Combination of docetaxel and cetuximab for penile cancer: A case report and literature review

Pasquale Rescigno; Elide Matano; Lucia Raimondo; Ciro Mainolfi; Piera Federico; Carlo Buonerba; Rossella Di Trolio; Carmine D'Aniello; Vincenzo Damiano; Giovannella Palmieri; Sabino De Placido; Giuseppe Di Lorenzo

doi:10.1097/CAD.0b013e328350ead7

Combination of docetaxel and cetuximab for penile cancer: A case report and literature review

Pasquale Rescigno, Elide Matano, Lucia Raimondo, Ciro Mainolfi, Piera Federico, Carlo Buonerba, Rossella Di Trolio, Carmine D'Aniello, Vincenzo Damiano, Giovannella Palmieri, Sabino De Placido, Giuseppe Di Lorenzo

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Contribution to journal › Article › peer-review

Abstract

Guidelines on the treatment of metastatic squamous cell carcinoma of the penis are limited to a few prospective trials. Cisplatin-based regimens represent the standard of treatment with promising activity of taxanes. Recently, epidermal growth factor receptor overexpression has been shown in these patients. We treated an elderly man with a docetaxel-cetuximab combination after failure of the cisplatin regimen. We observed a necrosis of the inguinal lymph nodes and a reduction of F-fluorodeoxyglucose uptake at PET/CT scan. Only mild mucositis and skin toxicity had been detected. Our case report, the first in the literature, shows that this combination is active and well tolerated in penile squamous cell carcinoma.

Original language	English
Pages (from-to)	573-577
Number of pages	5
Journal	Anti-Cancer Drugs
Volume	23
Issue number	5
DOIs	https://doi.org/10.1097/CAD.0b013e328350ead7
Publication status	Published - Jun 2012

Keywords

cetuximab
chemotherapy
metastatic penile cancer

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Cancer Research
Oncology

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title = "Combination of docetaxel and cetuximab for penile cancer: A case report and literature review",

abstract = "Guidelines on the treatment of metastatic squamous cell carcinoma of the penis are limited to a few prospective trials. Cisplatin-based regimens represent the standard of treatment with promising activity of taxanes. Recently, epidermal growth factor receptor overexpression has been shown in these patients. We treated an elderly man with a docetaxel-cetuximab combination after failure of the cisplatin regimen. We observed a necrosis of the inguinal lymph nodes and a reduction of F-fluorodeoxyglucose uptake at PET/CT scan. Only mild mucositis and skin toxicity had been detected. Our case report, the first in the literature, shows that this combination is active and well tolerated in penile squamous cell carcinoma.",

keywords = "cetuximab, chemotherapy, metastatic penile cancer",

author = "Pasquale Rescigno and Elide Matano and Lucia Raimondo and Ciro Mainolfi and Piera Federico and Carlo Buonerba and {Di Trolio}, Rossella and Carmine D'Aniello and Vincenzo Damiano and Giovannella Palmieri and {De Placido}, Sabino and {Di Lorenzo}, Giuseppe",

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doi = "10.1097/CAD.0b013e328350ead7",

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T2 - A case report and literature review

AU - Rescigno, Pasquale

AU - Matano, Elide

AU - Raimondo, Lucia

AU - Mainolfi, Ciro

AU - Federico, Piera

AU - Buonerba, Carlo

AU - Di Trolio, Rossella

AU - D'Aniello, Carmine

AU - Damiano, Vincenzo

AU - Palmieri, Giovannella

AU - De Placido, Sabino

AU - Di Lorenzo, Giuseppe

PY - 2012/6

Y1 - 2012/6

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AB - Guidelines on the treatment of metastatic squamous cell carcinoma of the penis are limited to a few prospective trials. Cisplatin-based regimens represent the standard of treatment with promising activity of taxanes. Recently, epidermal growth factor receptor overexpression has been shown in these patients. We treated an elderly man with a docetaxel-cetuximab combination after failure of the cisplatin regimen. We observed a necrosis of the inguinal lymph nodes and a reduction of F-fluorodeoxyglucose uptake at PET/CT scan. Only mild mucositis and skin toxicity had been detected. Our case report, the first in the literature, shows that this combination is active and well tolerated in penile squamous cell carcinoma.

KW - cetuximab

KW - chemotherapy

KW - metastatic penile cancer

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Combination of docetaxel and cetuximab for penile cancer: A case report and literature review

Abstract

Keywords

ASJC Scopus subject areas

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