Combination chemotherapy with fluorouracil, adriamycin, cis-Platinum and VM-26 in advanced transitional cell carcinoma of the urinary tract

A. Veronesi, E. Galligioni, G. Lo Re, R. Sorio, S. Saracchini, M. Francini, A. Merlo, V. Dal Bo, S. Monfardini

Research output: Contribution to journalArticle


From October 1981 to October 1984, 42 consecutive patients with locally advanced unresectable or metastatic transitional cell carcinoma of the urinary tract were treated with cis-Platinum 50 mg/m2 i.v. and Adriamycin 50 mg/m2 i.v. day 1, and Fluorouracil 500mg/m2 i.v. and VM26 100 mg/m2 days 1 and 8, every 3 weeks. In the 36 evaluable patients, 4 complete remissions and 15 partial remissions were noted (52.7% response rate). Of the 12 patients with previously untreated, locally advanced bladder carcinoma, 8 responded, with 3 pathologically confirmed complete remissions. Toxicity was moderate. Median survival was 44 weeks. This 4-drug combination had significant palliative activity in our patient population. Its role in the preoperative setting deserves further evaluation.

Original languageEnglish
Pages (from-to)1457-1460
Number of pages4
JournalEuropean Journal of Cancer and Clinical Oncology
Issue number12
Publication statusPublished - 1986


ASJC Scopus subject areas

  • Oncology

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