Combination of biomarkers to predict mortality in elderly patients with myocardial infarction

Fabiola Olivieri; Liana Spazzafumo; Roberto Antonicelli; Francesca Marchegiani; Maurizio Cardelli; Cristina Sirolla; Roberta Galeazzi; Simona Giovagnetti; Eugenio Mocchegiani; Claudio Franceschi

doi:10.1016/j.mad.2008.01.002

Combination of biomarkers to predict mortality in elderly patients with myocardial infarction

Fabiola Olivieri, Liana Spazzafumo, Roberto Antonicelli, Francesca Marchegiani, Maurizio Cardelli, Cristina Sirolla, Roberta Galeazzi, Simona Giovagnetti, Eugenio Mocchegiani, Claudio Franceschi

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: The elderly subjects affected by Acute Myocardial Infarction (AMI) have the highest risk of mortality. Our study was designed to improve the capability of mortality risk stratification in elderly AMI patients through the concurrent evaluations of different biomarkers, including genetic markers. Methods and results: One-year follow-up study was performed in 250 elderly AMI patients. The combination of high total Homocysteine (tHcy), low folate and vitamin B12 plasma levels (18.0 ± 9.0 μmol/l; 4.4 ± 1.2 ng/ml; 404.2 ± 287.5 pg/ml, respectively) and elevated CRP plasma levels (≥6 mg/dl) identify the highest-risk pathway of heart mortality (RR = 4.20, IC 95% 1.62-10.89, P <0.002) with respect to the combination of low total tHcy, high folate and vitamin B12 plasma levels (12.4 ± 5.2 μmol/l; 8.9 ± 2.5 ng/ml; 546.9 ± 379.8 pg/ml, respectively) and low CRP plasma levels (

Original language	English
Pages (from-to)	231-237
Number of pages	7
Journal	Mechanisms of Ageing and Development
Volume	129
Issue number	4
DOIs	https://doi.org/10.1016/j.mad.2008.01.002
Publication status	Published - Apr 2008

Keywords

Acute myocardial infarction
CRP
Decision-tree analysis
Elderly cardiovascular patients
Homocysteine

ASJC Scopus subject areas

Ageing
Biochemistry
Developmental Biology
Developmental Neuroscience

Access to Document

10.1016/j.mad.2008.01.002

Cite this

Combination of biomarkers to predict mortality in elderly patients with myocardial infarction. / Olivieri, Fabiola; Spazzafumo, Liana; Antonicelli, Roberto ; Marchegiani, Francesca ; Cardelli, Maurizio; Sirolla, Cristina; Galeazzi, Roberta; Giovagnetti, Simona; Mocchegiani, Eugenio; Franceschi, Claudio.

In: Mechanisms of Ageing and Development, Vol. 129, No. 4, 04.2008, p. 231-237.

Research output: Contribution to journal › Article › peer-review

Olivieri, Fabiola ; Spazzafumo, Liana ; Antonicelli, Roberto ; Marchegiani, Francesca ; Cardelli, Maurizio ; Sirolla, Cristina ; Galeazzi, Roberta ; Giovagnetti, Simona ; Mocchegiani, Eugenio ; Franceschi, Claudio. / Combination of biomarkers to predict mortality in elderly patients with myocardial infarction. In: Mechanisms of Ageing and Development. 2008 ; Vol. 129, No. 4. pp. 231-237.

@article{c1bc4b92aa474845a1a786fb8c076352,

title = "Combination of biomarkers to predict mortality in elderly patients with myocardial infarction",

abstract = "Objective: The elderly subjects affected by Acute Myocardial Infarction (AMI) have the highest risk of mortality. Our study was designed to improve the capability of mortality risk stratification in elderly AMI patients through the concurrent evaluations of different biomarkers, including genetic markers. Methods and results: One-year follow-up study was performed in 250 elderly AMI patients. The combination of high total Homocysteine (tHcy), low folate and vitamin B12 plasma levels (18.0 ± 9.0 μmol/l; 4.4 ± 1.2 ng/ml; 404.2 ± 287.5 pg/ml, respectively) and elevated CRP plasma levels (≥6 mg/dl) identify the highest-risk pathway of heart mortality (RR = 4.20, IC 95% 1.62-10.89, P <0.002) with respect to the combination of low total tHcy, high folate and vitamin B12 plasma levels (12.4 ± 5.2 μmol/l; 8.9 ± 2.5 ng/ml; 546.9 ± 379.8 pg/ml, respectively) and low CRP plasma levels (",

