancer
  • Elderly
  • Palliative chemotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Colorectal cancer treatment in elderly patients : Results of a retrospective analysis addressed to the chiefs of medical oncology units in Italy. / Pasetto, Lara Maria; Falci, Cristina; Basso, Umberto; Gasparini, Giampietro; D'Andrea, Mario; Bonginelli, Paola; Bajetta, Emilio; Platania, Marco; Alabisio, Oscar; Miraglia, Stefania; Bertona, Erica; Oniga, Francesco; Biason, Rita; Chetrì, Maria Concetta; Fedele, Palma; Massara, Giovanna; Romaniello, Incoronata; Negru, Maria Emanuela; Giordano, Monica; Luchena, Giovanna; Buzzi, Franco; Ricotta, Riccardo; Siena, Salvatore; Monfardini, Silvio.

In: Anticancer Research, Vol. 27, No. 5 B, 09.2007, p. 3601-3608.

Research output: Contribution to journalArticle

Pasetto, LM, Falci, C, Basso, U, Gasparini, G, D'Andrea, M, Bonginelli, P, Bajetta, E, Platania, M, Alabisio, O, Miraglia, S, Bertona, E, Oniga, F, Biason, R, Chetrì, MC, Fedele, P, Massara, G, Romaniello, I, Negru, ME, Giordano, M, Luchena, G, Buzzi, F, Ricotta, R, Siena, S & Monfardini, S 2007, 'Colorectal cancer treatment in elderly patients: Results of a retrospective analysis addressed to the chiefs of medical oncology units in Italy', Anticancer Research, vol. 27, no. 5 B, pp. 3601-3608.
Pasetto, Lara Maria ; Falci, Cristina ; Basso, Umberto ; Gasparini, Giampietro ; D'Andrea, Mario ; Bonginelli, Paola ; Bajetta, Emilio ; Platania, Marco ; Alabisio, Oscar ; Miraglia, Stefania ; Bertona, Erica ; Oniga, Francesco ; Biason, Rita ; Chetrì, Maria Concetta ; Fedele, Palma ; Massara, Giovanna ; Romaniello, Incoronata ; Negru, Maria Emanuela ; Giordano, Monica ; Luchena, Giovanna ; Buzzi, Franco ; Ricotta, Riccardo ; Siena, Salvatore ; Monfardini, Silvio. / Colorectal cancer treatment in elderly patients : Results of a retrospective analysis addressed to the chiefs of medical oncology units in Italy. In: Anticancer Research. 2007 ; Vol. 27, No. 5 B. pp. 3601-3608.
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abstract = "Background: The aim of this retrospective analysis was to evaluate the differences of 1-year treatment and chemotherapy related-toxicity in elderly colorectal cancer (CRC) patients in different Italian medical oncology units. Patients and Methods: An open questionnaire on the management of CRC patients over 70 years of age, from January to December 2004, was sent to Italian centres. One hundred and seventy-five files from 10 centres were analysed. Variables considered were age, gender, educational level, comorbidities and modality of therapy administration. Results: In only a minority of units were there some staff specifically dedicated to the older patients in close cooperation with geriatricians and the Multidimensional Geriatric Assessment (MGA) was not routinely used (11.2{\%}-16.8{\%} of cases). Only 5.7{\%} patients were routinely enrolled in a protocol. In total, 95 out of 175 (54.3{\%}) of CRC underwent adjuvant chemotherapy and 80 out of 175 (45.7{\%}) received palliative chemotherapy. Of the patients who underwent adjuvant chemotherapy, 75.6{\%} immediately accepted postoperative treatment while 12.2{\%} were initially dubious but subsequently agreed. Only 5.5 and 9.7{\%} of these patients reported very bad or bad tolerability, respectively. At disease progression, 62.5{\%} patients accepted chemotherapy instantly while 33.3{\%} accepted subsequently. Only 1.3{\%} cases reported very bad and 1.3{\%} bad tolerability. Conclusion: In those units in which the problem of the elderly is actually recognised, CRC treatment is adequate, not influenced by age discrimination but inhomogeneous. In the future, standardizing treatment in different oncology units could prove to be beneficial to this population.",
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T1 - Colorectal cancer treatment in elderly patients

T2 - Results of a retrospective analysis addressed to the chiefs of medical oncology units in Italy

AU - Pasetto, Lara Maria

AU - Falci, Cristina

AU - Basso, Umberto

AU - Gasparini, Giampietro

AU - D'Andrea, Mario

AU - Bonginelli, Paola

AU - Bajetta, Emilio

AU - Platania, Marco

AU - Alabisio, Oscar

AU - Miraglia, Stefania

AU - Bertona, Erica

AU - Oniga, Francesco

AU - Biason, Rita

AU - Chetrì, Maria Concetta

AU - Fedele, Palma

AU - Massara, Giovanna

AU - Romaniello, Incoronata

AU - Negru, Maria Emanuela

AU - Giordano, Monica

AU - Luchena, Giovanna

AU - Buzzi, Franco

AU - Ricotta, Riccardo

AU - Siena, Salvatore

AU - Monfardini, Silvio

PY - 2007/9

Y1 - 2007/9

N2 - Background: The aim of this retrospective analysis was to evaluate the differences of 1-year treatment and chemotherapy related-toxicity in elderly colorectal cancer (CRC) patients in different Italian medical oncology units. Patients and Methods: An open questionnaire on the management of CRC patients over 70 years of age, from January to December 2004, was sent to Italian centres. One hundred and seventy-five files from 10 centres were analysed. Variables considered were age, gender, educational level, comorbidities and modality of therapy administration. Results: In only a minority of units were there some staff specifically dedicated to the older patients in close cooperation with geriatricians and the Multidimensional Geriatric Assessment (MGA) was not routinely used (11.2%-16.8% of cases). Only 5.7% patients were routinely enrolled in a protocol. In total, 95 out of 175 (54.3%) of CRC underwent adjuvant chemotherapy and 80 out of 175 (45.7%) received palliative chemotherapy. Of the patients who underwent adjuvant chemotherapy, 75.6% immediately accepted postoperative treatment while 12.2% were initially dubious but subsequently agreed. Only 5.5 and 9.7% of these patients reported very bad or bad tolerability, respectively. At disease progression, 62.5% patients accepted chemotherapy instantly while 33.3% accepted subsequently. Only 1.3% cases reported very bad and 1.3% bad tolerability. Conclusion: In those units in which the problem of the elderly is actually recognised, CRC treatment is adequate, not influenced by age discrimination but inhomogeneous. In the future, standardizing treatment in different oncology units could prove to be beneficial to this population.

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KW - Adjuvant

KW - Colorectal cancer

KW - Elderly

KW - Palliative chemotherapy

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