Colostral t lymphocytes detected by intracytoplasmic and membrane markers

C. Pignata, L. Nespol, R. Maccario, S. Siena, G. M Ingrat, M. Mazzucco, A. G. Ugazio

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Colostral lymphocytes were studied using two established T-cell markers: Intracytoplasmic alpha-naphtyl-acetate esterase (ANAE) staining and membrane receptors for sheep erythrocytes (E rosettes). ANAE staining allowed counting and identification of T-cell subsets independently of the status of membrane structures and receptors frequently altered in colostral cells. The fact that a sizeable number of colostral lymphocytes had the same phenotype as the majority of mature circulating peripheral blood lymphocytes supports the hypothesis that colostral lymphocytes may play a role in protecting neonates against infections, in transferring immune information to the newborn, or in modulating the immune response via release of soluble factors. A considerable percentage of colostral T lymphocytes are ANAE-negative. This phenotype is similar to that observed among thymocytes.

Original languageEnglish
Pages (from-to)217-221
Number of pages5
JournalNeonatology
Volume42
Issue number5-6
DOIs
Publication statusPublished - 1982

Fingerprint

Acetylesterase
Lymphocytes
Membranes
Staining and Labeling
T-Lymphocytes
Phenotype
Lymphocyte Count
T-Lymphocyte Subsets
Thymocytes
Sheep
Erythrocytes
Infection

Keywords

  • Colostrum
  • Neonatal immunology
  • Newborn
  • T lymphocytes

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

Cite this

Pignata, C., Nespol, L., Maccario, R., Siena, S., M Ingrat, G., Mazzucco, M., & Ugazio, A. G. (1982). Colostral t lymphocytes detected by intracytoplasmic and membrane markers. Neonatology, 42(5-6), 217-221. https://doi.org/10.1159/000241602

Colostral t lymphocytes detected by intracytoplasmic and membrane markers. / Pignata, C.; Nespol, L.; Maccario, R.; Siena, S.; M Ingrat, G.; Mazzucco, M.; Ugazio, A. G.

In: Neonatology, Vol. 42, No. 5-6, 1982, p. 217-221.

Research output: Contribution to journalArticle

Pignata, C, Nespol, L, Maccario, R, Siena, S, M Ingrat, G, Mazzucco, M & Ugazio, AG 1982, 'Colostral t lymphocytes detected by intracytoplasmic and membrane markers', Neonatology, vol. 42, no. 5-6, pp. 217-221. https://doi.org/10.1159/000241602
Pignata C, Nespol L, Maccario R, Siena S, M Ingrat G, Mazzucco M et al. Colostral t lymphocytes detected by intracytoplasmic and membrane markers. Neonatology. 1982;42(5-6):217-221. https://doi.org/10.1159/000241602
Pignata, C. ; Nespol, L. ; Maccario, R. ; Siena, S. ; M Ingrat, G. ; Mazzucco, M. ; Ugazio, A. G. / Colostral t lymphocytes detected by intracytoplasmic and membrane markers. In: Neonatology. 1982 ; Vol. 42, No. 5-6. pp. 217-221.
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