Abstract
Colostral lymphocytes were studied using two established T-cell markers: Intracytoplasmic alpha-naphtyl-acetate esterase (ANAE) staining and membrane receptors for sheep erythrocytes (E rosettes). ANAE staining allowed counting and identification of T-cell subsets independently of the status of membrane structures and receptors frequently altered in colostral cells. The fact that a sizeable number of colostral lymphocytes had the same phenotype as the majority of mature circulating peripheral blood lymphocytes supports the hypothesis that colostral lymphocytes may play a role in protecting neonates against infections, in transferring immune information to the newborn, or in modulating the immune response via release of soluble factors. A considerable percentage of colostral T lymphocytes are ANAE-negative. This phenotype is similar to that observed among thymocytes.
| Original language | English |
|---|---|
| Pages (from-to) | 217-221 |
| Number of pages | 5 |
| Journal | Neonatology |
| Volume | 42 |
| Issue number | 5-6 |
| DOIs | |
| Publication status | Published - 1982 |
Fingerprint
Keywords
- Colostrum
- Neonatal immunology
- Newborn
- T lymphocytes
ASJC Scopus subject areas
- Developmental Biology
- Pediatrics, Perinatology, and Child Health
Cite this
Colostral t lymphocytes detected by intracytoplasmic and membrane markers. / Pignata, C.; Nespol, L.; Maccario, R.; Siena, S.; M Ingrat, G.; Mazzucco, M.; Ugazio, A. G.
In: Neonatology, Vol. 42, No. 5-6, 1982, p. 217-221.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Colostral t lymphocytes detected by intracytoplasmic and membrane markers
AU - Pignata, C.
AU - Nespol, L.
AU - Maccario, R.
AU - Siena, S.
AU - M Ingrat, G.
AU - Mazzucco, M.
AU - Ugazio, A. G.
PY - 1982
Y1 - 1982
N2 - Colostral lymphocytes were studied using two established T-cell markers: Intracytoplasmic alpha-naphtyl-acetate esterase (ANAE) staining and membrane receptors for sheep erythrocytes (E rosettes). ANAE staining allowed counting and identification of T-cell subsets independently of the status of membrane structures and receptors frequently altered in colostral cells. The fact that a sizeable number of colostral lymphocytes had the same phenotype as the majority of mature circulating peripheral blood lymphocytes supports the hypothesis that colostral lymphocytes may play a role in protecting neonates against infections, in transferring immune information to the newborn, or in modulating the immune response via release of soluble factors. A considerable percentage of colostral T lymphocytes are ANAE-negative. This phenotype is similar to that observed among thymocytes.
AB - Colostral lymphocytes were studied using two established T-cell markers: Intracytoplasmic alpha-naphtyl-acetate esterase (ANAE) staining and membrane receptors for sheep erythrocytes (E rosettes). ANAE staining allowed counting and identification of T-cell subsets independently of the status of membrane structures and receptors frequently altered in colostral cells. The fact that a sizeable number of colostral lymphocytes had the same phenotype as the majority of mature circulating peripheral blood lymphocytes supports the hypothesis that colostral lymphocytes may play a role in protecting neonates against infections, in transferring immune information to the newborn, or in modulating the immune response via release of soluble factors. A considerable percentage of colostral T lymphocytes are ANAE-negative. This phenotype is similar to that observed among thymocytes.
KW - Colostrum
KW - Neonatal immunology
KW - Newborn
KW - T lymphocytes
UR - http://www.scopus.com/inward/record.url?scp=0020468142&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020468142&partnerID=8YFLogxK
U2 - 10.1159/000241602
DO - 10.1159/000241602
M3 - Article
VL - 42
SP - 217
EP - 221
JO - Neonatology
JF - Neonatology
SN - 1661-7800
IS - 5-6
ER -