keywords = "Acute myocardial infarction, CRP, Decision-tree analysis, Elderly cardiovascular patients, Homocysteine",

author = "Fabiola Olivieri and Liana Spazzafumo and Roberto Antonicelli and Francesca Marchegiani and Maurizio Cardelli and Cristina Sirolla and Roberta Galeazzi and Simona Giovagnetti and Eugenio Mocchegiani and Claudio Franceschi",

year = "2008",

month = apr,

doi = "10.1016/j.mad.2008.01.002",

language = "English",

volume = "129",

pages = "231--237",

journal = "Mechanisms of Ageing and Development",

issn = "0047-6374",

publisher = "Elsevier Ireland Ltd",

number = "4",

}

TY - JOUR

T1 - Combination of biomarkers to predict mortality in elderly patients with myocardial infarction

AU - Olivieri, Fabiola

AU - Spazzafumo, Liana

AU - Antonicelli, Roberto

AU - Marchegiani, Francesca

AU - Cardelli, Maurizio

AU - Sirolla, Cristina

AU - Galeazzi, Roberta

AU - Giovagnetti, Simona

AU - Mocchegiani, Eugenio

AU - Franceschi, Claudio

PY - 2008/4

Y1 - 2008/4

N2 - Objective: The elderly subjects affected by Acute Myocardial Infarction (AMI) have the highest risk of mortality. Our study was designed to improve the capability of mortality risk stratification in elderly AMI patients through the concurrent evaluations of different biomarkers, including genetic markers. Methods and results: One-year follow-up study was performed in 250 elderly AMI patients. The combination of high total Homocysteine (tHcy), low folate and vitamin B12 plasma levels (18.0 ± 9.0 μmol/l; 4.4 ± 1.2 ng/ml; 404.2 ± 287.5 pg/ml, respectively) and elevated CRP plasma levels (≥6 mg/dl) identify the highest-risk pathway of heart mortality (RR = 4.20, IC 95% 1.62-10.89, P <0.002) with respect to the combination of low total tHcy, high folate and vitamin B12 plasma levels (12.4 ± 5.2 μmol/l; 8.9 ± 2.5 ng/ml; 546.9 ± 379.8 pg/ml, respectively) and low CRP plasma levels (

AB - Objective: The elderly subjects affected by Acute Myocardial Infarction (AMI) have the highest risk of mortality. Our study was designed to improve the capability of mortality risk stratification in elderly AMI patients through the concurrent evaluations of different biomarkers, including genetic markers. Methods and results: One-year follow-up study was performed in 250 elderly AMI patients. The combination of high total Homocysteine (tHcy), low folate and vitamin B12 plasma levels (18.0 ± 9.0 μmol/l; 4.4 ± 1.2 ng/ml; 404.2 ± 287.5 pg/ml, respectively) and elevated CRP plasma levels (≥6 mg/dl) identify the highest-risk pathway of heart mortality (RR = 4.20, IC 95% 1.62-10.89, P <0.002) with respect to the combination of low total tHcy, high folate and vitamin B12 plasma levels (12.4 ± 5.2 μmol/l; 8.9 ± 2.5 ng/ml; 546.9 ± 379.8 pg/ml, respectively) and low CRP plasma levels (

KW - Acute myocardial infarction

KW - CRP

KW - Decision-tree analysis

KW - Elderly cardiovascular patients

KW - Homocysteine

UR - http://www.scopus.com/inward/record.url?scp=39949085938&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=39949085938&partnerID=8YFLogxK

U2 - 10.1016/j.mad.2008.01.002

DO - 10.1016/j.mad.2008.01.002

M3 - Article

C2 - 18299144

AN - SCOPUS:39949085938

VL - 129

SP - 231

EP - 237

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

SN - 0047-6374

IS - 4

ER -

Combination of biomarkers to predict mortality in elderly patients with myocardial infarction

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this