Combination chemotherapy and radiotherapy in non Hodgkin's lymphomata

G. Bonadonna, M. de Lena, A. Lattuada, F. Milani, S. Monfardini, G. Beretta

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The results obtained with intensive chemotherapy and intensive chemotherapy plus radiotherapy in non Hodgkin's lymphomata are reported. A quintuple drug regimen (mechloretamine, adriamycin, bleomycin, vincristine and prednisone) in histiocytic lymphomata (Stage III and IV) yielded complete remission in 53% and complete plus partial remissions in 77%. These figures were 44% and 64% respectively in lymphocytic lymphoma. In Stage III complete responders after combination chemotherapy were subsequently irradiated (involved field irradiation). The median duration of complete remission after completion of radiotherapy was 9.5 mth in histiocytic and 12 mth in lymphocytic lymphomata. At 2 yr actuarial survival in Stage III and IV was better in patients with lymphocytic type and with nodular pattern than with histiocytic and diffuse patterns. A more recent trial compares, in Stage IV patients, cyclophosphamide, vincristine and prednisone (CVP) versus adriamycin, bleomycin and prednisone (ABP). Although the number of evaluable patients is still limited, there appears to be no difference in the response rate between CVP and ABP. In Stage I and II, 6 cycles of CVP were given as adjuvant treatment after radiotherapy. At present there is no statistical difference in the relapse rate between the group of patients treated with radiotherapy alone and that with radiotherapy plus CVP.

Original languageEnglish
Pages (from-to)481-488
Number of pages8
JournalBritish Journal of Cancer
Issue numbersup. II
Publication statusPublished - 1975

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Bonadonna, G., de Lena, M., Lattuada, A., Milani, F., Monfardini, S., & Beretta, G. (1975). Combination chemotherapy and radiotherapy in non Hodgkin's lymphomata. British Journal of Cancer, 31(sup. II), 481-488.