Abstract
Noninvasive breast lesions encompass a heterogeneous group of risk indicators and nonobligate precursors of breast cancer, such as apocrine hyperplasia (AH) and columnar cell lesions (CCLs). Given the different expression of ER and ER-regulated genes in AH and CCL, these two alterations are currently considered discrete conditions. However, whether they share early biologic changes is not clear to date. Here, we sought to define the clinicopathologic and immunohistochemical features of a prospective series of combined lesions made up by CCLs and AH forming a continuum within single terminal duct-lobular units. The study group included 19 cases, whereas 25 cases of synchronous contiguous CCLs and AH served as control group. The different components of each case were subjected to immunohistochemical analysis for ER, PR, AR, HER2, BCL2, CCND1, MUC1, and PIP. Although CCLs and AHs arising in continuity showed opposite patterns of ER expression, the PIP-positive apocrine signature was consistently present in both components. In conclusion, apocrine changes are highly recurrent in CCLs growing within foci of AH, regardless of the ER activation. Our results suggest that PIP-positive and PIP-negative CCLs are likely to represent biologically distinct conditions and that apocrine changes might occur earlier than ER activation in the natural history of breast precursor lesions.
| Original language | English |
|---|---|
| Pages (from-to) | 508-514 |
| Number of pages | 7 |
| Journal | Applied Immunohistochemistry and Molecular Morphology |
| Volume | 27 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Aug 1 2019 |
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Keywords
- apocrine hyperplasia
- breast
- columnar cell lesion
- fibrocystic changes
- GCDFP15
- immunohistochemistry
- PIP
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology
- Medical Laboratory Technology
Cite this
Columnar Cell Lesion and Apocrine Hyperplasia of the Breast : Is There a Common Origin? the Role of Prolactin-induced Protein. / Sciarra, Amedeo; Lopez, Gianluca; Corti, Chiara; Runza, Letterio; Ercoli, Giulia; Bonometti, Arturo; Despini, Luca; Blundo, Concetta; Gambini, Donatella; Fusco, Nicola.
In: Applied Immunohistochemistry and Molecular Morphology, Vol. 27, No. 7, 01.08.2019, p. 508-514.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Columnar Cell Lesion and Apocrine Hyperplasia of the Breast
T2 - Is There a Common Origin? the Role of Prolactin-induced Protein
AU - Sciarra, Amedeo
AU - Lopez, Gianluca
AU - Corti, Chiara
AU - Runza, Letterio
AU - Ercoli, Giulia
AU - Bonometti, Arturo
AU - Despini, Luca
AU - Blundo, Concetta
AU - Gambini, Donatella
AU - Fusco, Nicola
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Noninvasive breast lesions encompass a heterogeneous group of risk indicators and nonobligate precursors of breast cancer, such as apocrine hyperplasia (AH) and columnar cell lesions (CCLs). Given the different expression of ER and ER-regulated genes in AH and CCL, these two alterations are currently considered discrete conditions. However, whether they share early biologic changes is not clear to date. Here, we sought to define the clinicopathologic and immunohistochemical features of a prospective series of combined lesions made up by CCLs and AH forming a continuum within single terminal duct-lobular units. The study group included 19 cases, whereas 25 cases of synchronous contiguous CCLs and AH served as control group. The different components of each case were subjected to immunohistochemical analysis for ER, PR, AR, HER2, BCL2, CCND1, MUC1, and PIP. Although CCLs and AHs arising in continuity showed opposite patterns of ER expression, the PIP-positive apocrine signature was consistently present in both components. In conclusion, apocrine changes are highly recurrent in CCLs growing within foci of AH, regardless of the ER activation. Our results suggest that PIP-positive and PIP-negative CCLs are likely to represent biologically distinct conditions and that apocrine changes might occur earlier than ER activation in the natural history of breast precursor lesions.
AB - Noninvasive breast lesions encompass a heterogeneous group of risk indicators and nonobligate precursors of breast cancer, such as apocrine hyperplasia (AH) and columnar cell lesions (CCLs). Given the different expression of ER and ER-regulated genes in AH and CCL, these two alterations are currently considered discrete conditions. However, whether they share early biologic changes is not clear to date. Here, we sought to define the clinicopathologic and immunohistochemical features of a prospective series of combined lesions made up by CCLs and AH forming a continuum within single terminal duct-lobular units. The study group included 19 cases, whereas 25 cases of synchronous contiguous CCLs and AH served as control group. The different components of each case were subjected to immunohistochemical analysis for ER, PR, AR, HER2, BCL2, CCND1, MUC1, and PIP. Although CCLs and AHs arising in continuity showed opposite patterns of ER expression, the PIP-positive apocrine signature was consistently present in both components. In conclusion, apocrine changes are highly recurrent in CCLs growing within foci of AH, regardless of the ER activation. Our results suggest that PIP-positive and PIP-negative CCLs are likely to represent biologically distinct conditions and that apocrine changes might occur earlier than ER activation in the natural history of breast precursor lesions.
KW - apocrine hyperplasia
KW - breast
KW - columnar cell lesion
KW - fibrocystic changes
KW - GCDFP15
KW - immunohistochemistry
KW - PIP
UR - http://www.scopus.com/inward/record.url?scp=85071268352&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85071268352&partnerID=8YFLogxK
U2 - 10.1097/PAI.0000000000000604
DO - 10.1097/PAI.0000000000000604
M3 - Article
C2 - 29084054
AN - SCOPUS:85071268352
VL - 27
SP - 508
EP - 514
JO - Applied Immunohistochemistry and Molecular Morphology
JF - Applied Immunohistochemistry and Molecular Morphology
SN - 1541-2016
IS - 7
ER -