Combination chemotherapy with cisplatin and etoposide associated with radiotherapy in the treatment of small-cell lung cancer

F. Figoli, A. Veronesi, M. G. Trovo, D. Errante, M. Della Valentina, V. Zagonel, R. Talamini, M. D. Magri, S. Monfardini

Research output: Contribution to journalArticle

Abstract

A total of 52 consecutive, previously untreated patients with small-cell lung cancer (SCLC) were scheduled to receive six cycles of a combination of etoposide (75 mg/m2 per day) and cisplatin (20 mg/m2 per day), each cycle given over 5 consecutive days. In all, 28 patients had extensive disease (ED) and 24, limited disease (LD). After three cycles of chemotherapy, all responding patients were given chest radiotherapy (RT) (45 Gy in two split courses and 30 Gy in LD and ED, respectively); only patients with LD who achieved complete remission (CR) after three cycles of chemotherapy were given prophylactic brain irradiation (30 Gy). In the 51 evaluable patients, the overall response rate was 90%, with a 31% CR and a 59% partial remission (PR) rate. In LD and ED patients, 57% and 11% CR rates and 30% and 82% PR rates were noted, respectively. Myelosuppression was the most frequently observed toxicity. The median duration of response was 12 months in LD (range, 3-41+months) and 7 months (range, 2-12 months) in ED; the median survival was 15 months in LD and 9.3 months in ED, respectively. In all 30% of LD patients are alive and well at a minimal follow-up of 18 months. This trial confirms the activity of the cisplatinetoposide combination in SCLC.

Original languageEnglish
Pages (from-to)381-385
Number of pages5
JournalCancer Chemotherapy and Pharmacology
Volume24
Issue number6
DOIs
Publication statusPublished - Nov 1989

ASJC Scopus subject areas

  • Pharmacology
  • Oncology
  • Cancer Research

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    Figoli, F., Veronesi, A., Trovo, M. G., Errante, D., Valentina, M. D., Zagonel, V., Talamini, R., Magri, M. D., & Monfardini, S. (1989). Combination chemotherapy with cisplatin and etoposide associated with radiotherapy in the treatment of small-cell lung cancer. Cancer Chemotherapy and Pharmacology, 24(6), 381-385. https://doi.org/10.1007/BF00257447