TY - JOUR
T1 - Combination of biomarkers to predict mortality in elderly patients with myocardial infarction
AU - Olivieri, Fabiola
AU - Spazzafumo, Liana
AU - Antonicelli, Roberto
AU - Marchegiani, Francesca
AU - Cardelli, Maurizio
AU - Sirolla, Cristina
AU - Galeazzi, Roberta
AU - Giovagnetti, Simona
AU - Mocchegiani, Eugenio
AU - Franceschi, Claudio
PY - 2008/4
Y1 - 2008/4
N2 - Objective: The elderly subjects affected by Acute Myocardial Infarction (AMI) have the highest risk of mortality. Our study was designed to improve the capability of mortality risk stratification in elderly AMI patients through the concurrent evaluations of different biomarkers, including genetic markers. Methods and results: One-year follow-up study was performed in 250 elderly AMI patients. The combination of high total Homocysteine (tHcy), low folate and vitamin B12 plasma levels (18.0 ± 9.0 μmol/l; 4.4 ± 1.2 ng/ml; 404.2 ± 287.5 pg/ml, respectively) and elevated CRP plasma levels (≥6 mg/dl) identify the highest-risk pathway of heart mortality (RR = 4.20, IC 95% 1.62-10.89, P <0.002) with respect to the combination of low total tHcy, high folate and vitamin B12 plasma levels (12.4 ± 5.2 μmol/l; 8.9 ± 2.5 ng/ml; 546.9 ± 379.8 pg/ml, respectively) and low CRP plasma levels (
AB - Objective: The elderly subjects affected by Acute Myocardial Infarction (AMI) have the highest risk of mortality. Our study was designed to improve the capability of mortality risk stratification in elderly AMI patients through the concurrent evaluations of different biomarkers, including genetic markers. Methods and results: One-year follow-up study was performed in 250 elderly AMI patients. The combination of high total Homocysteine (tHcy), low folate and vitamin B12 plasma levels (18.0 ± 9.0 μmol/l; 4.4 ± 1.2 ng/ml; 404.2 ± 287.5 pg/ml, respectively) and elevated CRP plasma levels (≥6 mg/dl) identify the highest-risk pathway of heart mortality (RR = 4.20, IC 95% 1.62-10.89, P <0.002) with respect to the combination of low total tHcy, high folate and vitamin B12 plasma levels (12.4 ± 5.2 μmol/l; 8.9 ± 2.5 ng/ml; 546.9 ± 379.8 pg/ml, respectively) and low CRP plasma levels (
KW - Acute myocardial infarction
KW - CRP
KW - Decision-tree analysis
KW - Elderly cardiovascular patients
KW - Homocysteine
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U2 - 10.1016/j.mad.2008.01.002
DO - 10.1016/j.mad.2008.01.002
M3 - Article
C2 - 18299144
AN - SCOPUS:39949085938
VL - 129
SP - 231
EP - 237
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
SN - 0047-6374
IS - 4
ER -