Colostral t lymphocytes detected by intracytoplasmic and membrane markers

C. Pignata, L. Nespol, R. Maccario, S. Siena, G. M Ingrat, M. Mazzucco, A. G. Ugazio

Research output: Contribution to journalArticlepeer-review


Colostral lymphocytes were studied using two established T-cell markers: Intracytoplasmic alpha-naphtyl-acetate esterase (ANAE) staining and membrane receptors for sheep erythrocytes (E rosettes). ANAE staining allowed counting and identification of T-cell subsets independently of the status of membrane structures and receptors frequently altered in colostral cells. The fact that a sizeable number of colostral lymphocytes had the same phenotype as the majority of mature circulating peripheral blood lymphocytes supports the hypothesis that colostral lymphocytes may play a role in protecting neonates against infections, in transferring immune information to the newborn, or in modulating the immune response via release of soluble factors. A considerable percentage of colostral T lymphocytes are ANAE-negative. This phenotype is similar to that observed among thymocytes.

Original languageEnglish
Pages (from-to)217-221
Number of pages5
Issue number5-6
Publication statusPublished - 1982


  • Colostrum
  • Neonatal immunology
  • Newborn
  • T lymphocytes

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health


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