Combination of docetaxel and cetuximab for penile cancer: A case report and literature review

Pasquale Rescigno, Elide Matano, Lucia Raimondo, Ciro Mainolfi, Piera Federico, Carlo Buonerba, Rossella Di Trolio, Carmine D'Aniello, Vincenzo Damiano, Giovannella Palmieri, Sabino De Placido, Giuseppe Di Lorenzo

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Guidelines on the treatment of metastatic squamous cell carcinoma of the penis are limited to a few prospective trials. Cisplatin-based regimens represent the standard of treatment with promising activity of taxanes. Recently, epidermal growth factor receptor overexpression has been shown in these patients. We treated an elderly man with a docetaxel-cetuximab combination after failure of the cisplatin regimen. We observed a necrosis of the inguinal lymph nodes and a reduction of F-fluorodeoxyglucose uptake at PET/CT scan. Only mild mucositis and skin toxicity had been detected. Our case report, the first in the literature, shows that this combination is active and well tolerated in penile squamous cell carcinoma.

Original languageEnglish
Pages (from-to)573-577
Number of pages5
JournalAnti-Cancer Drugs
Volume23
Issue number5
DOIs
Publication statusPublished - Jun 2012

Fingerprint

docetaxel
Penile Neoplasms
Cisplatin
Squamous Cell Carcinoma
Taxoids
Mucositis
Groin
Penis
Epidermal Growth Factor Receptor
Necrosis
Lymph Nodes
Guidelines
Skin
Therapeutics
Cetuximab

Keywords

  • cetuximab
  • chemotherapy
  • metastatic penile cancer

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Cancer Research
  • Oncology

Cite this

Rescigno, P., Matano, E., Raimondo, L., Mainolfi, C., Federico, P., Buonerba, C., ... Di Lorenzo, G. (2012). Combination of docetaxel and cetuximab for penile cancer: A case report and literature review. Anti-Cancer Drugs, 23(5), 573-577. https://doi.org/10.1097/CAD.0b013e328350ead7

Combination of docetaxel and cetuximab for penile cancer : A case report and literature review. / Rescigno, Pasquale; Matano, Elide; Raimondo, Lucia; Mainolfi, Ciro; Federico, Piera; Buonerba, Carlo; Di Trolio, Rossella; D'Aniello, Carmine; Damiano, Vincenzo; Palmieri, Giovannella; De Placido, Sabino; Di Lorenzo, Giuseppe.

In: Anti-Cancer Drugs, Vol. 23, No. 5, 06.2012, p. 573-577.

Research output: Contribution to journalArticle

Rescigno, P, Matano, E, Raimondo, L, Mainolfi, C, Federico, P, Buonerba, C, Di Trolio, R, D'Aniello, C, Damiano, V, Palmieri, G, De Placido, S & Di Lorenzo, G 2012, 'Combination of docetaxel and cetuximab for penile cancer: A case report and literature review', Anti-Cancer Drugs, vol. 23, no. 5, pp. 573-577. https://doi.org/10.1097/CAD.0b013e328350ead7
Rescigno P, Matano E, Raimondo L, Mainolfi C, Federico P, Buonerba C et al. Combination of docetaxel and cetuximab for penile cancer: A case report and literature review. Anti-Cancer Drugs. 2012 Jun;23(5):573-577. https://doi.org/10.1097/CAD.0b013e328350ead7
Rescigno, Pasquale ; Matano, Elide ; Raimondo, Lucia ; Mainolfi, Ciro ; Federico, Piera ; Buonerba, Carlo ; Di Trolio, Rossella ; D'Aniello, Carmine ; Damiano, Vincenzo ; Palmieri, Giovannella ; De Placido, Sabino ; Di Lorenzo, Giuseppe. / Combination of docetaxel and cetuximab for penile cancer : A case report and literature review. In: Anti-Cancer Drugs. 2012 ; Vol. 23, No. 5. pp. 573-577.
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