Columnar cell variant of papillary thyroid carcinoma: Cytomorphological characteristics of 11 cases with histological correlation and literature review

Massimo Bongiovanni, Maxime Mermod, Sule Canberk, Chiara Saglietti, Gerasimos P. Sykiotis, Marc Pusztaszeri, Moira Ragazzi, Luca Mazzucchelli, Luca Giovanella, Simonetta Piana

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The columnar cell variant of papillary thyroid carcinoma (PTC-CCV) is a rare entity that demonstrates a more aggressive clinical course compared with the more common subtypes of PTC. On histology, it is defined by papillae or gland-like structures lined by columnar cells displaying prominent nuclear stratification. Because to the authors' knowledge no characteristic cytomorphological features have been identified to date and typical features of PTC often are absent on cytology, the diagnosis of PTC-CCV by fine-needle aspiration (FNA) is challenging. This prompted the authors to evaluate a series of PTC-CCV cases to identify features that could facilitate its diagnosis by FNA. METHODS: A total of 11 surgical specimens of PTC-CCV with corresponding preoperative cytology were identified over a 21-year period. The cytological features of the aspirated specimens, consisting mostly of Papanicolaou and Diff-Quick smears, were evaluated retrospectively. RESULTS: All cases demonstrated the presence of papillary structures. The most important features observed in PTC-CCV FNA specimens were hypercellularity with nuclear superposition and a paucity of nuclear pseudoinclusions and grooves. CONCLUSIONS: Although PTC-CCV may demonstrate features that overlap with those of the classic variant of PTC, hypercellular smears with papillary structures covered by cells with pseudostratified nuclei that show a paucity of nuclear pseudoinclusions and grooves should alert the cytopathologist to the possibility of this diagnosis. Cancer Cytopathol 2017;125:389–97.

Original languageEnglish
Pages (from-to)389-397
Number of pages9
JournalCancer cytopathology
Volume125
Issue number6
DOIs
Publication statusPublished - Jun 1 2017

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Factor IX
Fine Needle Biopsy
Cell Biology
Papillary Thyroid cancer
Histology

Keywords

  • columnar cell variant
  • differential diagnosis
  • fine-needle aspiration (FNA)
  • papillary thyroid carcinoma (PTC)
  • thyroid cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Columnar cell variant of papillary thyroid carcinoma : Cytomorphological characteristics of 11 cases with histological correlation and literature review. / Bongiovanni, Massimo; Mermod, Maxime; Canberk, Sule; Saglietti, Chiara; Sykiotis, Gerasimos P.; Pusztaszeri, Marc; Ragazzi, Moira; Mazzucchelli, Luca; Giovanella, Luca; Piana, Simonetta.

In: Cancer cytopathology, Vol. 125, No. 6, 01.06.2017, p. 389-397.

Research output: Contribution to journalArticle

Bongiovanni, M, Mermod, M, Canberk, S, Saglietti, C, Sykiotis, GP, Pusztaszeri, M, Ragazzi, M, Mazzucchelli, L, Giovanella, L & Piana, S 2017, 'Columnar cell variant of papillary thyroid carcinoma: Cytomorphological characteristics of 11 cases with histological correlation and literature review', Cancer cytopathology, vol. 125, no. 6, pp. 389-397. https://doi.org/10.1002/cncy.21860
Bongiovanni, Massimo ; Mermod, Maxime ; Canberk, Sule ; Saglietti, Chiara ; Sykiotis, Gerasimos P. ; Pusztaszeri, Marc ; Ragazzi, Moira ; Mazzucchelli, Luca ; Giovanella, Luca ; Piana, Simonetta. / Columnar cell variant of papillary thyroid carcinoma : Cytomorphological characteristics of 11 cases with histological correlation and literature review. In: Cancer cytopathology. 2017 ; Vol. 125, No. 6. pp. 389-397.
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AU - Pusztaszeri, Marc

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N2 - BACKGROUND: The columnar cell variant of papillary thyroid carcinoma (PTC-CCV) is a rare entity that demonstrates a more aggressive clinical course compared with the more common subtypes of PTC. On histology, it is defined by papillae or gland-like structures lined by columnar cells displaying prominent nuclear stratification. Because to the authors' knowledge no characteristic cytomorphological features have been identified to date and typical features of PTC often are absent on cytology, the diagnosis of PTC-CCV by fine-needle aspiration (FNA) is challenging. This prompted the authors to evaluate a series of PTC-CCV cases to identify features that could facilitate its diagnosis by FNA. METHODS: A total of 11 surgical specimens of PTC-CCV with corresponding preoperative cytology were identified over a 21-year period. The cytological features of the aspirated specimens, consisting mostly of Papanicolaou and Diff-Quick smears, were evaluated retrospectively. RESULTS: All cases demonstrated the presence of papillary structures. The most important features observed in PTC-CCV FNA specimens were hypercellularity with nuclear superposition and a paucity of nuclear pseudoinclusions and grooves. CONCLUSIONS: Although PTC-CCV may demonstrate features that overlap with those of the classic variant of PTC, hypercellular smears with papillary structures covered by cells with pseudostratified nuclei that show a paucity of nuclear pseudoinclusions and grooves should alert the cytopathologist to the possibility of this diagnosis. Cancer Cytopathol 2017;125:389–97.

AB - BACKGROUND: The columnar cell variant of papillary thyroid carcinoma (PTC-CCV) is a rare entity that demonstrates a more aggressive clinical course compared with the more common subtypes of PTC. On histology, it is defined by papillae or gland-like structures lined by columnar cells displaying prominent nuclear stratification. Because to the authors' knowledge no characteristic cytomorphological features have been identified to date and typical features of PTC often are absent on cytology, the diagnosis of PTC-CCV by fine-needle aspiration (FNA) is challenging. This prompted the authors to evaluate a series of PTC-CCV cases to identify features that could facilitate its diagnosis by FNA. METHODS: A total of 11 surgical specimens of PTC-CCV with corresponding preoperative cytology were identified over a 21-year period. The cytological features of the aspirated specimens, consisting mostly of Papanicolaou and Diff-Quick smears, were evaluated retrospectively. RESULTS: All cases demonstrated the presence of papillary structures. The most important features observed in PTC-CCV FNA specimens were hypercellularity with nuclear superposition and a paucity of nuclear pseudoinclusions and grooves. CONCLUSIONS: Although PTC-CCV may demonstrate features that overlap with those of the classic variant of PTC, hypercellular smears with papillary structures covered by cells with pseudostratified nuclei that show a paucity of nuclear pseudoinclusions and grooves should alert the cytopathologist to the possibility of this diagnosis. Cancer Cytopathol 2017;125:389–97.

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