Abstract
Colostral lymphocytes were studied using two established T-cell markers: Intracytoplasmic alpha-naphtyl-acetate esterase (ANAE) staining and membrane receptors for sheep erythrocytes (E rosettes). ANAE staining allowed counting and identification of T-cell subsets independently of the status of membrane structures and receptors frequently altered in colostral cells. The fact that a sizeable number of colostral lymphocytes had the same phenotype as the majority of mature circulating peripheral blood lymphocytes supports the hypothesis that colostral lymphocytes may play a role in protecting neonates against infections, in transferring immune information to the newborn, or in modulating the immune response via release of soluble factors. A considerable percentage of colostral T lymphocytes are ANAE-negative. This phenotype is similar to that observed among thymocytes.
Original language | English |
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Pages (from-to) | 217-221 |
Number of pages | 5 |
Journal | Neonatology |
Volume | 42 |
Issue number | 5-6 |
DOIs | |
Publication status | Published - 1982 |
Keywords
- Colostrum
- Neonatal immunology
- Newborn
- T lymphocytes
ASJC Scopus subject areas
- Developmental Biology
- Pediatrics, Perinatology, and Child Health