Abstract
Guidelines on the treatment of metastatic squamous cell carcinoma of the penis are limited to a few prospective trials. Cisplatin-based regimens represent the standard of treatment with promising activity of taxanes. Recently, epidermal growth factor receptor overexpression has been shown in these patients. We treated an elderly man with a docetaxel-cetuximab combination after failure of the cisplatin regimen. We observed a necrosis of the inguinal lymph nodes and a reduction of F-fluorodeoxyglucose uptake at PET/CT scan. Only mild mucositis and skin toxicity had been detected. Our case report, the first in the literature, shows that this combination is active and well tolerated in penile squamous cell carcinoma.
| Original language | English |
|---|---|
| Pages (from-to) | 573-577 |
| Number of pages | 5 |
| Journal | Anti-Cancer Drugs |
| Volume | 23 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Jun 2012 |
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Keywords
- cetuximab
- chemotherapy
- metastatic penile cancer
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Cancer Research
- Oncology
Cite this
Combination of docetaxel and cetuximab for penile cancer : A case report and literature review. / Rescigno, Pasquale; Matano, Elide; Raimondo, Lucia; Mainolfi, Ciro; Federico, Piera; Buonerba, Carlo; Di Trolio, Rossella; D'Aniello, Carmine; Damiano, Vincenzo; Palmieri, Giovannella; De Placido, Sabino; Di Lorenzo, Giuseppe.
In: Anti-Cancer Drugs, Vol. 23, No. 5, 06.2012, p. 573-577.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Combination of docetaxel and cetuximab for penile cancer
T2 - A case report and literature review
AU - Rescigno, Pasquale
AU - Matano, Elide
AU - Raimondo, Lucia
AU - Mainolfi, Ciro
AU - Federico, Piera
AU - Buonerba, Carlo
AU - Di Trolio, Rossella
AU - D'Aniello, Carmine
AU - Damiano, Vincenzo
AU - Palmieri, Giovannella
AU - De Placido, Sabino
AU - Di Lorenzo, Giuseppe
PY - 2012/6
Y1 - 2012/6
N2 - Guidelines on the treatment of metastatic squamous cell carcinoma of the penis are limited to a few prospective trials. Cisplatin-based regimens represent the standard of treatment with promising activity of taxanes. Recently, epidermal growth factor receptor overexpression has been shown in these patients. We treated an elderly man with a docetaxel-cetuximab combination after failure of the cisplatin regimen. We observed a necrosis of the inguinal lymph nodes and a reduction of F-fluorodeoxyglucose uptake at PET/CT scan. Only mild mucositis and skin toxicity had been detected. Our case report, the first in the literature, shows that this combination is active and well tolerated in penile squamous cell carcinoma.
AB - Guidelines on the treatment of metastatic squamous cell carcinoma of the penis are limited to a few prospective trials. Cisplatin-based regimens represent the standard of treatment with promising activity of taxanes. Recently, epidermal growth factor receptor overexpression has been shown in these patients. We treated an elderly man with a docetaxel-cetuximab combination after failure of the cisplatin regimen. We observed a necrosis of the inguinal lymph nodes and a reduction of F-fluorodeoxyglucose uptake at PET/CT scan. Only mild mucositis and skin toxicity had been detected. Our case report, the first in the literature, shows that this combination is active and well tolerated in penile squamous cell carcinoma.
KW - cetuximab
KW - chemotherapy
KW - metastatic penile cancer
UR - http://www.scopus.com/inward/record.url?scp=84859641835&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84859641835&partnerID=8YFLogxK
U2 - 10.1097/CAD.0b013e328350ead7
DO - 10.1097/CAD.0b013e328350ead7
M3 - Article
C2 - 22481064
AN - SCOPUS:84859641835
VL - 23
SP - 573
EP - 577
JO - Anti-Cancer Drugs
JF - Anti-Cancer Drugs
SN - 0959-4973
IS - 5
ER -