Combination of biomarkers to predict mortality in elderly patients with myocardial infarction

Fabiola Olivieri, Liana Spazzafumo, Roberto Antonicelli, Francesca Marchegiani, Maurizio Cardelli, Cristina Sirolla, Roberta Galeazzi, Simona Giovagnetti, Eugenio Mocchegiani, Claudio Franceschi

Research output: Contribution to journalArticle

Abstract

Objective: The elderly subjects affected by Acute Myocardial Infarction (AMI) have the highest risk of mortality. Our study was designed to improve the capability of mortality risk stratification in elderly AMI patients through the concurrent evaluations of different biomarkers, including genetic markers. Methods and results: One-year follow-up study was performed in 250 elderly AMI patients. The combination of high total Homocysteine (tHcy), low folate and vitamin B12 plasma levels (18.0 ± 9.0 μmol/l; 4.4 ± 1.2 ng/ml; 404.2 ± 287.5 pg/ml, respectively) and elevated CRP plasma levels (≥6 mg/dl) identify the highest-risk pathway of heart mortality (RR = 4.20, IC 95% 1.62-10.89, P <0.002) with respect to the combination of low total tHcy, high folate and vitamin B12 plasma levels (12.4 ± 5.2 μmol/l; 8.9 ± 2.5 ng/ml; 546.9 ± 379.8 pg/ml, respectively) and low CRP plasma levels (

Original languageEnglish
Pages (from-to)231-237
Number of pages7
JournalMechanisms of Ageing and Development
Volume129
Issue number4
DOIs
Publication statusPublished - Apr 2008

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Keywords

  • Acute myocardial infarction
  • CRP
  • Decision-tree analysis
  • Elderly cardiovascular patients
  • Homocysteine

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

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